Active Recombinant Human Interleukin 9 Receptor, His-tagged

• Cat.No.: IL9R-5664H
• Product Overview: RecombinantHuman IL9R protein was expressed in Murine myeloma cell line. Val40-Pro270,with a C-terminal 10-His tag.

Specification

• Cat. No.: IL9R-5664H
• Description: The specifichigh affinity functional IL9R complex consists of a ligand-specific IL9R (α) subunitand the common γ chain that is shared with the receptors for IL-2, IL-4, IL-7and IL-15. Both the IL9R subunit and the common γ chain are members of thehematopoietin receptor superfamily. The cDNAs encoding mouse and human IL-9receptors have been isolated. The deduced mouse and human transmembrane proteins,sharing 53% amino acid sequence identity, contain 468 and 533 amino acid residues,respectively. As a result of alternative splicing, cDNA clones encodingisoforms of IL9R, including a putative soluble form, have also been identified.
• Source: Mammalian cells
• Form: Lyophilized from a0.2 μm filtered solution in PBS and NaCl with BSA as a carrier protein.
• N-terminalSequence: Val40
• MolecularWeight: 27.4 kDa
• Activity: Measuredby its ability to inhibit the IL-9-dependent proliferation of MO7e human megakaryocyticleukemic cells. The ED50 for this effect is typically 1-4 μg/mL in thepresence of 5 ng/mL of rhIL-9.
• Endotoxin Level: <1.0EU per 1μg of the protein by the LAL method.
• SDS-PAGE: 38 kDa,reducing conditions.
• Purity: >95%,by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution: 250 μg/mLin sterile PBS containing at least 0.1% human or bovine serum albumin
• Storage: Use a manual defrost freezer and avoid repeated freeze-thawcycles. 12 months from date of receipt, -20 to -70°C as supplied. 1month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to-70°C under sterile conditions after reconstitution.
• Protein length: Val40-Pro270

Gene Information

• Gene Name: IL9R interleukin 9 receptor [ Homosapiens ]
• Official Symbol: IL9R
• Synonyms: IL9R; interleukin 9receptor; CD129;interleukin-9 receptor; IL-9R; IL-9 receptor; OTTHUMP00000024331;OTTHUMP00000024332
• Gene ID: 3581
• mRNA Refseq: NM_002186
• Protein Refseq: NP_002177
• MIM: 300007
• UniProt ID: Q01113
• Chromosome Location: Xq28 and Yq12
• Pathway: Cytokine-cytokine receptor interaction; Hematopoieticcell lineage; IL-9 Signaling Pathway; Jak-STAT signaling pathway
• Function: interleukin-9receptor activity; receptor activity

Reviews

05/10/2022

IL9R is very advanced and adopts the most environmentally friendly production process, which is worth vigorously promoting.

01/11/2022

The reproducibility of IL9R is very good, and the results are very consistent in each experiment or application, thanks to its high stability and reproducibility, which provides great convenience for follow-up studies.

02/27/2020

IL9R produced by them are widely used and suitable for various biological experiments.

Q&As

Can the treatment of cancer with IL9R improve the immune system of patients?

In pre-clinical trials, the IL9R significantly increased natural killer and CD4 + T cell levels in patients.

What somatic cell therapy-based data updates can recombinant IL9R be used for?

IL9R may play an important role in the treatment of central nervous system diseases and hematological diseases.

In which tumor therapies are recombinant IL9R most likely to be effective?

This needs to be further confirmed by large-scale clinical trials.

What techniques are used to study the relationship between IL9R and cancer?

This can be achieved through in vitro molecular cell techniques and carefully designed in vivo animal models.

Which diseases might be treated by recombinant IL9R?

There have been no large-scale clinical studies to prove which diseases the recombinant IL9R protein can treat.

Is the expression of IL9R in tumor cells correlated with patient prognosis?

Some studies have suggested that the expression of IL9R in tumor cells may be associated with patient prognosis.