Active Recombinant Human Integrin-binding Sialoprotein, His-tagged
Cat.No. : | IBSP-2711H |
Product Overview : | Recombinant Human Bone Sialoprotein (Phe17Gln317) fused a His-tag at C-terminal was expressed in CHO cells. |
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Cat. No. : | IBSP-2711H |
Description : | Bone sialoprotein (BSP) is a component of mineralized tissues such as bone, dentin, cementum and calcified cartilage. BSP is a significant component of the bone extracellular matrix and has been suggested to constitute approximately 8% of all non-collagenous proteins found in bone and cementum. |
Source : | CHO Cells |
Species : | Human |
Predicted NTerminal : | Phe17 |
SDS-PAGE : | 7590 kDa, reducing conditions |
Activity : | Measured by the ability of the immobilized protein to support the adhesion of the MCF-7human breast cancer cells. When 5 x104 cells/well are added to recombinant human IBSP- coated plates (3 µg/mL with 100 µL/well), approximately 60-80% will l adhereafter 30 minutes at 37°C. |
Endotoxin : | Less than 1.0 EU per 1 μg of the protein by the LAL method. |
Purity : | >90%, by SDSPAGE under reducing conditions and visualized by silver stain. |
Formulation : | Lyophilized from a 0.2 μm filtered solution in MES and NaCl. See Certificate of Analysis for details. |
Reconstitution : | Reconstitute at 100 μg/mL in sterile PBS. |
Storage : | 12 months from date of receipt, -20 to -70°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to -70°C under sterile conditions after reconstitution. Avoid repeated freeze¬thaw cycles. |
Gene Name : | IBSP integrin-binding sialoprotein [ Homo sapiens ] |
Official Symbol : | IBSP |
Synonyms : | integrin-binding sialoprotein; BSP; BNSP; SP-II; BSP-II; IBSP; bone sialoprotein 2; BSP II; bone sialoprotein II; cell-binding sialoprotein; Cell-binding sialoprotein; Bone sialoprotein II |
Gene ID : | 3381 |
mRNA Refseq : | NM_004967 |
Protein Refseq : | NP_004958 |
MIM : | 147563 |
UniProt ID : | P21815 |
Chromosome Location : | 4q21-q25 |
Pathway : | ECM-receptor interaction; Focal adhesion; Integrin cell surface interactions |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewIn addition to its impeccable quality, the manufacturer of the IBSP protein provides outstanding technical support that can efficiently resolve any challenges encountered during my experiments.
Such attentive support significantly minimizes potential setbacks and facilitates a seamless and efficient experimental process.
The manufacturer's dedicated and knowledgeable support team is readily available to address any concerns, provide guidance, and offer timely solutions.
Q&As (5)
Ask a questionYes, mutations in the IBSP gene have been linked to certain inherited bone diseases, highlighting the genetic basis of IBSP protein-related pathologies.
IBSP protein is implicated in bone healing and regeneration, making it relevant in orthopedic surgeries for the treatment of fractures and bone defects.
Yes, elevated or reduced levels of IBSP protein can serve as prognostic indicators for conditions such as osteoporosis and bone metastasis.
IBSP protein is involved in the mineralization of dental tissues and can serve as a biomarker for dental diseases such as periodontitis and dental caries.
IBSP protein is a potential target for the development of novel therapies for bone disorders, as modulating its expression or activity can influence bone formation and remodeling.
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