IL18BP

  • Official Full Name

    interleukin 18 binding protein

  • Overview

    Interleukin 18 binding protein (IL-18 BP) is a secreted glycoprotein, which may function as a natural anti-inflammatory and immunosuppressive molecule neutralizing the effects of high IL18 levels during inflammation. It can prevent IL18 receptor binding and inhibits the production of IFN-gamma induced by IL18 in KG-1 cells. Aizawa et al (1999) have purified a mouse IL-18 binding protein and subsequently cloned the murine and human cDNA. Human and murine IL18BP share 60 % amino acid similarity.
  • Synonyms

    IL18Bpa; interleukin-18-binding protein; IL-18BP; tadekinig-alfa; MC51L-53L-54L homolog gene product; I18BP_HUMAN; IL18 BP; IL18 BPa; Interleukin 18 binding protein; Tadekinig alfa;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • CHO
  • E.coli
  • HEK293
  • Human Cell
  • Mammalian Cell
  • Mammalian cells
  • C
  • Fc
  • hFc
  • His
  • Avi
  • Fc Chimera
  • Fc|His
  • GST
  • His (Fc)
  • human|IgG1|Fc
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IL18BP-264H Active Recombinant Human IL18BP, Fc Chimera Mammalian cells Fc Chimera
Human IL18BP-342H Active Recombinant Human IL18BP protein, His-tagged HEK293 His Met1-Gly194
Human IL18BP-2327H Recombinant Human IL18BP protein(Met1-Gly192), hFc-tagged HEK293 C-hFc Met1-Gly192
Human IL18BP-14162H Recombinant Human IL18BP, GST-tagged E.coli GST 30-194a.a.
Human IL18BP-3165H Active Recombinant Human IL18BP protein, His-tagged HEK293 His Thr31-Gly194
Human IL18BP-7240H Recombinant Human IL18BP, His-tagged E.coli His 31-194aa
Human IL18BP-769H Recombinant Human IL18BP, Fc-His tagged Human Cell Fc/His
Human IL18BP-1656H Recombinant Human Interleukin 18 Binding Protein Mammalian cells N/A
Human IL18BP-162H Recombinant Human IL18BP protein, Fc-tagged HEK293 human/IgG1/Fc Thr31-Gly194
Human IL18BP-2918HCL Recombinant Human IL18BP cell lysate Human Cell N/A
Human IL18BP-135H Recombinant Human IL18BP Protein, Thr31-Gly194, C-His-Avi tagged, Biotinylated HEK293 C-His-Avi Thr31-Gly194
Human IL18BP-194H Recombinant Human IL18BP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human IL18BP-2683H Active Recombinant Human IL18BP protein, hFc&His-tagged HEK293 hFc&His Thr31-Gly194
Human IL18BP-75H Active Recombinant Human IL18BP Protein CHO
Human IL18BP-194H-B Recombinant Human IL18BP Protein Pre-coupled Magnetic Beads HEK293
Human IL18BP-252I Active Recombinant Human IL18BP Protein CHO
Human IL18BP-315H Recombinant Human IL18BP Protein, His-tagged HEK293 His 194
Human IL18BP-316H Recombinant Human IL18BP Protein, Fc-tagged HEK293 Fc 194
Human IL18BP-1615H Active Recombinant Human IL18BP protein, Fc-tagged HEK293 Fc Thr31-Gly194
Human IL18BP-2662H Recombinant Human IL18BP Protein (Thr31-Gly194), His tagged E.coli His Thr31-Gly194
Mouse IL18BP-767M Active Recombinant Mouse IL18BP, His tagged HEK293 His Met 1-Ala 193
Mouse Il18bp-265M Active Recombinant Mouse Il18bp, Fc Chimera Mammalian cells Fc Chimera
Mouse IL18bp-1762M Recombinant Mouse Interleukin 18 Binding Protein Mammalian cells N/A
Mouse Il18bp-8339M Recombinant Mouse Il18bp Mammalian cells N/A
Mouse IL18BP-2674MCL Recombinant Mouse IL18BP cell lysate Human Cell N/A
Mouse Il18bp-142M Recombinant Mouse Il18bp Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Il18bp-5690M Recombinant Mouse Il18bp Protein (Thr29-Ala193), C-Fc tagged Mammalian cells C-Fc Thr29-Ala193
Mouse Il18bp-1577M Recombinant Mouse Il18bp protein, His-tagged E.coli His Thr29~Ala193 (Accession # Q9Z0M9)
Mouse Il18bp-142M-B Recombinant Mouse Il18bp Protein Pre-coupled Magnetic Beads HEK293
Mouse Il18bp-5307M Recombinant Mouse Il18bp protein, His-tagged E.coli His 29-193aa
Rat Il18bp-1578R Recombinant Rat Il18bp protein, His-tagged E.coli His Thr29~Pro193 (Accession # Q9JLN2)
Cynomolgus IL18BP-57C Active Recombinant Cynomolgus IL18BP protein, His-tagged HEK293 His Thr28-Pro207
Cynomolgus IL18BP-57CB Active Recombinant Cynomolgus IL18BP protein, His-tagged, Biotinylated HEK293 His Thr28-Pro207
Cynomolgus Monkey IL18BP-56C Active Recombinant Cynomolgus Monkey IL18BP Protein, His-tagged CHO His 28-207
Rhesus Macaque IL18BP-2237R Recombinant Rhesus monkey IL18BP Protein, His-tagged Mammalian Cell His
Rhesus Macaque IL18BP-2058R-B Recombinant Rhesus Macaque IL18BP Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque IL18BP-2058R Recombinant Rhesus Macaque IL18BP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

IL18BP involved in several pathways and played different roles in them. We selected most pathways IL18BP participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with IL18BP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

IL18BP has several biochemical functions, for example, interleukin-18 binding, receptor antagonist activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL18BP itself. We selected most functions IL18BP had, and list some proteins which have the same functions with IL18BP. You can find most of the proteins on our site.

Function Related Protein
interleukin-18 binding
receptor antagonist activityIL18BP;ESR2;DKK1;LRPAP1;ADH7;AGTR2

IL18BP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL18BP here. Most of them are supplied by our site. Hope this information will be useful for your research of IL18BP.

pepP; q81jv7_bacan; groL

  • Q&As
  • Reviews

Q&As (10)

Ask a question
Can you elaborate on the experimental strategies used to assess the genetic polymorphisms and variations in IL18BP that might influence its function and disease susceptibility? 11/23/2021

Genetic association studies, sequencing analyses, and functional investigations explore how genetic variations in IL18BP might influence disease susceptibility and outcomes.

How are animal models and in vivo imaging techniques used to understand the role of IL18BP in modulating IL18-mediated immune responses in whole organisms? 10/17/2021

Knockout mice, transgenic models, and imaging techniques provide insights into IL18BP's impact on IL18-related immune responses in vivo.

What techniques are used to investigate the regulation of IL18BP expression by cytokines, growth factors, and other signaling molecules in different cell types? 09/06/2021

Promoter studies, siRNA knockdown, and cytokine stimulation assays investigate IL18BP regulation at the transcriptional and post-transcriptional levels.

How are cell-based assays and functional studies employed to dissect the mechanisms through which IL18BP modulates IL18-induced immune responses? 04/29/2021

Luciferase reporter assays, ELISAs, and functional cell assays probe how IL18BP modulates IL18-induced cytokine production and immune cell activation.

What experimental approaches are utilized to explore the potential allosteric effects of IL18BP on IL18 receptor complex formation and downstream signaling? 04/10/2021

Biophysical techniques, site-directed mutagenesis, and receptor binding assays reveal potential allosteric effects on IL18 signaling.

How do researchers experimentally characterize the binding affinity and kinetics between IL18BP and IL18, considering their critical role in regulating IL18-mediated inflammation? 09/07/2019

Surface plasmon resonance, isothermal titration calorimetry, and kinetic binding assays quantify IL18BP-IL18 interactions.

Can you explain the strategies used to assess the expression levels and tissue distribution of IL18BP in various physiological and pathological contexts? 03/08/2019

RT-qPCR, immunohistochemistry, and tissue microarray analyses determine the expression patterns of IL18BP in different tissues and diseases.

Could you elaborate on the methods used to investigate the structural determinants of IL18BP's interaction with IL18 and its impact on receptor binding? 12/12/2017

X-ray crystallography, NMR spectroscopy, and mutagenesis studies elucidate the structural basis of IL18BP-IL18 recognition.

How do researchers experimentally study the potential cross-talk between IL18BP and other cytokine regulatory systems, such as IL1Ra and soluble IL6 receptor? 09/24/2017

Cross-competition assays, co-stimulation studies, and receptor activation assays unveil potential interplay between IL18BP and other cytokine regulators.

What assays and methodologies are employed to evaluate the therapeutic potential of enhancing or inhibiting IL18BP activity in inflammatory diseases? 08/26/2017

Therapeutic antibody trials, in vitro functional screens, and disease model assessments evaluate IL18BP modulation as a potential anti-inflammatory strategy.

Customer Reviews (3)

Write a review
Reviews
06/03/2022

    Consistent binding affinity.

    03/01/2020

      High purity.

      05/04/2018

        Effective in neutralization assays.

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