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Active Recombinant Cynomolgus Monkey IL18BP Protein, His-tagged

Cat.No. : IL18BP-56C
Product Overview : Recombinant Cynomolgus Monkey IL18BP (Thr28-Arg207) with a C-terminal 6-His tag was expressed in Chinese Hamster Ovary cell line.
  • Specification
  • Gene Information
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Description : The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Source : CHO
Species : Cynomolgus Monkey
Tag : His
Bio-activity : Measured by its ability to inhibit the IL-18-induced response of KG‑1 human acute myelogenous leukemia cells. The ED50 for this effect is 0.015-0.075 μg/mL
Molecular Mass : 20 kDa
Protein length : 28-207
N-terminal Sequence Analysis : Thr28
Endotoxin : < 0.10 EU/μg of the protein by the LAL method.
Purity : > 95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Storage : Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 centigrade as supplied.
1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Storage Buffer : Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution : Reconstitute at 500 μg/mL in PBS.
Shipping : The product is shipped at ambient temperature.
Gene Name : IL18BP interleukin 18 binding protein [ Homo sapiens (human) ]
Official Symbol : IL18BP
Synonyms : IL18BP; interleukin 18 binding protein; FVH; IL18BPa; interleukin-18-binding protein; MC51L-53L-54L homolog gene product; tadekinig-alfa
Gene ID : 10068
mRNA Refseq : NM_173044
Protein Refseq : NP_766632
MIM : 604113
UniProt ID : O95998

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.



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