IGFBP3
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Official Full Name
IGFBP3 insulin-like growth factor binding protein 3
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Overview
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an;IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor;acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the;plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate;transcriptional splice variants, encoding different isoforms, have been characterized. -
Synonyms
IGFBP3; insulin-like growth factor binding protein 3; insulin-like growth factor-binding protein 3; acid stable subunit of the 140 K IGF complex; binding protein 29; binding protein 53; BP 53; growth hormone dependent binding protein; IBP3; IGF binding protein 3; IBP-3; IGFBP-3; IGF-binding protein 3; growth hormone-dependent binding protein; BP-53;
- Recombinant Proteins
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- GST
- His
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- TRxA
- N
- SUMO
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
IGFBP3 involved in several pathways and played different roles in them. We selected most pathways IGFBP3 participated on our site, such as p signaling pathway, Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with IGFBP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| p signaling pathway | PTENB;COP1;BAX;CD82B;PMAIP1;FAS;GADD45BA;PTENA;CDK1 |
| Transcriptional misregulation in cancer | EWSR1;CCNT1;DOT1L;Pdgfa&Pdgfb;H3F3A;MYCN;FCGR1A;HOXA9;SIN3A |
IGFBP3 has several biochemical functions, for example, fibronectin binding, insulin-like growth factor I binding, insulin-like growth factor II binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IGFBP3 itself. We selected most functions IGFBP3 had, and list some proteins which have the same functions with IGFBP3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| fibronectin binding | ITGB3;IGFBP3;ITGA3;SFRP2;PLEKHA2;MMP13;FSTL3;ITGA4;ITGB1A |
| insulin-like growth factor I binding | IGFBP5B;IGFBP2B;INSR;IGFBP5A;IGFBP5;IGFBP6A;IGFBP6B;IGFBP3;IGFBP1A |
| insulin-like growth factor II binding | IGFBP6B;IGFBP5;IGFBP1B;IGFBP2B;IGFBP4;INSR;IGFBP5A;IGFBP3;IGFBP6 |
| insulin-like growth factor binding | WISP1;CTGF;ESM1;WISP1A;IGFBP5B;WISP2;WISP3;IGFBP1A;HTRA1A |
| metal ion binding | DPH3;CYP27C1;KLF7B;LRP2;AOX4;ACY3.1;TET3;GMPR;RACGAP1 |
| protein binding | ETV7;LSAMP;TBC1D20;RIC8A;NTRK1;RSPH1;C1GALT1C1;THAP11;TCOF1 |
| protein tyrosine phosphatase activator activity | IGFBP3;PPP2R4 |
IGFBP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IGFBP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of IGFBP3.
EGFR; PRKDC; AURKA; BUB1; KRAS; CCND1; BMPR1A; GTF3C1; POLA2; STK11; q8czf9_yerpe; dinB; FBXW7; MLH3; RAD54B
Research Area
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Customer Reviews (3)
Write a reviewA manufacturer that offers customization options can enable the researcher to adhere to their experimental design requirements more effectively.
A reliable manufacturer should be able to provide a consistently pure and high-quality IGFBP3 protein, ensuring that the samples are suitable for research purposes.
This can help ensure compatibility between different components used in the trials and ease the overall experimental workflow.
Q&As (5)
Ask a questionYes, genetic variations can affect IGFBP3 expression, potentially leading to differences in protein levels among individuals.
IGFBP3 is involved in bone metabolism and is associated with bone mineral density. Low levels of IGFBP3 have been linked to decreased bone density and increased risk of fractures.
The potential side effects of therapies targeting IGFBP3 are still being studied, and it varies depending on the specific treatment approach being used.
Healthy lifestyle choices, including a balanced diet and regular exercise, can positively influence IGFBP3 levels, promoting overall health and reducing the risk of related diseases.
IGFBP3 deficiency can impact children's growth and development, potentially leading to short stature and delayed puberty, as IGFBP3 is a key regulator of growth hormone actions.
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