IRAK2
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Official Full Name
interleukin-1 receptor-associated kinase 2
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Overview
Interleukin-1 (IL-1) receptor-associated kinase (IRAK) is a serine/threonine-specific kinase that can be coprecipitated in an IL-1-inducible manner with the IL-1 receptor. The mammalian family of IRAK molecules contains four members (IRAK1, IRAK2, IRAK3/I -
Synonyms
IRAK2; interleukin-1 receptor-associated kinase 2; interleukin-1 receptor-associated kinase-like 2; interleukin-1 receptor associated kinase-2; IRAK-2; MGC150550;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- E. coli
- E.coli
- HEK293
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Sf9 Insect Cell
- Wheat Germ
- C
- His
- GST
- Fc
- Avi
- Non
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | IRAK2-1417H | Active Recombinant Human IRAK2, GST-tagged | Sf9 Insect Cell | GST | Full length |
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| Human | IRAK2-332H | Recombinant Human IRAK2, GST-tagged, Active | Sf9 Insect Cell | GST |
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| Human | IRAK2-27503TH | Recombinant Human IRAK2 | Insect Cell | Non | 625 amino acids |
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| Human | IRAK2-7069H | Recombinant Human IRAK2 protein, His-tagged | E.coli | His | Val235~Ser521 |
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| Human | IRAK2-5171HCL | Recombinant Human IRAK2 293 Cell Lysate | HEK293 | Non |
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| Human | IRAK2-2997H | Recombinant Human IRAK2 Protein (Val235-Ser521), His tagged | E.coli | His | Val235-Ser521 |
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| Human | IRAK2-2753H | Recombinant Human IRAK2 protein, His-tagged | E.coli | His | 14-251 aa | |
| Human | IRAK2-5053H | Recombinant Human IRAK2 Protein, GST-tagged | Wheat Germ | GST |
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| Human | IRAK2-270H | Recombinant Human IRAK2 protein, His-tagged | E. coli | C-His | 1-625aa |
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| Human | IRAK2-301417H | Recombinant Human IRAK2 protein, GST-tagged | E.coli | GST | Asp14-Glu251 |
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| Human | IRAK2-5729HF | Recombinant Full Length Human IRAK2 Protein, GST-tagged | In Vitro Cell Free System | GST | 590 amino acids |
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| Human | IRAK2-7653H | Recombinant Human IRAK2 protein, His-tagged | E.coli | C-His | 1-625aa |
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| Mouse | Irak2-7070M | Recombinant Mouse Irak2 protein, His-tagged | E.coli | His | Asp209~Glu458 |
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| Mouse | IRAK2-8293M | Recombinant Mouse IRAK2 Protein | Mammalian Cell | His |
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| Mouse | IRAK2-4596M-B | Recombinant Mouse IRAK2 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Mouse | IRAK2-4596M | Recombinant Mouse IRAK2 Protein, His (Fc)-Avi-tagged | HEK293 | His&Fc&Avi |
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| Rat | Irak2-7071R | Recombinant Rat Irak2 protein, His-tagged | E.coli | His | Asp211~His458 (Accession # Q4QQS0) |
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| Rat | IRAK2-3094R | Recombinant Rat IRAK2 Protein | Mammalian Cell | His |
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| Rat | IRAK2-2750R | Recombinant Rat IRAK2 Protein, His (Fc)-Avi-tagged | HEK293 | His&Fc&Avi |
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| Rat | IRAK2-2750R-B | Recombinant Rat IRAK2 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Chicken | IRAK2-2317C | Recombinant Chicken IRAK2 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
IRAK2 involved in several pathways and played different roles in them. We selected most pathways IRAK2 participated on our site, such as Apoptosis, Neurotrophin signaling pathway, Tuberculosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRAK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Apoptosis | E2F1;Gzmg;BCL2;IRF4;NFKBIAB;CFLARA;DIABLOB;HRK;STK24A |
| Neurotrophin signaling pathway | MAPK1;RHOA;MAPK7;ARHGDIB;TRP53;BCL2;MAP2K1;CAMK2B;PRDM4 |
| Tuberculosis | HLA-DOA;HLA-DRB1;IFNA4;TGFB1;MAPK3;CALM3;IL1B;SPHK2;BCL2 |
IRAK2 has several biochemical functions, for example, ATP binding, protein binding, protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IRAK2 itself. We selected most functions IRAK2 had, and list some proteins which have the same functions with IRAK2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | UBE2B;WEE1;ACVR2AA;KIF1B;CSNK1G2B;DHX33;ACSBG2;ATP7A;ACTB2 |
| protein binding | CYTH2;E2F6;SKIV2L2;RIPPLY3;MYBL2;FAM115A;S100A2;C12orf5;SERPING1 |
| protein heterodimerization activity | HEXB;HER5;TAF6;THRA;ROPN1B;ALG2;SDCBP;TGFB3;CYBB |
| protein homodimerization activity | PCYT1A;HEXB;ADRB2;AOC3;KCNK3;TCF12;IRAK1;FAM109A;PKD2 |
| protein serine/threonine kinase activity | AKT3A;RPS6KA3B;BRAF;ARAF;PAK2A;NLK;MAP2K6;LRRK1;CAMK2B1 |
IRAK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRAK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRAK2.
TRAF6; IRAK1; TIRAP; IRAK3; k7_vaccc; ARAF; STT3A; TARDBP; ZC3H12A
Research Area
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Customer Reviews (3)
Write a reviewTrusting in its consistent results, I am able to embark on my research with assurance and optimism.
Its unwavering stability and functionality have significantly contributed to the success and validity of my experimental outcomes.
I am profoundly impressed by the technical support rendered by the manufacturer.
Q&As (5)
Ask a questionYes, there are ongoing clinical trials exploring IRAK2 inhibitors as potential treatments for autoimmune diseases and other conditions.
Currently, there are no widely available diagnostic tests specifically for IRAK2-related conditions. Diagnosis often relies on clinical symptoms and other tests.
IRAK2 is a key player in the inflammatory signaling pathway, which can lead to the production of pro-inflammatory cytokines.
Gene mutations in IRAK2 can disrupt the normal immune response, leading to susceptibility to infections and autoimmune diseases.
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