Recombinant Human Interleukin 28A (Interferon, Lambda 2), His-tagged

Cat.No. : IL28A-221H
Product Overview : Recombinant Human interleukin 28A DNA sequence encoding the signal peptide from human CD33 was fused to the carboxylterminally his-tagged mature human IL-29 (Gly 20 - Thr 200) was expressed ina mouse NSO Cells.
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Cat. No. : IL28A-221H
Description : Interleukin-28A (IL-28A) also known as IFNL2 is a novel cytokine that exerts its biological effects through a receptor that also binds IL28B and IL29. IL28A induces phosphorylation of STAT1, STAT2, and STAT3. IL-28A has antiviral activities and stimulates antiviral responses through a heterodimeric receptor. IL-28A represents a potential novel approach for therapy of Th1-mediated inflammatory diseases such as T-cell-mediated hepatitis.
Source : Mammalian cells
Molecular Weight : The predicted molecular weight of Recombinant Human IL-28A is Mr 20.8 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 24 kDa.
State Of Matter : Lyophilized.
Formulation : This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Purity : > 97% by SDS Page and analyzed by silver stain.
Endotoxin : < 1.0 EU/µg as determined by the LAL method.
Biological Activity : The biological activity of Human IFN-λ2 was determined by in an anti-viral assay using human HepG2 cells infected with encephalomyocarditis virus. The expected ED50 for this effect is typically 1 - 5 ng/mL.
Storage And Stability : This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Gene Name : IL28A interleukin 28A (interferon, lambda 2) [ Homo sapiens ]
Synonyms : IL28A; interleukin 28A (interferon, lambda 2);IFNL2; IL-28A; IFN-lambda-2; interferon lambda 2; interferon-lambda 2; Interleukin-28A; Interferon lambda-2; IFN-lambda-2; ZCYTO20; Cytokine ZCYTO20
Gene ID : 282616
mRNA Refseq : NM_172138
Protein Refseq : NP_742150
UniProt ID : Q8IZJ0
Chromosome Location : 19q13.13
MIM : 607401
Pathway : Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway
Function : Cytokine activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.


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Customer Reviews (3)

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    No need to prepare a special environment, storage conditions are very simple, can be stored for a long time.


      Very stable, strong anti-pollution ability, the experimental results are very good.


        The labeling effect is very good, and fluorescent labeling can be carried out.

        Q&As (6)

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        What is the main mechanism of action of IL28A? 05/24/2021

        It can enhance the body's immunity to pathogens by activating the immune system.

        What is the role IL28A on the immune system? 03/11/2021

        IL28A regulates the activity and differentiation of immune cells and enhances the function of the immune system.

        What are the pharmacokinetic characteristics of IL28A? 03/09/2021

        It has a long half-life and low clearance, which can maintain a stable plasma concentration.

        How's the progress of clinical trials of IL28A? 06/20/2020

        IL28A is undergoing several clinical trials and is currently showing some efficacy.

        How the synthesis and purification method of IL28A? 06/19/2020

        This protein is usually synthesized using recombinant DNA technology and purified by column chromatography and other methods.

        What are the application prospects of IL28A in tumor therapy? 08/10/2019

        IL28A can regulate immune response and enhance anti-tumor immunity in tumor therapy.

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