IRAK2 involved in several pathways and played different roles in them. We selected most pathways IRAK2 participated on our site, such as Apoptosis, Neurotrophin signaling pathway, Tuberculosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRAK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name |
Pathway Related Protein |
| Apoptosis |
NGF; GZME; CTNNB2; DFFA; ATM; HMGB2; JUN; TNFRSF10B; BIRC2; BID |
| Neurotrophin signaling pathway |
CALM4; RPS6KA5; MAPK3; CAMK2B; RPS6KA2; PTPN11; AKT1; SHC1; PIK3R2; IKBKB |
| Tuberculosis |
FCGR1; IL23; IFNA17; TLR4; BID; MRC2; CALM3; CALML5; IL6; IFNB1 |
IRAK2 has several biochemical functions, for example, ATP binding, protein binding, protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IRAK2 itself. We selected most functions IRAK2 had, and list some proteins which have the same functions with IRAK2. You can find most of the proteins on our site.
| Function |
Related Protein |
| ATP binding |
GATB; MCM3; STK4; RAD51C; NARS; PRKCZ; AFG3L2; KIF9; TNK2B; SNRKB |
| protein binding |
WASH1; CHRM3; EVI5L; ZBTB44; PCBP1; EXOC3-AS1; INTS7; TRIM9; DMC1; PDGFRA |
| protein heterodimerization activity |
HIST1H4G; Bcl2a1b; UNC13A; SLC51A; DDX1; CENPW; NFYB; AGTR1A; ZFP423; SOX4 |
| protein homodimerization activity |
OXA1L; SLC11A1; IMPA1; GNPTG; HNF4A; MAOB; SYNDIG1; ABP1; CRTAM; DMBX1 |
| protein serine/threonine kinase activity |
SLC14A2; STK19; ALPK2; ZNF143B; PAK4; STK10; PAK1; SRPK1; CAMK1DA; MAST4 |
IRAK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRAK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRAK2.
TRAF6; IRAK1; TIRAP; IRAK3; k7_vaccc; ARAF; STT3A; TARDBP; ZC3H12A
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Rosenbaek, LL; Assentoft, M; et al. Characterization of a novel phosphorylation site in the sodium-chloride cotransporter, NCC. JOURNAL OF PHYSIOLOGY-LONDON 590:6121-6139(2012).
Ovsyannikova, I; Haralambieva, I; et al. The role of polymorphisms in Toll-like receptors and their associated intracellular signaling genes in measles vaccine immunity. HUMAN GENETICS 130:547-561(2011).
