Recombinant Human Interleukin 28A (interferon, lambda 2)

Cat.No. : IL28A-131H
Product Overview : Recombinant human IL28Ais expressed in human 293 cells with an apparent molecular mass of 24 kDa.This cytokine is produced in a serum-free, chemically defined media.Production in human 293 cells offers authentic human post-translationalmodification which contributes to stability in cell growth media and otherapplications. The purity is greater than 95%.
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Cat. No. : IL28A-131H
Description : IL28 is a cytokinethat comes in two isoforms, IL28A and IL28B, and plays a role in immunedefense against viruses, including the induction an antiviral state byturning on Mx proteins, 2",5"-oligoadenylate synthetase as well as ISGF3G(Interferon Stimulated Gene Factor 3). IL28A and IL28B belong to the type IIIinterferon family of cytokines and are highly similar (in amino acidsequence) to IL-29.
Source : HEK 293 cells
Species : Human
Purity : >95% The proteinwas resolved by SDS polyacrylamide gel electrophoresis and the gel was stainedwith Coomassie blue.
Molecular Mass : 24 kDa monomer,non-glycosylated.
Endotoxin Level : Endotoxin Free <1EU/μg
Biological Activity : 0.5 to 5 ng/mL ED50
Specific Activity : The specificactivity was determined by the dose dependent protection of the cytopathiceffect on A549 cells (human lung adenocarcinoma epithelial cell line) thatwere challenged with encephalomyocarditis (EMC) virus.
OfficialSymbol : IL28A
Pathways : Cytokine-cytokinereceptor interaction; Jak-STAT signaling pathway
Gene Name : IL28A interleukin 28A(interferon, lambda 2) [ Homo sapiens ]
Synonyms : IL28A;interleukin 28A (interferon, lambda 2); IFNL2; IL-28A; interleukin-28A;IFN-lambda-2; cytokine Zcyto20; interferon lambda 2; interferon lambda-2;interferon-lambda 2; Interleukin-28A; Cytokine Zcyto20; Interferon lambda-2
Gene ID : 282616
mRNA Refseq : NM_172138
Protein Refseq : NP_742150
MIM : 607401
UniProt ID : Q8IZJ0
Chromosome Location : 19q13.13
Function : cytokine activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What is the main mechanism of action of IL28A? 05/24/2021

It can enhance the body's immunity to pathogens by activating the immune system.

What is the role IL28A on the immune system? 03/11/2021

IL28A regulates the activity and differentiation of immune cells and enhances the function of the immune system.

What are the pharmacokinetic characteristics of IL28A? 03/09/2021

It has a long half-life and low clearance, which can maintain a stable plasma concentration.

How's the progress of clinical trials of IL28A? 06/20/2020

IL28A is undergoing several clinical trials and is currently showing some efficacy.

How the synthesis and purification method of IL28A? 06/19/2020

This protein is usually synthesized using recombinant DNA technology and purified by column chromatography and other methods.

What are the application prospects of IL28A in tumor therapy? 08/10/2019

IL28A can regulate immune response and enhance anti-tumor immunity in tumor therapy.

Customer Reviews (3)

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11/15/2022

    Use cell experiments to verify the regulatory effects on cell signal transduction pathways, such as immune response, inflammation, etc. -

    10/04/2020

      Its molecular weight and composition were determined by western blotting and mass spectrometry, and its biological activity against specific cell lines, such as antiviral effect, was tested. -

      07/16/2019

        Its stability at different temperatures and pH conditions needs to be tested to determine its performance during storage and use. -

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