Active Recombinant Human IBSP, His-tagged
Cat.No. : | IBSP-261H |
Product Overview : | Recombinant Human IBSP (Accession # AAC95490) Phe17-Gln317, fused with a C-terminal 10-His tag, was produced in Chinese Hamster Ovary cell line, CHO-derived. |
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Source : | CHO cells |
Species : | Human |
Tag : | His |
Predicted N Terminal : | Phe17 |
Form : | Lyophilized from a 0.2 µm filtered solution in MES and NaCl. |
Bio-activity : | Measured by the ability of the immobilized protein to support the adhesion of the MCF-7 human breast cancer cells.When 5 x10 4 cells/well are added to recombinant human IBSP-coated plates (3 µg/mL with 100 µL/well), approximately 60 - 80% will adhere after 30 minutes at 37° C.Optimal concentration depends on cell type as well as the application or research objectives. |
Molecular Mass : | Recombinant Human IBSP, His-tagged has a calculated MW of 34.7 kDa. In SDS-PAGE migrates as 75-90 kDa, reducing conditions. |
Purity : | >90%, by SDS-PAGE under reducing conditions and visualized by silver stain. |
Storage : | Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC). |
Protein length : | Phe17-Gln317 |
Gene Name : | IBSP integrin-binding sialoprotein [ Homo sapiens ] |
Official Symbol : | IBSP |
Synonyms : | IBSP; integrin-binding sialoprotein; bone sialoprotein 2; bone sialoprotein; bone sialoprotein II; BSP; BSP II; SP II; cell-binding sialoprotein; BNSP; SP-II; BSP-II; |
Gene ID : | 3381 |
mRNA Refseq : | NM_004967 |
Protein Refseq : | NP_004958 |
MIM : | 147563 |
UniProt ID : | P21815 |
Chromosome Location : | 4q21.1 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewIn addition to its impeccable quality, the manufacturer of the IBSP protein provides outstanding technical support that can efficiently resolve any challenges encountered during my experiments.
Such attentive support significantly minimizes potential setbacks and facilitates a seamless and efficient experimental process.
The manufacturer's dedicated and knowledgeable support team is readily available to address any concerns, provide guidance, and offer timely solutions.
Q&As (5)
Ask a questionYes, mutations in the IBSP gene have been linked to certain inherited bone diseases, highlighting the genetic basis of IBSP protein-related pathologies.
IBSP protein is implicated in bone healing and regeneration, making it relevant in orthopedic surgeries for the treatment of fractures and bone defects.
Yes, elevated or reduced levels of IBSP protein can serve as prognostic indicators for conditions such as osteoporosis and bone metastasis.
IBSP protein is involved in the mineralization of dental tissues and can serve as a biomarker for dental diseases such as periodontitis and dental caries.
IBSP protein is a potential target for the development of novel therapies for bone disorders, as modulating its expression or activity can influence bone formation and remodeling.
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