IL28A
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Official Full Name
interleukin 28A (interferon, lambda 2) -
Overview
This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28B (IL28B), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). -
Synonyms
IL28A;interleukin 28A (interferon, lambda 2);interleukin 28A;interleukin-28A;IFNL2;IL 28A;IFN-lambda-2;cytokine Zcyto20;interferon lambda 2;interferon lambda-2;interferon-lambda 2;IL-28A
Recombinant Proteins
- Human
- Mouse
- human
- Yeast
- E.coli
- CHO
- Human
- Human Cells
- HEK293
- Mammalian Cells
- His
- Non
- Fc
- Avi
Involved Pathway
IL28A involved in several pathways and played different roles in them. We selected most pathways IL28A participated on our site, such as Cytokine-cytokine receptor interaction,Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL28A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Jak-STAT signaling pathway | IL7R,IFNA8,IL11RA,CCND3,HRAS,PTPN11A,AOX3L1,SOCS7,PIK3CA,FHL1 |
| Cytokine-cytokine receptor interaction | BMPR2A,CSF1RA,IFNGR1,IL22,PRL,EDA2R,ACVR2B,IL24,CLCF1,IFNA13 |
Protein Function
IL28A has several biochemical functions, for example, cytokine activity,receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL28A itself. We selected most functions IL28A had, and list some proteins which have the same functions with IL28A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytokine activity | CCL19A.1,GPR19,GDF10,IL37,IFNA12,CMTM1,IL1RN,CSF3,IFNT2,Fasl |
| receptor binding | F2R,ARPP19,PIPOX,GRP,DHRS4,WNT2BA,AKAP9,NUDT7,P2RX4,TNFSF13B |
Interacting Protein
IL28A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL28A here. Most of them are supplied by our site. Hope this information will be useful for your research of IL28A.
Resources
Research Area
Negative Regulators of the Jak/STAT PathwayReceptors in the Jak/STAT Pathway
IL-10 Family Ligands
Related Services
Related Products
References
- Zhang, LL; Jilg, N; et al. IL28B inhibits hepatitis C virus replication through the JAK-STAT pathway. JOURNAL OF HEPATOLOGY 55:289-298(2011).
