Recombinant Human Interleukin 28A (Interferon, Lambda 2), His-tagged IL28A-221H

Recombinant Human Interleukin 28A (Interferon, Lambda 2), His-tagged


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Recombinant Human Interleukin 28A (Interferon, Lambda 2), His-tagged

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Cat.No. : IL28A-221H Optional Service: Optional requirements on this protein
Product Overview : Recombinant Human interleukin 28A DNA sequence encoding the signal peptide from human CD33 was fused to the carboxylterminally his-tagged mature human IL-29 (Gly 20 - Thr 200) was expressed ina mouse NSO Cells.
Description : Interleukin-28A (IL-28A) also known as IFNL2 is a novel cytokine that exerts its biological effects through a receptor that also binds IL28B and IL29. IL28A induces phosphorylation of STAT1, STAT2, and STAT3. IL-28A has antiviral activities and stimulates antiviral responses through a heterodimeric receptor. IL-28A represents a potential novel approach for therapy of Th1-mediated inflammatory diseases such as T-cell-mediated hepatitis.
Source : Mammalian cells
Molecular Weight : The predicted molecular weight of Recombinant Human IL-28A is Mr 20.8 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 24 kDa.
State Of Matter : Lyophilized.
Formulation : This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Purity : > 97% by SDS Page and analyzed by silver stain.
Endotoxin : < 1.0 EU/µg as determined by the LAL method.
Biological Activity : The biological activity of Human IFN-λ2 was determined by in an anti-viral assay using human HepG2 cells infected with encephalomyocarditis virus. The expected ED50 for this effect is typically 1 - 5 ng/mL.
Storage And Stability : This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Gene Name : IL28A interleukin 28A (interferon, lambda 2) [ Homo sapiens ]
Synonyms : IL28A; interleukin 28A (interferon, lambda 2);IFNL2; IL-28A; IFN-lambda-2; interferon lambda 2; interferon-lambda 2; Interleukin-28A; Interferon lambda-2; IFN-lambda-2; ZCYTO20; Cytokine ZCYTO20
Gene ID : 282616
mRNA Refseq : NM_172138
Protein Refseq : NP_742150
UniProt ID : Q8IZJ0
Chromosome Location : 19q13.13
MIM : 607401
Pathway : Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway
Function : Cytokine activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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