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Official Full Name interleukin 28A (interferon, lambda 2)
Background This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28B (IL28B), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA).
Synonyms IL28A; interleukin 28A (interferon, lambda 2); interleukin 28A; interleukin-28A; IFNL2; IL 28A; IFN-lambda-2; cytokine Zcyto20; interferon lambda 2; interferon lambda-2; interferon-lambda 2; IL-28A
    • Species :
    • Human
    • Mouse
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Human
    • Mammalian Cell
    • NSO
    • Tag :
    • Fc
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IL28A-131H Recombinant Human Interleukin 28A (interferon, lambda 2) HEK293 N/A
    Human IL28A-136H Recombinant Human IL28A protein E.coli N/A
    Human IL28A-221H Recombinant Human Interleukin 28A (Interferon, Lambda 2), His-tagged NSO His
    Human IL28A-29785TH Recombinant Human IL28A E.coli N/A
    Human IL28A-311H Recombinant Human IL28A, MIgG2a Fc-tagged CHO Fc
    Human IL28A-312H Recombinant Human IL28A, HIgG1 Fc-tagged CHO Fc
    human IL28A-313H Recombinant Human IL28A, Fc-tagged CHO Fc
    Human IL28A-5229HCL Recombinant Human IL28A 293 Cell Lysate HEK293 N/A
    Human IL28A-539H Recombinant Human Interleukin 28A Human N/A
    Mouse Il28a-229M Recombinant Mouse Interleukin 28a NSO N/A
    Mouse Il28a-5202M Recombinant Mouse Il28a Protein E.coli N/A
    Mouse IL28A-8162M Recombinant Mouse IL28A Protein Mammalian Cell His

    il28a involved in several pathways and played different roles in them. We selected most pathways il28a participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with il28a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction CCL3L1; FASLG; IL9R; GM10591; CXCR2; NT5C3; FLT1; GHRA; IFNAR1; IL2RGB
    Jak-STAT signaling pathway IFNA16; STAT2; PIK3R3; AOX3; IFNA7; IL22RA2; IL2RGA; CRFB4; STAT6; IL-15RA

    il28a has several biochemical functions, for example, cytokine activity, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by il28a itself. We selected most functions il28a had, and list some proteins which have the same functions with il28a. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activity WNT2; CMTM2B; IFNA8; IL6; Ccl9; Il1f8; IFNA3; CSF1B; WNT5A; C1QTNF4
    receptor binding PTK2B; CNPY3; ANKRD13C; FGF8A; JAK2; NSG1; TNFSF18; FYB; TNFSF15; TGFB2

    il28a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with il28a here. Most of them are supplied by our site. Hope this information will be useful for your research of il28a.

    Zhang, LL; Jilg, N; et al. IL28B inhibits hepatitis C virus replication through the JAK-STAT pathway. JOURNAL OF HEPATOLOGY 55:289-298(2011).


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