IL36RN
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Official Full Name
interleukin 36 receptor antagonist
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Background
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding the same protein have been reported. -
Synonyms
IL36RN; interleukin 36 receptor antagonist; IL1F5, interleukin 1 family, member 5 (delta); interleukin-36 receptor antagonist protein; family of interleukin 1 delta; FIL1; FIL1(DELTA); FIL1D; IL 1 related protein 3; IL 1F5; IL1HY1; IL1L1; IL1RP3; IL36RA; IL1F5; PSORP;
- Involved Pathway
- Protein Function
- Interacting Protein
- IL36RN Related Gene Family
- IL36RN Related Research Area
IL36RN involved in several pathways and played different roles in them. We selected most pathways IL36RN participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with IL36RN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
IL36RN has several biochemical functions, for example, cytokine activity, interleukin-1 receptor antagonist activity, interleukin-1 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL36RN itself. We selected most functions IL36RN had, and list some proteins which have the same functions with IL36RN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytokine activity | IL6;IL22;IFNA8;CSF1B;Il23a; Il12b;TNFSF4;IL37;CMTM4;CCL20A.3 |
| interleukin-1 receptor antagonist activity | IL1RN;Il1f5;IL36RN |
| interleukin-1 receptor binding | TLR9;IRAK4;IL1RAP;IL1F10;IL1B;IL36RN;IRAK1;IL37;IL36G |
| protein binding | TEAD3;UBASH3B;KRT6B;TFF2;NOX1;CHRNA5;MB21D2;SPDYE2;EIF1AY |
IL36RN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL36RN here. Most of them are supplied by our site. Hope this information will be useful for your research of IL36RN.
REL; SSBP3; SKIL; SSBP2; MCM6; ZNF512B; SSBP4; SMAD3
- Q&As
- Reviews
Q&As (6)
Ask a questionThe mechanism of action of IL36RN is to play an anti-inflammatory, anti-infection, anti-tumor and other biological mechanisms by acting on the signaling pathway of IL-36 receptor.
The purity of IL36RN can be ensured by ion exchange chromatography, dialysis, gel filtration and other methods.
Mass production of IL36RN can be carried out through large-scale fermentation, purification and other processes.
This protein is an inhibitor with no biological activity of its own; Recombinant IL36α, β and γ are agonists with different biological effects.
Can be used in clinical trials and therapy.
IL36RN has sustained and stable biological activity.
Customer Reviews (3)
Write a reviewThis protein is involved in the regulation of immune response, especially in the body's response to bacterial and viral infections, it can inhibit the activation of inflammatory cells and the release of inflammatory factors. -
IL-36Ra is able to inhibit IL-36-mediated signaling by binding to IL-36 receptors, and thus has biological activity to regulate immunity and anti-inflammatory effects. -
It is a soluble protein that is easy to manipulate in vitro studies and applications. -
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