IL9R
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Official Full Name
interleukin 9 receptor
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Background
The protein encoded by this gene is a cytokine receptor that specifically mediates the biological effects of interleukin 9 (IL9). The functional IL9 receptor complex requires this protein as well as the interleukin 2 receptor, gamma (IL2RG), a common gamma subunit shared by the receptors of many different cytokines. The ligand binding of this receptor leads to the activation of various JAK kinases and STAT proteins, which connect to different biologic responses. This gene is located at the pseudoautosomal regions of X and Y chromosomes. Genetic studies suggested an association of this gene with the development of asthma. Multiple pseudogenes on chromosome 9, 10, 16, and 18 have been described. Alternatively spliced transcript variants have been found for this gene. -
Synonyms
IL9R; interleukin 9 receptor; interleukin-9 receptor; CD129; IL-9R; IL-9 receptor;
- Involved Pathway
- Protein Function
- Interacting Protein
- IL9R Related Gene Family
- IL9R Related Research Area
IL9R involved in several pathways and played different roles in them. We selected most pathways IL9R participated on our site, such as Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, IL-9 Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL9R were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | IFNK;TNFSF10;Fasl;IRX1;IL28A;TNFRSF19;CXCL1;ACVR2AA;IL12RB2 |
| Hematopoietic cell lineage | ITGA6;HLA-DRB3;IL3RA;CD3G;ITGA2;IL5;CD1d1;IL6R;CR1 |
| IL-9 Signaling Pathway | |
| Jak-STAT signaling pathway | SOCS1A;TSLP;CSF3;IFNGR1;STAM;CSF3R;IL11RA;HRASA;IL13 |
IL9R has several biochemical functions, for example, interleukin-9 receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL9R itself. We selected most functions IL9R had, and list some proteins which have the same functions with IL9R. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| interleukin-9 receptor activity |
IL9R has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL9R here. Most of them are supplied by our site. Hope this information will be useful for your research of IL9R.
YWHAZ; CRADD
- Q&As
- Reviews
Q&As (6)
Ask a questionIn pre-clinical trials, the IL9R significantly increased natural killer and CD4 + T cell levels in patients.
IL9R may play an important role in the treatment of central nervous system diseases and hematological diseases.
This needs to be further confirmed by large-scale clinical trials.
This can be achieved through in vitro molecular cell techniques and carefully designed in vivo animal models.
There have been no large-scale clinical studies to prove which diseases the recombinant IL9R protein can treat.
Some studies have suggested that the expression of IL9R in tumor cells may be associated with patient prognosis.
Customer Reviews (3)
Write a reviewIL-9R belongs to the cell membrane receptor family, which includes multiple subunits. Different types of IL-9R may have different structures and involve different signal transduction mechanisms, and these structural properties need to be fully considered during the production process. -
Purification of IL-9R is relatively complex due to its transmembrane structure and complexity. Common purification methods include affinity chromatography, centrifugation, gel filtration and other technologies to obtain high purity IL-9R. -
The biological activity of IL-9R is verified by using methods such as cell culture, cell chemotactic assay, or enzym-linked immunosorbent assay, which can evaluate the binding capacity and signaling effect of IL-9R with its ligand, such as IL-9. -
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