Active Recombinant Human Interleukin 28A

• Cat.No.: IL28A-539H
• Product Overview: Recombinant human IL28A was expressed in E. coli and purified by using conventional chromatography techniques.

Specification

• Cat. No.: IL28A-539H
• Description: IFN-lambda-1, -2, and -3 (also known as IL29, IL28A and IL28B respectively) are distantly related to the IL10 family and Interferons. All three IFN-lambdas uses a distinct receptor system composed of an IFN-lambdaR1 subunit (also called CRF2-12) and IL10R2 subunit (also called CRF2-14). Signaling through this receptor system induces antiviral defense similar but distinct than the type I Interferons.
• Source: Human
• Host: E.coli
• Form: Supplied as a lyophilized powder.
• Purity: >98% pure by SDS PAGE and HPLC
• Sequence: Region of IFN Gamma 2 protein corresponding to amino acids PVARLHGALP DARGCHIAQF KSLSPQELQA FKRAKDALEE SLLLKDCRCH SRLFPRTWDL RQLQVRERPM ALEAELALTL KVLEATADTD PALVDVLDQP LHTLHHILSQ FRACIQPQPT AGPRTRGRLH HWLYRLQEAP KKESPGCLEA SVTFNLFRLL TRDLNCVASG DLCV.
• Molecular Mass: 19.6 kDa
• Applications: Numerous applications are possible with this product and should be tested by the end user under their own laboratory conditions
• Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
• Bioactivity: Determined by its ability to activate STAT following receptor-ligand interaction.
• Storage: Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
• Tag: Non

Gene Information

• Gene Name: IL28A interleukin 28A (interferon, lambda 2) [ Homo sapiens ]
• Official Symbol: IL28A
• Synonyms: IL28A; interleukin 28A (interferon, lambda 2);IFNL2; IL-28A; IFN-lambda-2; interferon lambda 2; interferon-lambda 2; Interleukin-28A; Interferon lambda-2; IFN-lambda-2; ZCYTO20; Cytokine ZCYTO20
• Gene ID: 282616
• mRNA Refseq: NM_172138
• Protein Refseq: NP_742150
• MIM: 607401
• UniProt ID: Q8IZJ0
• Chromosome Location: 19q13.13
• Pathway: Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway
• Function: Cytokine activity

Reviews

11/15/2022

No need to prepare a special environment, storage conditions are very simple, can be stored for a long time.

10/04/2020

Very stable, strong anti-pollution ability, the experimental results are very good.

07/16/2019

The labeling effect is very good, and fluorescent labeling can be carried out.

Q&As

What is the main mechanism of action of IL28A?

It can enhance the body's immunity to pathogens by activating the immune system.

What is the role IL28A on the immune system?

IL28A regulates the activity and differentiation of immune cells and enhances the function of the immune system.

What are the pharmacokinetic characteristics of IL28A?

It has a long half-life and low clearance, which can maintain a stable plasma concentration.

How's the progress of clinical trials of IL28A?

IL28A is undergoing several clinical trials and is currently showing some efficacy.

How the synthesis and purification method of IL28A?

This protein is usually synthesized using recombinant DNA technology and purified by column chromatography and other methods.

What are the application prospects of IL28A in tumor therapy?

IL28A can regulate immune response and enhance anti-tumor immunity in tumor therapy.