Active Recombinant Cynomolgus IL18BP protein, His-tagged
|Product Overview :||Recombinant Cynomolgus IL18BP protein(A0A2K5UDJ4)(Thr28-Pro207) is expressed from HEK293 with His tag at the C-Terminus.|
- Gene Information
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|Form :||Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.|
|Bio-activity :||Immobilized Human IL-18, No Tag at 1μg/ml (100μl/well) on the plate. Dose response curve for Cynomolgus IL-18BP, His Tag with the EC50 of 3.2ng/ml determined by ELISA.|
|Molecular Mass :||The protein has a predicted MW of 21.14 kDa. Due to glycosylation, the protein migrates to 35-65 kDa based on Tris-Bis PAGE result.|
|Endotoxin :||Less than 1EU per μg by the LAL method.|
|Purity :||> 95% as determined by Tris-Bis PAGE
> 95% as determined by HPLC
|Storage :||-20 to -80°C for 12 months as supplied from date of receipt.
-20 to -80°C for 3-6 months in unopened state after reconstitution.
2-8°C for 2-7 days after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
|Reconstitution :||Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.|
|Gene Name :||IL18BP interleukin 18 binding protein [ Homo sapiens ]|
|Official Symbol :||IL18BP|
|Synonyms :||IL18BP; interleukin 18 binding protein; interleukin-18-binding protein; IL18BPa; MC51L 53L 54L homolog gene product; IL-18BP; tadekinig-alfa; MC51L-53L-54L homolog gene product|
|Gene ID :||10068|
|mRNA Refseq :||NM_001039659|
|Protein Refseq :||NP_001034748|
|UniProt ID :||O95998|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (10)Ask a question
Genetic association studies, sequencing analyses, and functional investigations explore how genetic variations in IL18BP might influence disease susceptibility and outcomes.
Knockout mice, transgenic models, and imaging techniques provide insights into IL18BP's impact on IL18-related immune responses in vivo.
Promoter studies, siRNA knockdown, and cytokine stimulation assays investigate IL18BP regulation at the transcriptional and post-transcriptional levels.
Luciferase reporter assays, ELISAs, and functional cell assays probe how IL18BP modulates IL18-induced cytokine production and immune cell activation.
Biophysical techniques, site-directed mutagenesis, and receptor binding assays reveal potential allosteric effects on IL18 signaling.
Surface plasmon resonance, isothermal titration calorimetry, and kinetic binding assays quantify IL18BP-IL18 interactions.
RT-qPCR, immunohistochemistry, and tissue microarray analyses determine the expression patterns of IL18BP in different tissues and diseases.
X-ray crystallography, NMR spectroscopy, and mutagenesis studies elucidate the structural basis of IL18BP-IL18 recognition.
Cross-competition assays, co-stimulation studies, and receptor activation assays unveil potential interplay between IL18BP and other cytokine regulators.
Therapeutic antibody trials, in vitro functional screens, and disease model assessments evaluate IL18BP modulation as a potential anti-inflammatory strategy.
Customer Reviews (3)Write a review
Consistent binding affinity. -
High purity. -
Effective in neutralization assays. -
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