Active Recombinant Mouse Il1f5 Protein

• Cat.No.: Il1f5-148M
• Product Overview: Purified recombinant protein of Mouse interleukin 1 family, member 5 (delta) (Il1f5), transcript variant 2 without tag was expressed in E.coli.

Specification

• Description: Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2/IL-36R and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR.
• Source: E. coli
• Species: Mouse
• Bio-activity: Measured by its ability to inhibit IL-36γ induced IL-6 production by human PBMCs.
• Molecular Mass: 17 kDa
• AA Sequence: VLSGALCFRMKDSALKVLYLHNNQL LAGGLHAEKVIKGEEISVVPNRALD ASLSPVILGVQGGSQCLSCGTEKGP ILKLEPVNIMELYLGAKESKSFTFY RRDMGLTSSFESAAYPGWFLCTSPE ADQPVRLTQIPEDPAWDAPITDFYF QQCD
• Endotoxin: Endotoxin level is < 0.1 ng/µg of protein (< 1 EU/µg)
• Purity: >95%, as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for at least 6 months from date of receipt under proper storage and handling conditions.
• Storage: Store at -80 centigrade.
• Storage Buffer: Lyophilized from a 0.2 µM filtered solution of 20mM phosphate buffer,100mM NaCl, pH 7.2
• Reconstitution: Resuspend the protein in the desired concentration in proper buffer.

Gene Information

• Gene Name: Il1f5 interleukin 1 family, member 5 (delta) [ Mus musculus (house mouse) ]
• Official Symbol: Il1f5
• Synonyms: Il1f5; interleukin 1 family, member 5 (delta); IL36RN; Il-1h3; Il1hy1; IL-36Ra; AI413231; Fil1delta; interleukin-36 receptor antagonist protein; IL-1 delta; IL-1F5; IL-1HY1; IL-1L1; interleukin 1 receptor antagonist homolog 1; interleukin-1 HY1; interleukin-1 delta; interleukin-1 family member 5; interleukin-1 homolog 3; interleukin-1-like protein 1
• Gene ID: 54450
• mRNA Refseq: NM_019451
• Protein Refseq: NP_062324
• UniProt ID: Q9QYY1