Active Recombinant Mouse Il28a Protein

Cat.No. : Il28a-5202M
Product Overview : Mouse Il28a (Q4VK74) partial recombinant protein expressed in Escherichia coli.
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Description : Interleukin-28 (IL-28) is a cytokine that comes in two isoforms, IL-28A and IL-28B, and plays a role in immune defense against viruses, including the induction of an "antiviral state" by turning on Mx proteins, 2',5'-oligoadenylate synthetase as well as ISGF3G (Interferon Stimulated Gene Factor 3). IL-28A and IL-28B belong to the type III interferon family of cytokines and are highly similar (in amino acid sequence) to IL-29. Their classification as Interferons is due to their ability to induce an antiviral state, while their additional classification as cytokines is due to their chromosomal location as well as the fact that they are encoded by multiple exons, as opposed to a single exon, as most type-I IFNs are.
Source : E. coli
Species : Mouse
Form : Lyophilized
Bio-activity : Determined by its ability to activate STAT following receptor-ligand interaction.
Molecular Mass : 25.0 kDa
AA Sequence : MDPVPRATRLPVEAKDCHIAQFKSL SPKELQAFKKAKDAIEKRLLEKDMR CSSHLISRAWDLKQLQVQERPKALQ AEVALTLKVWENMTDSALATILGQP LHTLSHIHSQLQTCTQLQATAEPKP PSRRLSRWLHRLQEAQSKETPGCLE DSVTSNLFRLLTRDLKCVASGDQCV
Endotoxin : Endotoxin level is < 0.1 ng/μg (< 1 EU/μg).
Purity : 98%
Applications : Functional Study
SDS-PAGE
Usage : Activity assay
SDS-PAGE
The optimal working dilution should be determined by the end user.
Storage : Store at -20 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : Lyophilized from solutions contain no sodiun azide nor carrier protein
Gene Name : Il28a interleukin 28A [ Mus musculus ]
Official Symbol : Il28a
Synonyms : IL28A; interleukin 28A; interleukin-28A; IFN-lambda2; IFN-lambda-2; interferon-lambda2; interferon lambda-2; Ifnl2; IL-28A; EG330496;
Gene ID : 330496
mRNA Refseq : NM_001024673
Protein Refseq : NP_001019844

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What is the main mechanism of action of IL28A? 05/24/2021

It can enhance the body's immunity to pathogens by activating the immune system.

What is the role IL28A on the immune system? 03/11/2021

IL28A regulates the activity and differentiation of immune cells and enhances the function of the immune system.

What are the pharmacokinetic characteristics of IL28A? 03/09/2021

It has a long half-life and low clearance, which can maintain a stable plasma concentration.

How's the progress of clinical trials of IL28A? 06/20/2020

IL28A is undergoing several clinical trials and is currently showing some efficacy.

How the synthesis and purification method of IL28A? 06/19/2020

This protein is usually synthesized using recombinant DNA technology and purified by column chromatography and other methods.

What are the application prospects of IL28A in tumor therapy? 08/10/2019

IL28A can regulate immune response and enhance anti-tumor immunity in tumor therapy.

Customer Reviews (3)

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Reviews
11/15/2022

    No need to prepare a special environment, storage conditions are very simple, can be stored for a long time.

    10/04/2020

      Very stable, strong anti-pollution ability, the experimental results are very good.

      07/16/2019

        The labeling effect is very good, and fluorescent labeling can be carried out.

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