Recombinant Human Interleukin 28A (interferon, lambda 2)
|Product Overview :||Recombinant human IL28Ais expressed in human 293 cells with an apparent molecular mass of 24 kDa.This cytokine is produced in a serum-free, chemically defined media.Production in human 293 cells offers authentic human post-translationalmodification which contributes to stability in cell growth media and otherapplications. The purity is greater than 95%.|
- Gene Information
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|Cat. No. :||IL28A-131H|
|Description :||IL28 is a cytokinethat comes in two isoforms, IL28A and IL28B, and plays a role in immunedefense against viruses, including the induction an antiviral state byturning on Mx proteins, 2",5"-oligoadenylate synthetase as well as ISGF3G(Interferon Stimulated Gene Factor 3). IL28A and IL28B belong to the type IIIinterferon family of cytokines and are highly similar (in amino acidsequence) to IL-29.|
|Source :||HEK 293 cells|
|Purity :||>95% The proteinwas resolved by SDS polyacrylamide gel electrophoresis and the gel was stainedwith Coomassie blue.|
|Molecular Mass :||24 kDa monomer,non-glycosylated.|
|Endotoxin Level :||Endotoxin Free <1EU/μg|
|Biological Activity :||0.5 to 5 ng/mL ED50|
|Specific Activity :||The specificactivity was determined by the dose dependent protection of the cytopathiceffect on A549 cells (human lung adenocarcinoma epithelial cell line) thatwere challenged with encephalomyocarditis (EMC) virus.|
|Pathways :||Cytokine-cytokinereceptor interaction; Jak-STAT signaling pathway|
|Gene Name :||IL28A interleukin 28A(interferon, lambda 2) [ Homo sapiens ]|
|Synonyms :||IL28A;interleukin 28A (interferon, lambda 2); IFNL2; IL-28A; interleukin-28A;IFN-lambda-2; cytokine Zcyto20; interferon lambda 2; interferon lambda-2;interferon-lambda 2; Interleukin-28A; Cytokine Zcyto20; Interferon lambda-2|
|Gene ID :||282616|
|mRNA Refseq :||NM_172138|
|Protein Refseq :||NP_742150|
|UniProt ID :||Q8IZJ0|
|Chromosome Location :||19q13.13|
|Function :||cytokine activity|
|IL28A-5229HCL||Recombinant Human IL28A 293 Cell Lysate||+Inquiry|
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (6)Ask a question
It can enhance the body's immunity to pathogens by activating the immune system.
IL28A regulates the activity and differentiation of immune cells and enhances the function of the immune system.
It has a long half-life and low clearance, which can maintain a stable plasma concentration.
IL28A is undergoing several clinical trials and is currently showing some efficacy.
This protein is usually synthesized using recombinant DNA technology and purified by column chromatography and other methods.
IL28A can regulate immune response and enhance anti-tumor immunity in tumor therapy.
Customer Reviews (3)Write a review
Use cell experiments to verify the regulatory effects on cell signal transduction pathways, such as immune response, inflammation, etc. -
Its molecular weight and composition were determined by western blotting and mass spectrometry, and its biological activity against specific cell lines, such as antiviral effect, was tested. -
Its stability at different temperatures and pH conditions needs to be tested to determine its performance during storage and use. -
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