Recombinant Human Interleukin 18 Binding Protein
- Gene Information
- Related Products
|Cat. No. :||IL18BP-1656H|
|Description :||IL-18-binding protein (IL-18BP) is a secreted glycoprotein that functions as a natural anti-inflammatory and immunosuppressive molecule neutralizing the effects of high IL18 levels during inflammation. There are four variants of IL-18BP and IL18BPa is the predominant form showing the highest affinity towards IL18. that IL-18 BPa:Fc has the potential to amplify anti-inflammatory actions of immunosuppressive drugs, and thus may prove to be a valuable novel pharmacological component in the treatment of human autoimmune diseases.|
|Molecular Weight :||The predicted molecular weight of Recombinant Human IL-18 BPa is Mr 44.2 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 65-75 kDa.|
|Source :||Mammalian cells|
|State Of Matter :||Lyophilized.|
|Purity :||>95% by SDS Page and analyzed by silver stain.|
|Endotoxin :||<1.0 EU/µg as determined by the LAL method.|
|Storage And Stability :||This lyophilized protein is stable for six to twelve months when stored desiccated at -20℃ to -70℃. After aseptic reconstitution, this protein may be stored at 2℃ to 8℃ for one month or at -20℃ to -70℃ in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.|
|Gene Name :||IL18BP interleukin 18 binding protein [Homo sapiens ]|
|Synonyms :||IL18BP; interleukin 18 binding protein; tadekinig-alfa; IL18BPa; OTTHUMP00000179143; MC51L-53L-54L homolog gene product; IL-18BP; OTTHUMP00000179141; Tadekinig-alfa;Interleukin-18-binding protein|
|Gene ID :||10068|
|mRNA Refseq :||NM_001039659|
|Protein Refseq :||NP_001034748|
|UniProt ID :||O95998|
|Chromosome Location :||11q13|
|Function :||interleukin-18 binding; receptor antagonist activity|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (10)Ask a question
Genetic association studies, sequencing analyses, and functional investigations explore how genetic variations in IL18BP might influence disease susceptibility and outcomes.
Knockout mice, transgenic models, and imaging techniques provide insights into IL18BP's impact on IL18-related immune responses in vivo.
Promoter studies, siRNA knockdown, and cytokine stimulation assays investigate IL18BP regulation at the transcriptional and post-transcriptional levels.
Luciferase reporter assays, ELISAs, and functional cell assays probe how IL18BP modulates IL18-induced cytokine production and immune cell activation.
Biophysical techniques, site-directed mutagenesis, and receptor binding assays reveal potential allosteric effects on IL18 signaling.
Surface plasmon resonance, isothermal titration calorimetry, and kinetic binding assays quantify IL18BP-IL18 interactions.
RT-qPCR, immunohistochemistry, and tissue microarray analyses determine the expression patterns of IL18BP in different tissues and diseases.
X-ray crystallography, NMR spectroscopy, and mutagenesis studies elucidate the structural basis of IL18BP-IL18 recognition.
Cross-competition assays, co-stimulation studies, and receptor activation assays unveil potential interplay between IL18BP and other cytokine regulators.
Therapeutic antibody trials, in vitro functional screens, and disease model assessments evaluate IL18BP modulation as a potential anti-inflammatory strategy.
Customer Reviews (3)Write a review
Consistent binding affinity. -
High purity. -
Effective in neutralization assays. -
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