Active Recombinant Human IBSP, His-tagged

Cat.No. : IBSP-261H
Product Overview : Recombinant Human IBSP (Accession # AAC95490) Phe17-Gln317, fused with a C-terminal 10-His tag, was produced in Chinese Hamster Ovary cell line, CHO-derived.
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Source : CHO cells
Species : Human
Tag : His
Predicted N Terminal : Phe17
Form : Lyophilized from a 0.2 µm filtered solution in MES and NaCl.
Bio-activity : Measured by the ability of the immobilized protein to support the adhesion of the MCF-7 human breast cancer cells.When 5 x10 4 cells/well are added to recombinant human IBSP-coated plates (3 µg/mL with 100 µL/well), approximately 60 - 80% will adhere after 30 minutes at 37° C.Optimal concentration depends on cell type as well as the application or research objectives.
Molecular Mass : Recombinant Human IBSP, His-tagged has a calculated MW of 34.7 kDa. In SDS-PAGE migrates as 75-90 kDa, reducing conditions.
Purity : >90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Storage : Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC).
Protein length : Phe17-Gln317
Gene Name : IBSP integrin-binding sialoprotein [ Homo sapiens ]
Official Symbol : IBSP
Synonyms : IBSP; integrin-binding sialoprotein; bone sialoprotein 2; bone sialoprotein; bone sialoprotein II; BSP; BSP II; SP II; cell-binding sialoprotein; BNSP; SP-II; BSP-II;
Gene ID : 3381
mRNA Refseq : NM_004967
Protein Refseq : NP_004958
MIM : 147563
UniProt ID : P21815
Chromosome Location : 4q21.1

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Customer Reviews (3)

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Reviews
01/27/2023

    In addition to its impeccable quality, the manufacturer of the IBSP protein provides outstanding technical support that can efficiently resolve any challenges encountered during my experiments.

    03/01/2020

      Such attentive support significantly minimizes potential setbacks and facilitates a seamless and efficient experimental process.

      10/03/2016

        The manufacturer's dedicated and knowledgeable support team is readily available to address any concerns, provide guidance, and offer timely solutions.

        Q&As (5)

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        Are there any genetic variations in the IBSP gene associated with bone disorders? 06/10/2022

        Yes, mutations in the IBSP gene have been linked to certain inherited bone diseases, highlighting the genetic basis of IBSP protein-related pathologies.

        How is IBSP protein related to orthopedic surgery? 05/01/2022

        IBSP protein is implicated in bone healing and regeneration, making it relevant in orthopedic surgeries for the treatment of fractures and bone defects.

        Can IBSP protein be used as a prognostic marker for bone-related diseases? 04/25/2022

        Yes, elevated or reduced levels of IBSP protein can serve as prognostic indicators for conditions such as osteoporosis and bone metastasis.

        What role does IBSP protein play in dental medicine? 02/08/2018

        IBSP protein is involved in the mineralization of dental tissues and can serve as a biomarker for dental diseases such as periodontitis and dental caries.

        How is IBSP protein utilized in the development of therapeutic interventions? 05/25/2017

        IBSP protein is a potential target for the development of novel therapies for bone disorders, as modulating its expression or activity can influence bone formation and remodeling.

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