• Official Full Name

    interleukin 28A (interferon, lambda 2)

  • Background

    This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28B (IL28B), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA).
  • Synonyms

    IL28A; interleukin 28A (interferon, lambda 2); interleukin 28A; interleukin-28A; IFNL2; IL 28A; IFN-lambda-2; cytokine Zcyto20; interferon lambda 2; interferon lambda-2; interferon-lambda 2; IL-28A;
    • Type:
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • human
    • Human
    • Mouse
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Human
    • Human cells
    • Mammalian Cell
    • Mammalian cells
    • Yeast
    • Tag :
    • Fc
    • His
    • His (Fc)
    • Avi
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IFNL2-459H Recombinant Human IL28A protein, His-tagged Yeast His
    Human IL28A-539H Active Recombinant Human Interleukin 28A Human N/A
    Human IL28A-29785TH Recombinant Human IL28A E.coli N/A
    Human IL28A-5229HCL Recombinant Human IL28A 293 Cell Lysate HEK293 N/A
    Human IL28A-136H Active Recombinant Human IL28A protein E.coli N/A
    Human IL28A-312H Active Recombinant Human IL28A, HIgG1 Fc-tagged CHO Fc
    human IL28A-313H Recombinant Human IL28A, Fc-tagged CHO Fc
    Human IL28A-131H Recombinant Human Interleukin 28A (interferon, lambda 2) HEK293 N/A
    Human IL28A-3150H Recombinant Human IL28A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Human IL28A-33H Recombinant Human IL28A Protein, Animal Free Human cells
    Human IL28A-221H Recombinant Human Interleukin 28A (Interferon, Lambda 2), His-tagged Mammalian cells His
    Human IL28A-1244H Recombinant Human IL28A protein, His-tagged HEK293 His
    Human IL28A-3150H-B Recombinant Human IL28A Protein Pre-coupled Magnetic Beads HEK293
    Human IL28A-311H Active Recombinant Human IL28A, MIgG2a Fc-tagged CHO Fc
    Mouse IL28A-8162M Recombinant Mouse IL28A Protein Mammalian Cell His
    Mouse Il28a-5202M Recombinant Mouse Il28a Protein E.coli N/A
    Mouse Il28a-10585M Recombinant Mouse Il28a Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Mouse Il28a-229M Recombinant Mouse Interleukin 28a Mammalian cells N/A
    Mouse Il28a-10585M-B Recombinant Mouse Il28a Protein Pre-coupled Magnetic Beads HEK293
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • IL28A Related Articles
    • IL28A Related Gene Family
    • IL28A Related Research Area

    IL28A involved in several pathways and played different roles in them. We selected most pathways IL28A participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL28A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interactionTNFRSF13C;CCL7;Kitl;Fasl;IL12B;FLT4;BMPR1AA;IFNA21;TGFB3
    Jak-STAT signaling pathwayIL3;IL20;GM13305;HRASA;PIAS4;IL5;IL29;IL3RA;AKT3A

    IL28A has several biochemical functions, for example, cytokine activity, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL28A itself. We selected most functions IL28A had, and list some proteins which have the same functions with IL28A. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activityCD70;IFNA1;CMTM2;CMTM8;CMTM7;GDF7;Il1f8;TNFSF14;GDF5
    receptor bindingAPOL2;FGF20B;PTK2B;TRIM24;NPFF;CXCL12;NRG3;HSD17B4;FASLG

    IL28A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL28A here. Most of them are supplied by our site. Hope this information will be useful for your research of IL28A.

    Zhang, LL; Jilg, N; et al. IL28B inhibits hepatitis C virus replication through the JAK-STAT pathway. JOURNAL OF HEPATOLOGY 55:289-298(2011).
    • Q&As
    • Reviews

    Q&As (6)

    Ask a question
    What is the main mechanism of action of IL28A? 05/24/2021

    It can enhance the body's immunity to pathogens by activating the immune system.

    What is the role IL28A on the immune system? 03/11/2021

    IL28A regulates the activity and differentiation of immune cells and enhances the function of the immune system.

    What are the pharmacokinetic characteristics of IL28A? 03/09/2021

    It has a long half-life and low clearance, which can maintain a stable plasma concentration.

    How's the progress of clinical trials of IL28A? 06/20/2020

    IL28A is undergoing several clinical trials and is currently showing some efficacy.

    How the synthesis and purification method of IL28A? 06/19/2020

    This protein is usually synthesized using recombinant DNA technology and purified by column chromatography and other methods.

    What are the application prospects of IL28A in tumor therapy? 08/10/2019

    IL28A can regulate immune response and enhance anti-tumor immunity in tumor therapy.

    Customer Reviews (3)

    Write a review

      Use cell experiments to verify the regulatory effects on cell signal transduction pathways, such as immune response, inflammation, etc. -


        Its molecular weight and composition were determined by western blotting and mass spectrometry, and its biological activity against specific cell lines, such as antiviral effect, was tested. -


          Its stability at different temperatures and pH conditions needs to be tested to determine its performance during storage and use. -

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