Active Recombinant Mouse Il28a Protein (Asp20-Val193), C-His tagged, Animal-free, Carrier-free

• Cat.No.: Il28a-152M
• Product Overview: Recombinant Mouse Il28a Protein (Asp20-Val193) with C-His tag was expressed in E. coli and Animal-free as well as Carrier-free.

Specification

• Description: Interleukin 28A (IL-28A) predicts a molecular mass of 22.3 kDa. IL-28 comes in two isoforms, IL-28A and IL-28B, and plays a role in immune defense against viruses, including the induction of an "antiviral state" by turning on Mx proteins, 2',5'-oligoadenylate synthetase as well as ISGF3G.
• Source: E. coli
• Species: Mouse
• Tag: His
• Form: Lyophilized
• Bio-activity: Measure by its ability to protect HepG2 cells infected with encephalomyocarditis(EMC) virus. The ED50 for this effect is < 2 ng/mL.
• Molecular Mass: The protein has a calculated MW of 20.61 kDa.
  The protein migrates as 17-25 kDa under reducing condition (SDS-PAGE analysis).
• Protein Length: Asp20-Val193
• Endotoxin: < 0.1 EU/μg of the protein by the LAL method.
• Purity: >98% as determined by SDS-PAGE analysis.
• Storage: This product is stable after storage at:
  -20 centigrade for 12 months in lyophilized state from date of receipt.
  -20 or -80 centigrade for 1 month under sterile conditions after reconstitution.
  Avoid repeated freeze/thaw cycles.
• Storage Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
• Reconstitution: It is recommended to reconstitute the lyophilized protein in sterile H2O to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.
• Shipping: The product is shipped with polar packs. Upon receipt, store it immediately at -20 centigrade or lower for long term storage.

Gene Information

• Gene Name: Il28a interleukin 28A [ Mus musculus (house mouse) ]
• Official Symbol: Il28a
• Synonyms: IL28A; interleukin 28A; interleukin-28A; IFN-lambda2; IFN-lambda-2; interferon-lambda2; interferon lambda-2; Ifnl2; IL-28A; EG330496
• Gene ID: 330496
• mRNA Refseq: NM_001024673
• Protein Refseq: NP_001019844
• UniProt ID: E9Q2S2

Reviews

11/15/2022

No need to prepare a special environment, storage conditions are very simple, can be stored for a long time.

10/04/2020

Very stable, strong anti-pollution ability, the experimental results are very good.

07/16/2019

The labeling effect is very good, and fluorescent labeling can be carried out.

Q&As

What is the main mechanism of action of IL28A?

It can enhance the body's immunity to pathogens by activating the immune system.

What is the role IL28A on the immune system?

IL28A regulates the activity and differentiation of immune cells and enhances the function of the immune system.

What are the pharmacokinetic characteristics of IL28A?

It has a long half-life and low clearance, which can maintain a stable plasma concentration.

How's the progress of clinical trials of IL28A?

IL28A is undergoing several clinical trials and is currently showing some efficacy.

How the synthesis and purification method of IL28A?

This protein is usually synthesized using recombinant DNA technology and purified by column chromatography and other methods.

What are the application prospects of IL28A in tumor therapy?

IL28A can regulate immune response and enhance anti-tumor immunity in tumor therapy.