Recombinant Mouse Interleukin 28a

• Cat.No.: Il28a-229M

Specification

• Cat. No.: Il28a-229M
• Description: Interleukin-28A (IL-28A) also known as IFNL2 is a novel cytokine that exerts its biological effects through a receptor that also binds IL28B and IL29. IL28A induces phosphorylation of STAT1, STAT2, and STAT3 IL-28A has antiviral activities and stimulates antiviral responses through a heterodimeric receptor. IL-28A represents a potential novel approach for therapy of Th1-mediated inflammatory diseases such as T-cell-mediated hepatitis.
• Source: Mammalian cells
• Molecular Weight: The predicted molecular weight of Recombinant Mouse IL-28A is Mr 20.5 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 25-30 kDa.
• State Of Matter: Lyophilized.
• Purity: >95% by SDS Page and analyzed by silver stain.
• Endotoxin: <1.0 EU/µg as determined by the LAL method.
• Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Gene Information

• Gene Name: Il28a interleukin 28A [ Mus musculus ]
• Synonyms: Il28a; interleukin 28A; Ifnl2; EG330496; IFN-lambda2; interferon-lambda2
• Gene ID: 330496
• mRNA Refseq: NM_001024673
• Protein Refseq: NP_001019844
• UniProt ID: Q4VK74
• Chromosome Location: 7
• Pathway: Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway
• Function: cytokine activity

Reviews

11/15/2022

No need to prepare a special environment, storage conditions are very simple, can be stored for a long time.

10/04/2020

Very stable, strong anti-pollution ability, the experimental results are very good.

07/16/2019

The labeling effect is very good, and fluorescent labeling can be carried out.

Q&As

What is the main mechanism of action of IL28A?

It can enhance the body's immunity to pathogens by activating the immune system.

What is the role IL28A on the immune system?

IL28A regulates the activity and differentiation of immune cells and enhances the function of the immune system.

What are the pharmacokinetic characteristics of IL28A?

It has a long half-life and low clearance, which can maintain a stable plasma concentration.

How's the progress of clinical trials of IL28A?

IL28A is undergoing several clinical trials and is currently showing some efficacy.

How the synthesis and purification method of IL28A?

This protein is usually synthesized using recombinant DNA technology and purified by column chromatography and other methods.

What are the application prospects of IL28A in tumor therapy?

IL28A can regulate immune response and enhance anti-tumor immunity in tumor therapy.