IBSP
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Official Full Name
integrin-binding sialoprotein
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Overview
The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. -
Synonyms
integrin-binding sialoprotein; Cell-binding sialoprotein; BSP; BNSP; BSP-II; BSP II; SP-II; bone sialoprotein 2; Bone sialoprotein II; OTTHUMP00000161175; IBSP;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- CHO
- E.coli
- HEK293
- HEK293F
- Human Cell
- Insect Cell
- Mammalian Cell
- His
- Fc
- Avi
- Flag
- SUMO
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
IBSP involved in several pathways and played different roles in them. We selected most pathways IBSP participated on our site, such as PIK-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with IBSP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| PIK-Akt signaling pathway | RPS6KB1;LPAR2;EIF4E1B;IKBKG;ITGAV;YWHAB;PPP2R3A;PIK3CG;IL7 |
| Focal adhesion | BIRC2;SHC1;ITGA6B;ITGA8;PIK3R3B;LAMA1;ERBB2;ROCK1;SRMS |
| ECM-receptor interaction | COL2A1B;COL5A2A;Npnt;ITGB5;COL4A3;Itga10&Itgb1;ITGAV;COL6A5;COL4A6 |
IBSP has several biochemical functions, for example, molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by IBSP itself. We selected most functions IBSP had, and list some proteins which have the same functions with IBSP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| molecular_function | TPM3;GDPD4;LPGAT1;STRA6L;Actl10;OGFRL1;KIAA1217;SPATA3;C1orf116 |
IBSP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IBSP here. Most of them are supplied by our site. Hope this information will be useful for your research of IBSP.
- Reviews
- Q&As
Customer Reviews (3)
Write a reviewIn addition to its impeccable quality, the manufacturer of the IBSP protein provides outstanding technical support that can efficiently resolve any challenges encountered during my experiments.
Such attentive support significantly minimizes potential setbacks and facilitates a seamless and efficient experimental process.
The manufacturer's dedicated and knowledgeable support team is readily available to address any concerns, provide guidance, and offer timely solutions.
Q&As (5)
Ask a questionYes, mutations in the IBSP gene have been linked to certain inherited bone diseases, highlighting the genetic basis of IBSP protein-related pathologies.
IBSP protein is implicated in bone healing and regeneration, making it relevant in orthopedic surgeries for the treatment of fractures and bone defects.
Yes, elevated or reduced levels of IBSP protein can serve as prognostic indicators for conditions such as osteoporosis and bone metastasis.
IBSP protein is involved in the mineralization of dental tissues and can serve as a biomarker for dental diseases such as periodontitis and dental caries.
IBSP protein is a potential target for the development of novel therapies for bone disorders, as modulating its expression or activity can influence bone formation and remodeling.
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