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Official Full Name IGFBP3 insulin-like growth factor binding protein 3
Background This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an;IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor;acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the;plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate;transcriptional splice variants, encoding different isoforms, have been characterized.
Synonyms IGFBP3; insulin-like growth factor binding protein 3; insulin-like growth factor-binding protein 3; acid stable subunit of the 140 K IGF complex; binding protein 29; binding protein 53; BP 53; growth hormone dependent binding protein; IBP3; IGF binding protein 3; IBP-3; IGFBP-3; IGF-binding protein 3; growth hormone-dependent binding protein; BP-53
    • Species :
    • Cattle
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Pig
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Human Cell
    • Mammalian Cell
    • NS0
    • NSO
    • Rabbit
    • Tag :
    • GST
    • His
    • T7
    • Met
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CAB11559RH Rabbit Anti-Human IGFBP3 Monoclonal Antibody Rabbit N/A
    Human IGFBP3-14107H Recombinant Human IGFBP3, GST-tagged E.coli GST
    Human IGFBP3-145H Recombinant Human Insulin-like Growth Factor Binding Protein 3 HEK293 N/A
    Human IGFBP3-197H Insulin-like growth Factor Binding Protein-3 Reference standard E.coli N/A
    Human IGFBP3-26377TH Recombinant Human IGFBP3 N/A
    Human IGFBP3-2716H Recombinant Human IGFBP3 protein, His-tagged HEK293 His
    Human IGFBP3-28257TH Recombinant Human IGFBP3 E.coli N/A
    Human IGFBP3-2927HCL Recombinant Human IGFBP3 cell lysate Human Cell N/A
    Human IGFBP3-489H Recombinant Human IGFBP3, Met-tagged NS0 Met
    Human IGFBP3-758H Recombinant Human IGFBP3, His tagged Human Cell His
    Human IGFBP3-80H Recombinant Human IGFBP3 protein E.coli N/A
    Human IGFBP3-828H Recombinant Human IGFBP3 protein, His-tagged E.coli His
    Mouse Igfbp3-1750M Recombinant Mouse Insulin-like Growth Factor Binding Protein 3 NSO N/A
    Mouse Igfbp3-7M Recombinant Mouse IGFBP3, carrier free NSO N/A
    Mouse Igfbp3-829M Recombinant Mouse Igfbp3 protein, His-tagged E.coli His
    Rat Igfbp3-831R Recombinant Rat Igfbp3 protein, His-tagged E.coli His
    Cynomolgus Monkey IGFBP3-1230CCL Recombinant Cynomolgus IGFBP3 cell lysate Human Cell N/A
    Cynomolgus Monkey IGFBP3-8820C Recombinant Cynomolgus IGFBP3, His tagged Human Cell His
    Rhesus Macaque IGFBP3-2218R Recombinant Rhesus monkey IGFBP3 Protein, His-tagged Mammalian Cell His
    Chicken IGFBP3-3732C Recombinant Chicken IGFBP3 Mammalian Cell His
    Zebrafish IGFBP3-11766Z Recombinant Zebrafish IGFBP3 Mammalian Cell His
    Cattle IGFBP3-827C Recombinant Cattle IGFBP3 protein, His & T7-tagged E.coli His/T7
    Pig IGFBP3-830P Recombinant Pig IGFBP3 protein, His & T7-tagged E.coli His/T7

    igfbp3 involved in several pathways and played different roles in them. We selected most pathways igfbp3 participated on our site, such as p signaling pathway, Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with igfbp3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    p signaling pathway GADD45BB; CYCSB; PIDD1; CCNB2; GADD45AB; SERPINB5; TP73; SHISA5; SFN; Casp3
    Transcriptional misregulation in cancer FCGR1A; FLI1; DEFA3; HOXA10; Bcl2a1b; MAX; FLT1; CD40; SMAD1; CCND2

    igfbp3 has several biochemical functions, for example, fibronectin binding, insulin-like growth factor I binding, insulin-like growth factor II binding. Some of the functions are cooperated with other proteins, some of the functions could acted by igfbp3 itself. We selected most functions igfbp3 had, and list some proteins which have the same functions with igfbp3. You can find most of the proteins on our site.

    Function Related Protein
    fibronectin binding IGFBP3; CTGF; CTSK; ITGB1A; IGFBP5A; ITGB3; THBS1; MFAP2; ITGB1; FBLN1
    insulin-like growth factor I binding IGFBP4; IGF1R; IGFBP3; IGFBP5B; INSR; IGFBP6B; IGFBP5A; IGFBP2; IGFBP2B; IGFBP2A
    insulin-like growth factor II binding IGFBP1A; IGFBP5A; IGFBP2B; IGFBP1B; IGFBP5; IGFBP6A; IGFBP6B; IGFBP6; INSR; IGFBP2
    insulin-like growth factor binding HTRA3A; IGFBP6B; IGF1RA; NOV; IGFBP5A; CYR61; CTGF; DEFB126; KAZALD2; IGFBP7
    metal ion binding TCN2; PRLR; SOD3A; MYO9B; ZNF695; ARHGAP29B; ZFP36L1; GPHN; PRKCBB; ASXL3
    protein binding PLN; SGIP1; MINK1; DKK1; ZFP335; CHN1; ZMYM4; IRF5; BTG1; TTK
    protein tyrosine phosphatase activator activity IGFBP3; PPP2R4

    igfbp3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with igfbp3 here. Most of them are supplied by our site. Hope this information will be useful for your research of igfbp3.

    EGFR; PRKDC; AURKA; BUB1; KRAS; CCND1; BMPR1A; GTF3C1; POLA2; STK11; q8czf9_yerpe; dinB; FBXW7; MLH3; RAD54B

    Lariviere, N; Law, J; et al. Dissection of a Novel Autocrine Signaling Pathway via Quantitative Secretome and Interactome Mapping. JOURNAL OF PROTEOME RESEARCH 13:3432-3443(2014).
    Moody, G; Beltran, PJ; et al. IGF1R blockade with ganitumab results in systemic effects on the GH-IGF axis in mice. JOURNAL OF ENDOCRINOLOGY 221:145-155(2014).

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