IL28A
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Official Full Name
interleukin 28A (interferon, lambda 2)
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Background
This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28B (IL28B), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). -
Synonyms
IL28A; interleukin 28A (interferon, lambda 2); interleukin 28A; interleukin-28A; IFNL2; IL 28A; IFN-lambda-2; cytokine Zcyto20; interferon lambda 2; interferon lambda-2; interferon-lambda 2; IL-28A;
- Involved Pathway
- Protein Function
- Interacting Protein
- IL28A Related Articles
- IL28A Related Gene Family
- IL28A Related Research Area
IL28A involved in several pathways and played different roles in them. We selected most pathways IL28A participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL28A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | TNFRSF13C;CCL7;Kitl;Fasl;IL12B;FLT4;BMPR1AA;IFNA21;TGFB3 |
| Jak-STAT signaling pathway | IL3;IL20;GM13305;HRASA;PIAS4;IL5;IL29;IL3RA;AKT3A |
IL28A has several biochemical functions, for example, cytokine activity, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL28A itself. We selected most functions IL28A had, and list some proteins which have the same functions with IL28A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytokine activity | CD70;IFNA1;CMTM2;CMTM8;CMTM7;GDF7;Il1f8;TNFSF14;GDF5 |
| receptor binding | APOL2;FGF20B;PTK2B;TRIM24;NPFF;CXCL12;NRG3;HSD17B4;FASLG |
IL28A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL28A here. Most of them are supplied by our site. Hope this information will be useful for your research of IL28A.
- Q&As
- Reviews
Q&As (6)
Ask a questionIt can enhance the body's immunity to pathogens by activating the immune system.
IL28A regulates the activity and differentiation of immune cells and enhances the function of the immune system.
It has a long half-life and low clearance, which can maintain a stable plasma concentration.
IL28A is undergoing several clinical trials and is currently showing some efficacy.
This protein is usually synthesized using recombinant DNA technology and purified by column chromatography and other methods.
IL28A can regulate immune response and enhance anti-tumor immunity in tumor therapy.
Customer Reviews (3)
Write a reviewUse cell experiments to verify the regulatory effects on cell signal transduction pathways, such as immune response, inflammation, etc. -
Its molecular weight and composition were determined by western blotting and mass spectrometry, and its biological activity against specific cell lines, such as antiviral effect, was tested. -
Its stability at different temperatures and pH conditions needs to be tested to determine its performance during storage and use. -
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