Active Recombinant Human IL28A Protein, Animal Free

• Cat.No.: IL28A-33H
• Product Overview: Recombinant Human IL28A Protein without tag was expressed in Human cells.
  Animal Free and Xeno Free

Specification

• Species: Human
• Source: Human Cells
• Description: IL-28A, also named interferon λ2 (IFNλ2), belongs to the type III interferon protein family, which is distinct from the type I IFNs. IL-28A is induced by virus infection or double stranded RNA. IL-28A acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. IL-28A has antiviral, antitumor and immunomodulatory activities, plays a critical role in the antiviral host defense, predominantly in the epithelial tissues.
• Bio-activity: The activity was measured by its anti-virus function in A549 cells (human lung adenocarcinoma epithelial cell line) infected with encephalomyocarditis (EMC) virus.
• Molecular Mass: 24 kDa
• Endotoxin: <0.5 EU/ μg
• Purity: High Purity, >95% by SDS-PAGE
• Stability: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. In general: 12 months from date of receipt, -20 to -80 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -80 centigrade under sterile conditions after reconstitution.
• Storage Buffer: Lyophilized from a 0.2 μm filtered solution in PBS without carrier protein
• Reconstitution: Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.

Gene Information

• Gene Name: IL28A interleukin 28A (interferon, lambda 2) [ Homo sapiens (human) ]
• Official Symbol: IL28A
• Synonyms: IL28A; interleukin 28A (interferon, lambda 2); interleukin 28A; interleukin-28A; IFNL2; IL 28A; IFN-lambda-2; cytokine Zcyto20; interferon lambda 2; interferon lambda-2; interferon-lambda 2; IL-28A
• Gene ID: 282616
• mRNA Refseq: NM_172138
• Protein Refseq: NP_742150
• MIM: 607401
• UniProt ID: Q8IZJ0