Recombinant Human IL1F5, His-tagged

• Cat.No.: IL1F5-14169H
• Product Overview: Recombinant Human IL1F5 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Description: The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding the same protein have been reported.
• Source: E.coli
• Species: Human
• Tag: His
• Protein length: 1-155a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: IL36RN interleukin 36 receptor antagonist [ Homo sapiens ]
• Official Symbol: IL36RN
• Synonyms: interleukin 36 receptor antagonist; 15561; Ensembl:ENSG00000136695; MGC29840; interleukin-36 receptor antagonist protein;IL-1ra homolog 1;interleukin-1 HY1;IL-1 related protein 3;interleukin-1-like protein 1;family of interleukin 1-delta;IL1F5 (Canonical product IL-1F5a);interleukin 1 family, member 5 (delta);interleukin-1 receptor antagonist homolog 1;IL-1F5 (IL-1HY1, FIL1-delta, IL-1RP3, IL-1L1, IL-1-delta); FIL1; FIL1D; IL1F5; IL1L1; PSORP; IL1HY1; IL1RP3; IL36RA; FIL1(DELTA)
• Gene ID: 26525
• mRNA Refseq: NM_012275.2
• Protein Refseq: NP_036407.1
• MIM: 605507
• UniProt ID: Q9UBH0
• Chromosome Location: 2q14
• Function: cytokine activity; interleukin-1 receptor antagonist activity

Reviews

05/31/2021

When conducting experiments with IL36RN, clear and consistent results can be obtained, facilitating data analysis and interpretation.

01/29/2019

IL36RN has high specific activity and can exert strong biological effect at low concentration.

01/11/2019

The stability of the IL36RN product allows it to cope with different experimental conditions and modes of operation.

Q&As

What is the action mechanism of IL36RN?

The mechanism of action of IL36RN is to play an anti-inflammatory, anti-infection, anti-tumor and other biological mechanisms by acting on the signaling pathway of IL-36 receptor.

How to ensure the purity of IL36RN when preparing it?

The purity of IL36RN can be ensured by ion exchange chromatography, dialysis, gel filtration and other methods.

IL36RN production process is what?

Mass production of IL36RN can be carried out through large-scale fermentation, purification and other processes.

What is the difference between IL36RN protein and IL36α, β, γ?

This protein is an inhibitor with no biological activity of its own; Recombinant IL36α, β and γ are agonists with different biological effects.

Can recombinant IL36RN be used in clinical trials and therapeutics?

Can be used in clinical trials and therapy.

Does IL36RN have sustained and stable biological activity?

IL36RN has sustained and stable biological activity.