Recombinant Human IL28A Protein (Val26-Val200), His tagged
Cat.No. : | IL28A-3686H |
Product Overview : | Recombinant human IL28a (Val26-Val200) protein fused with His tag was expressed in E. coli. |
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Species : | Human |
Source : | E.coli |
Tag : | His |
ProteinLength : | Val26-Val200 |
Description : | Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR) -induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression. |
Molecular Mass : | 21.65 kDa |
Purity : | >90 % as determined by SDS-PAGE. |
Notes : | For research use only. |
Storage : | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt. |
Storage Buffer : | Supplied as solution form in PBS pH 7.5 or lyophilized from PBS pH 7.5. |
Reconstitution : | Reconstitute in sterile water for a stock solution. |
Shipping : | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
Gene Name | IL28A interleukin 28A (interferon, lambda 2) [ Homo sapiens (human) ] |
Official Symbol | IL28A |
Synonyms | IL28A; interleukin 28A (interferon, lambda 2); interleukin 28A; interleukin-28A; IFNL2; IL 28A; IFN-lambda-2; cytokine Zcyto20; interferon lambda 2; interferon lambda-2; interferon-lambda 2; IL-28A; |
Gene ID | 282616 |
mRNA Refseq | NM_172138 |
Protein Refseq | NP_742150 |
MIM | 607401 |
UniProt ID | Q8IZJ0 |
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Not For Human Consumption!
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