IL18BP
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Official Full Name
interleukin 18 binding protein
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Background
Interleukin 18 binding protein (IL-18 BP) is a secreted glycoprotein, which may function as a natural anti-inflammatory and immunosuppressive molecule neutralizing the effects of high IL18 levels during inflammation. It can prevent IL18 receptor binding and inhibits the production of IFN-gamma induced by IL18 in KG-1 cells. Aizawa et al (1999) have purified a mouse IL-18 binding protein and subsequently cloned the murine and human cDNA. Human and murine IL18BP share 60 % amino acid similarity. -
Synonyms
IL18Bpa; interleukin-18-binding protein; IL-18BP; tadekinig-alfa; MC51L-53L-54L homolog gene product; I18BP_HUMAN; IL18 BP; IL18 BPa; Interleukin 18 binding protein; Tadekinig alfa;
- Involved Pathway
- Protein Function
- Interacting Protein
- IL18BP Related Gene Family
- IL18BP Related Research Area
IL18BP involved in several pathways and played different roles in them. We selected most pathways IL18BP participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with IL18BP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
IL18BP has several biochemical functions, for example, interleukin-18 binding, receptor antagonist activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL18BP itself. We selected most functions IL18BP had, and list some proteins which have the same functions with IL18BP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| interleukin-18 binding | |
| receptor antagonist activity | LRPAP1;AGTR2;ADH7;IL18BP;DKK1;ESR2 |
IL18BP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL18BP here. Most of them are supplied by our site. Hope this information will be useful for your research of IL18BP.
pepP; q81jv7_bacan; groL
- Q&As
- Reviews
Q&As (10)
Ask a questionGenetic association studies, sequencing analyses, and functional investigations explore how genetic variations in IL18BP might influence disease susceptibility and outcomes.
Knockout mice, transgenic models, and imaging techniques provide insights into IL18BP's impact on IL18-related immune responses in vivo.
Promoter studies, siRNA knockdown, and cytokine stimulation assays investigate IL18BP regulation at the transcriptional and post-transcriptional levels.
Luciferase reporter assays, ELISAs, and functional cell assays probe how IL18BP modulates IL18-induced cytokine production and immune cell activation.
Biophysical techniques, site-directed mutagenesis, and receptor binding assays reveal potential allosteric effects on IL18 signaling.
Surface plasmon resonance, isothermal titration calorimetry, and kinetic binding assays quantify IL18BP-IL18 interactions.
RT-qPCR, immunohistochemistry, and tissue microarray analyses determine the expression patterns of IL18BP in different tissues and diseases.
X-ray crystallography, NMR spectroscopy, and mutagenesis studies elucidate the structural basis of IL18BP-IL18 recognition.
Cross-competition assays, co-stimulation studies, and receptor activation assays unveil potential interplay between IL18BP and other cytokine regulators.
Therapeutic antibody trials, in vitro functional screens, and disease model assessments evaluate IL18BP modulation as a potential anti-inflammatory strategy.
Customer Reviews (3)
Write a reviewConsistent binding affinity. -
High purity. -
Effective in neutralization assays. -
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