Active GMP Recombinant Human IL36RN protein, Fc-tagged

• Cat.No.: IL36RN-169HG
• Product Overview: GMP Recombinant Human IL36RN protein(NP_036407.1)(392 aa), fused with Fc Tag at the C-terminal, was expressed in HEK293 cell in an animal component free process under cGMP guidelines.

Specification

• Source: HEK293
• Species: Human
• Tag: Fc
• Bio-activity: The ability to inhibit the secretion of IL-8 by A431 cells under the action of IL-36γ was used for determination. When the concentration of IL-36β is 10ng/mL, the ED50 of this effect is 0.2-1ug/mL
• Molecular Mass: Recombinant Human IL-36RA contains 392 aa. It has a predicted MW of 43.8 kDa.
• Protein length: DNA sequence encoding Human IL-36RA(NP_036407.1) was expressed with Fc tag at the C-terminal.
• Endotoxin: <=0.01EU/ug
• Purity: >=95% by SDS-PAGE and HPLC
• Storage: The lyophilized preparation can be stored at 4°C for 24 months, and the dissolved liquid can be stored at -20°C for 6-12 months to avoid repeated freezing and thawing
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.

Gene Information

• Gene Name: IL36RN interleukin 36 receptor antagonist [ Homo sapiens (human) ]
• Official Symbol: IL36RN
• Synonyms: FIL1; FIL1D; IL1F5; IL1L1; PSORP; IL1HY1; IL1RP3; IL36RA; IL-36Ra; PSORS14; FIL1(DELTA)
• Gene ID: 26525
• mRNA Refseq: NM_012275.3
• Protein Refseq: NP_036407.1
• MIM: 605507
• UniProt ID: Q9UBH0

Reviews

05/31/2021

When conducting experiments with IL36RN, clear and consistent results can be obtained, facilitating data analysis and interpretation.

01/29/2019

IL36RN has high specific activity and can exert strong biological effect at low concentration.

01/11/2019

The stability of the IL36RN product allows it to cope with different experimental conditions and modes of operation.

Q&As

What is the action mechanism of IL36RN?

The mechanism of action of IL36RN is to play an anti-inflammatory, anti-infection, anti-tumor and other biological mechanisms by acting on the signaling pathway of IL-36 receptor.

How to ensure the purity of IL36RN when preparing it?

The purity of IL36RN can be ensured by ion exchange chromatography, dialysis, gel filtration and other methods.

IL36RN production process is what?

Mass production of IL36RN can be carried out through large-scale fermentation, purification and other processes.

What is the difference between IL36RN protein and IL36α, β, γ?

This protein is an inhibitor with no biological activity of its own; Recombinant IL36α, β and γ are agonists with different biological effects.

Can recombinant IL36RN be used in clinical trials and therapeutics?

Can be used in clinical trials and therapy.

Does IL36RN have sustained and stable biological activity?

IL36RN has sustained and stable biological activity.