Active GMP Recombinant Human IL36RN protein, Fc-tagged

Cat.No. : IL36RN-169HG
Product Overview : GMP Recombinant Human IL36RN protein(NP_036407.1)(392 aa), fused with Fc Tag at the C-terminal, was expressed in HEK293 cell in an animal component free process under cGMP guidelines.
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Source : HEK293
Species : Human
Tag : Fc
Bio-activity : The ability to inhibit the secretion of IL-8 by A431 cells under the action of IL-36γ was used for determination. When the concentration of IL-36β is 10ng/mL, the ED50 of this effect is 0.2-1ug/mL
Molecular Mass : Recombinant Human IL-36RA contains 392 aa. It has a predicted MW of 43.8 kDa.
Protein length : DNA sequence encoding Human IL-36RA(NP_036407.1) was expressed with Fc tag at the C-terminal.
Endotoxin : <=0.01EU/ug
Purity : >=95% by SDS-PAGE and HPLC
Storage : The lyophilized preparation can be stored at 4°C for 24 months, and the dissolved liquid can be stored at -20°C for 6-12 months to avoid repeated freezing and thawing
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.
Gene Name : IL36RN interleukin 36 receptor antagonist [ Homo sapiens (human) ]
Official Symbol : IL36RN
Synonyms : FIL1; FIL1D; IL1F5; IL1L1; PSORP; IL1HY1; IL1RP3; IL36RA; IL-36Ra; PSORS14; FIL1(DELTA)
Gene ID : 26525
mRNA Refseq : NM_012275.3
Protein Refseq : NP_036407.1
MIM : 605507
UniProt ID : Q9UBH0

Not For Human Consumption!

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Reviews
05/31/2021

    When conducting experiments with IL36RN, clear and consistent results can be obtained, facilitating data analysis and interpretation.

    01/29/2019

      IL36RN has high specific activity and can exert strong biological effect at low concentration.

      01/11/2019

        The stability of the IL36RN product allows it to cope with different experimental conditions and modes of operation.

        Q&As (6)

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        What is the action mechanism of IL36RN? 06/11/2022

        The mechanism of action of IL36RN is to play an anti-inflammatory, anti-infection, anti-tumor and other biological mechanisms by acting on the signaling pathway of IL-36 receptor.

        How to ensure the purity of IL36RN when preparing it? 11/22/2021

        The purity of IL36RN can be ensured by ion exchange chromatography, dialysis, gel filtration and other methods.

        IL36RN production process is what? 03/24/2020

        Mass production of IL36RN can be carried out through large-scale fermentation, purification and other processes.

        What is the difference between IL36RN protein and IL36α, β, γ? 03/22/2020

        This protein is an inhibitor with no biological activity of its own; Recombinant IL36α, β and γ are agonists with different biological effects.

        Can recombinant IL36RN be used in clinical trials and therapeutics? 09/24/2019

        Can be used in clinical trials and therapy.

        Does IL36RN have sustained and stable biological activity? 03/24/2019

        IL36RN has sustained and stable biological activity.

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