hsd17b10

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hsd17b10

Official Full Name hydroxysteroid (17-beta) dehydrogenase 10
Background Mutations in several genes associated with early onset Alzheimer’s result in increased extracellular concentrations of the longer form of the beta-amyloid peptide Ab 1-42 relative to Ab 1-40. It is this longer form of Ab that has been shown to be toxic to neurons and may serve as a catalyst for the aggregation and deposition of Ab to produce the neurotoxic effects associated with senile plaque formation. Using the Ab peptide in a yeast two-hybrid screen, a novel interacting protein designated the endoplasmic reticulum-associated amyloid beta-peptide-binding protein (ERAB)/L-3-hydroxyacyl-CoA dehydrogenase type II has been identified. It is shown to be expressed at high levels in Alzheimer’s disease-affected brain. ERAB may contribute to neuronal dysfunction in Alzheimer’s disease.
Synonyms HSD17B10; hydroxysteroid (17-beta) dehydrogenase 10; HADH2, hydroxyacyl Coenzyme A dehydrogenase, type II, hydroxyacyl Coenzyme A dehydrogenase, type II , mental retardation, X linked, syndromic 10 , MRXS10; 3-hydroxyacyl-CoA dehydrogenase type-2; 17b HSD10; AB binding alcohol dehydrogenase; ABAD; CAMR; ERAB; MHBD; MRPP2; SDR5C1; short chain dehydrogenase/reductase family 5C; member 1; type 10 17b HSD; type 10 17beta hydroxysteroid dehydrogenase; AB-binding alcohol dehydrogenase; mitochondrial ribonuclease P protein 2; 3-hydroxy-2-methylbutyryl-CoA dehydrogenase; short chain type dehydrogenase/reductase XH98G2; amyloid-beta peptide binding alcohol dehydrogenase; short chain L-3-hydroxyacyl-CoA dehydrogenase type 2; short chain dehydrogenase/reductase family 5C, member 1; endoplasmic reticulum-associated amyloid beta-peptide-binding protein; HCD2; HADH2; MRX17; MRX31; SCHAD; MRXS10; 17b-HSD10; DUPXp11.22
    • Species :
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • GST
    • His
    • T7
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HSD17B10-1707H Recombinant Human Hydroxysteroid Dehydrogenase 10, His-tagged Human His
    Human HSD17B10-28684TH Recombinant Human HSD17B10, His-tagged E.coli His
    Human HSD17B10-28686TH Recombinant Human HSD17B10 N/A
    Human HSD17B10-4780H Recombinant Human HSD17B10 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human HSD17B10-4781H Recombinant Human HSD17B10 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human HSD17B10-5064H Recombinant Human HSD17B10 Protein, GST-tagged Wheat Germ GST
    Human HSD17B10-5376HCL Recombinant Human HSD17B10 293 Cell Lysate HEK293 N/A
    Human HSD17B10-7002H Recombinant Human HSD17B10, GST-tagged Sf9 Insect Cell GST
    Mouse Hsd17b10-1093M Recombinant Mouse Hsd17b10 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse Hsd17b10-1408M Recombinant Mouse Hsd17b10 protein, His & T7-tagged E.coli His/T7
    Rat HSD17B10-2273R Recombinant Rat HSD17B10 Protein (2-261 aa), His-tagged Yeast His
    Cynomolgus Monkey HSD17B10-597C Recombinant Cynomolgus HSD17B10 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque HSD17B10-2153R Recombinant Rhesus monkey HSD17B10 Protein, His-tagged Mammalian Cell His
    Zebrafish HSD17B10-1604Z Recombinant Zebrafish HSD17B10 Mammalian Cell His

    hsd17b10 involved in several pathways and played different roles in them. We selected most pathways hsd17b10 participated on our site, such as Valine, leucine and isoleucine degradation, Metabolic pathways, Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with hsd17b10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Valine, leucine and isoleucine degradation ALDH3A2A; ACSF3; DLDH; ALDH9A1B; AUH; ALDH7A1; ACAD8; ALDH2; MCCC2; BCKDHB
    Metabolic pathways PGM2; FUT9A; COX4I1; AKR1A1A; NAT; PIP5K1BB; BPGM; UQCRC2A; OLAH; GUK1B
    Alzheimers disease Casp3; ITPR2; NDUFV3; CHP; COX8A; NDUFB8; NDUFS4; NDUFC1; CAPN2; NDUFB5

    hsd17b10 has several biochemical functions, for example, 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity, 3-hydroxyacyl-CoA dehydrogenase activity, NAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by hsd17b10 itself. We selected most functions hsd17b10 had, and list some proteins which have the same functions with hsd17b10. You can find most of the proteins on our site.

    Function Related Protein
    3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity HSD17B10
    3-hydroxyacyl-CoA dehydrogenase activity HADHA; HSD17B10; HSD17B4; HSD17B8; EHHADH; HADHAA; HADHAB; HADH; HADHB; H2-KE6
    NAD binding PHGDH; HSD3B4; CTBP2A; HSD17B10; HIBADHA; GRHPRB; IDH3A; CTBP2L; GRHPRA; NDUFS2
    acetoacetyl-CoA reductase activity HSD17B10
    beta-amyloid binding COL25A1; MAPK8IP2; ACHE; CLSTN1; ITM2C; BCHE; Apba1; APBB3; CD74; NGFR
    cholate 7-alpha-dehydrogenase activity HSD17B10
    estradiol 17-beta-dehydrogenase activity HSD17B10; HSD17B12B; HSD17B1; HSD17B12A; HSD17B2; HSD17B11; HSD17B12; AKR1B15; AKR1C6; HSD17B7
    estrogen receptor binding FUS; PCNA; TMEM38A; CNOT1; STRN; PADI2; PPARG; PPID; DDX5; PHB2
    identical protein binding CBS; STK10; HAND1; MICU1; GRASP; CALHM1; PTEN; WAS; SLC2A1; SERPINB1A
    poly(A) RNA binding PRPF31; S100A4; NARG1; UBAP2L; MRPL39; MSI1; H1FX; C11orf68; SEC61B; EIF2C3
    protein binding TPX2; STATH; HILPDA; HIST1H3F; DOT1L; PYGB; HSP90AA1; ASL; ARAP3; STAT2
    steroid binding CYP21A1; PAQR7; PGR; CYP3A4; PAQR5B; PGRMC2; CYP21A2; UGT1A1; PGRMC1; SERPINA6
    testosterone dehydrogenase [NAD(P)] activity HSD17B10

    hsd17b10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with hsd17b10 here. Most of them are supplied by our site. Hope this information will be useful for your research of hsd17b10.

    APP; TRMT10C; mt-trna_tyr_rna; KIAA0391; HTRA2; UBE2D1; CHD3; q7cie3_yerpe; FAF1; Srp72; NOP56; GABARAP

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