Recombinant Human IGFBP3 Protein (28-291aa), N-His-tagged

• Cat.No.: IGFBP3-12H
• Product Overview: Recombinant human IGFBP3 (28-291aa), fused to His-tag at N-terminus, was expressed in E. coli.

Specification

• Description: This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
• Source: E. coli
• Species: Human
• Tag: N-His
• Form: Liquid
• Molecular Mass: 31 kDa (285aa)
• Protein Length: 28-291aa
• AA Sequence: MGSSHHHHHHSSGLVPRGSHMGASS AGLGPVVRCEPCDARALAQCAPPPA VCAELVREPGCGCCLTCALSEGQPC GIYTERCGSGLRCQPSPDEARPLQA LLDGRGLCVNASAVSRLRAYLLPAP PAPGNASESEEDRSAGSVESPSVSS THRVSDPKFHPLHSKIIIIKKGHAK DSQRYKVDYESQSTDTQNFSSESKR ETEYGPCRREMEDTLNHLKFLNVLS PRGVHIPNCDKKGFYKKKQCRPSKG RKRGFCWCVDKYGQPLPGYTTKGKE DVHCYSMQSK
• Purity: > 90% by SDS-PAGE
• Applications: SDS-PAGE, Denatured
• Storage: Can be stored at +2 to +8 centigrade for 1 week. For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.
• Concentration: 1 mg/mL (determined by Bradford assay)
• Storage Buffer: 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol

Gene Information

• Gene Name: IGFBP3 insulin like growth factor binding protein 3 [ Homo sapiens (human) ]
• Official Symbol: IGFBP3
• Synonyms: IGFBP3; insulin like growth factor binding protein 3; IBP3; BP-53; insulin-like growth factor-binding protein 3; IBP-3; IGF-binding protein 3; IGFBP-3; acid stable subunit of the 140 K IGF complex; binding protein 29; binding protein 53; growth hormone-dependent binding protein
• Gene ID: 3486
• mRNA Refseq: NM_000598
• Protein Refseq: NP_000589
• MIM: 146732
• UniProt ID: P17936