Active Recombinant Cynomolgus IL18BP protein, His-tagged, Biotinylated

Cat.No. : IL18BP-57CB
Product Overview : Biotinylated Recombinant Cynomolgus IL18BP protein(A0A2K5UDJ4)(Thr28-Pro207) is expressed from HEK293 with His tag at the C-Terminus.
  • Specification
  • Gene Information
  • Related Products
Source : HEK293
Species : Cynomolgus
Tag : His
Form : Supplied as 0.22μm filtered solution in PBS (pH 7.4).
Bio-activity : Biotinylated Cynomolgus IL-18BP, His tag captured on CM5 Chip via anti-his antibody can bind Human IL-18, No Tag with an affinity constant of 1.67 nM as determined in SPR assay (Biacore T200).
Molecular Mass : The protein has a predicted MW of 21.14 kDa. Due to glycosylation, the protein migrates to 50-65 kDa based on Tris-Bis PAGE result.
Proteinlength : Thr28-Pro207
Endotoxin : Less than 1EU per μg by the LAL method.
Purity : > 95% as determined by Tris-Bis PAGE
> 90% as determined by HPLC
Storage : Valid for 12 months from date of receipt when stored at -80°C.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.
Gene Name : IL18BP interleukin 18 binding protein [ Homo sapiens ]
Official Symbol : IL18BP
Synonyms : IL18BP; interleukin 18 binding protein; interleukin-18-binding protein; IL18BPa; MC51L 53L 54L homolog gene product; IL-18BP; tadekinig-alfa; MC51L-53L-54L homolog gene product
Gene ID : 10068
mRNA Refseq : NM_001039659
Protein Refseq : NP_001034748
MIM : 604113
UniProt ID : O95998

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◆ Lysates
IL18BP-2674MCL Recombinant Mouse IL18BP cell lysate +Inquiry
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Related Gene

IL10 IL10RA IL10RB IL11 IL11RA Il11ra1 IL12 IL12A IL12B IL12RB1 IL13 IL13RA1 IL13RA2 IL15 IL15RA IL16 IL17A IL17B Il17c IL17D Il17f IL17RA IL17RD IL18 IL18BP IL18R1 IL18RAP Il19 Il1a IL1B IL1F10 IL1R1 Il1r2 IL1RAP IL1RAPL1 IL1RAPL2 IL1RL1 IL1RL2 Il1rn IL2 Il20 IL20RA IL21 IL21R IL22 IL22RA1 IL22RA2 IL23A IL24 Il25 IL27 IL27RA IL28A Il28b IL29 IL2RA IL2RB Il2rg IL3 IL31 IL32 Il33 Il34 IL3RA IL4 IL4R Il4ra Il5 IL5RA Il6 IL6R Il6ra IL6ST Il7 IL7R IL8 IL9 IL36A Il12rb2 IL17RB IL23R IL26 IL31RA IL36B IL36G IL36RN IL37 IL9R IL17RC IL17RE IL28RA IL4I1 IL20RB Il11ra2 IL7RA Il23a&Il12b

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

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Q&As (10)

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Can you elaborate on the experimental strategies used to assess the genetic polymorphisms and variations in IL18BP that might influence its function and disease susceptibility? 11/23/2021

Genetic association studies, sequencing analyses, and functional investigations explore how genetic variations in IL18BP might influence disease susceptibility and outcomes.

How are animal models and in vivo imaging techniques used to understand the role of IL18BP in modulating IL18-mediated immune responses in whole organisms? 10/17/2021

Knockout mice, transgenic models, and imaging techniques provide insights into IL18BP's impact on IL18-related immune responses in vivo.

What techniques are used to investigate the regulation of IL18BP expression by cytokines, growth factors, and other signaling molecules in different cell types? 09/06/2021

Promoter studies, siRNA knockdown, and cytokine stimulation assays investigate IL18BP regulation at the transcriptional and post-transcriptional levels.

How are cell-based assays and functional studies employed to dissect the mechanisms through which IL18BP modulates IL18-induced immune responses? 04/29/2021

Luciferase reporter assays, ELISAs, and functional cell assays probe how IL18BP modulates IL18-induced cytokine production and immune cell activation.

What experimental approaches are utilized to explore the potential allosteric effects of IL18BP on IL18 receptor complex formation and downstream signaling? 04/10/2021

Biophysical techniques, site-directed mutagenesis, and receptor binding assays reveal potential allosteric effects on IL18 signaling.

How do researchers experimentally characterize the binding affinity and kinetics between IL18BP and IL18, considering their critical role in regulating IL18-mediated inflammation? 09/07/2019

Surface plasmon resonance, isothermal titration calorimetry, and kinetic binding assays quantify IL18BP-IL18 interactions.

Can you explain the strategies used to assess the expression levels and tissue distribution of IL18BP in various physiological and pathological contexts? 03/08/2019

RT-qPCR, immunohistochemistry, and tissue microarray analyses determine the expression patterns of IL18BP in different tissues and diseases.

Could you elaborate on the methods used to investigate the structural determinants of IL18BP's interaction with IL18 and its impact on receptor binding? 12/12/2017

X-ray crystallography, NMR spectroscopy, and mutagenesis studies elucidate the structural basis of IL18BP-IL18 recognition.

How do researchers experimentally study the potential cross-talk between IL18BP and other cytokine regulatory systems, such as IL1Ra and soluble IL6 receptor? 09/24/2017

Cross-competition assays, co-stimulation studies, and receptor activation assays unveil potential interplay between IL18BP and other cytokine regulators.

What assays and methodologies are employed to evaluate the therapeutic potential of enhancing or inhibiting IL18BP activity in inflammatory diseases? 08/26/2017

Therapeutic antibody trials, in vitro functional screens, and disease model assessments evaluate IL18BP modulation as a potential anti-inflammatory strategy.

Customer Reviews (3)

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Reviews
06/03/2022

    Consistent binding affinity. -

    03/01/2020

      High purity. -

      05/04/2018

        Effective in neutralization assays. -

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