Recombinant Active Human IL36RN Protein, His-tagged(C-ter)

Cat.No. : IL36RN-200H
Product Overview : Recombinant Active Human IL36RN Protein with His tag (C-ter) was expressed in E. coli.
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Description : The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
Source : E. coli
Species : Human
Tag : His
Form : Powder
Bio-activity : Determined by its ability to inhibit IL-36 gamma-induced IL-8 secretion in PBMC cells. The ED50 for this effect is < 2 ng/mL in the presence of 500 ng/mL of recombinant human IL-36 gamma.
AA Sequence : MVLSGALCFRMKDSALKVLYLHNNQ LLAGGLHAGKVIKGEEISVVPNRWL DASLSPVILGVQGGSQCLSCGVGQE PTLTLEPVNIMELYLGAKESKSFTF YRRDMGLTSSFESAAYPGWFLCTVP EADQPVRLTQLPENGGWNAPITDFY FQQCD
Endotoxin : Endotoxin level is less than 0.1 EU/μg of the protein, as determined by the LAL test.
Purity : > 98% (by SDS-PAGE)
Applications : SDS-PAGE
Notes : For laboratory research only, not for drug, diagnostic or other use.
Storage : Lyophilized protein should be stored at -20°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening.
Storage Buffer : PBS (pH 7.4)
Reconstitution : It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 100 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely.
Gene Name : IL36RN interleukin 36 receptor antagonist [ Homo sapiens ]
Official Symbol : IL36RN
Synonyms : IL36RN; interleukin 36 receptor antagonist; IL1F5, interleukin 1 family, member 5 (delta); interleukin-36 receptor antagonist protein; family of interleukin 1 delta; FIL1; FIL1(DELTA); FIL1D; IL 1 related protein 3; IL 1F5; IL1HY1; IL1L1; IL1RP3; IL36RA; interleukin 1 HY1; interleukin 1 receptor antagonist homolog 1; MGC29840; IL-1ra homolog 1; interleukin-1 HY1; IL-1 related protein 3; interleukin-1-like protein 1; family of interleukin 1-delta; IL1F5 (Canonical product IL-1F5a); interleukin 1 family, member 5 (delta); interleukin-1 receptor antagonist homolog 1; IL-1F5 (IL-1HY1, FIL1-delta, IL-1RP3, IL-1L1, IL-1-delta); IL1F5; PSORP;
Gene ID : 26525
mRNA Refseq : NM_012275
Protein Refseq : NP_036407
MIM : 605507
UniProt ID : Q9UBH0

Not For Human Consumption!

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Reviews
05/31/2021

    When conducting experiments with IL36RN, clear and consistent results can be obtained, facilitating data analysis and interpretation.

    01/29/2019

      IL36RN has high specific activity and can exert strong biological effect at low concentration.

      01/11/2019

        The stability of the IL36RN product allows it to cope with different experimental conditions and modes of operation.

        Q&As (6)

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        What is the action mechanism of IL36RN? 06/11/2022

        The mechanism of action of IL36RN is to play an anti-inflammatory, anti-infection, anti-tumor and other biological mechanisms by acting on the signaling pathway of IL-36 receptor.

        How to ensure the purity of IL36RN when preparing it? 11/22/2021

        The purity of IL36RN can be ensured by ion exchange chromatography, dialysis, gel filtration and other methods.

        IL36RN production process is what? 03/24/2020

        Mass production of IL36RN can be carried out through large-scale fermentation, purification and other processes.

        What is the difference between IL36RN protein and IL36α, β, γ? 03/22/2020

        This protein is an inhibitor with no biological activity of its own; Recombinant IL36α, β and γ are agonists with different biological effects.

        Can recombinant IL36RN be used in clinical trials and therapeutics? 09/24/2019

        Can be used in clinical trials and therapy.

        Does IL36RN have sustained and stable biological activity? 03/24/2019

        IL36RN has sustained and stable biological activity.

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