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  • Official Full Name

    interleukin-1 receptor-associated kinase 2

  • Overview

    Interleukin-1 (IL-1) receptor-associated kinase (IRAK) is a serine/threonine-specific kinase that can be coprecipitated in an IL-1-inducible manner with the IL-1 receptor. The mammalian family of IRAK molecules contains four members (IRAK1, IRAK2, IRAK3/I
  • Synonyms

    IRAK2; interleukin-1 receptor-associated kinase 2; interleukin-1 receptor-associated kinase-like 2; interleukin-1 receptor associated kinase-2; IRAK-2; MGC150550;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IRAK2-1417H Active Recombinant Human IRAK2, GST-tagged Sf9 Insect Cell GST Full length
Human IRAK2-332H Recombinant Human IRAK2, GST-tagged, Active Sf9 Insect Cell GST
Human IRAK2-27503TH Recombinant Human IRAK2 Insect Cell N/A 625 amino acids
Human IRAK2-7069H Recombinant Human IRAK2 protein, His-tagged E.coli His Val235~Ser521
Human IRAK2-5171HCL Recombinant Human IRAK2 293 Cell Lysate HEK293 N/A
Human IRAK2-2997H Recombinant Human IRAK2 Protein (Val235-Ser521), His tagged E.coli His Val235-Ser521
Human IRAK2-2753H Recombinant Human IRAK2 protein, His-tagged E.coli His 14-251 aa
Human IRAK2-5053H Recombinant Human IRAK2 Protein, GST-tagged Wheat Germ GST
Human IRAK2-301417H Recombinant Human IRAK2 protein, GST-tagged E.coli GST Asp14-Glu251
Human IRAK2-5729HF Recombinant Full Length Human IRAK2 Protein, GST-tagged In Vitro Cell Free System GST 590 amino acids
Mouse Irak2-7070M Recombinant Mouse Irak2 protein, His-tagged E.coli His Asp209~Glu458
Mouse IRAK2-8293M Recombinant Mouse IRAK2 Protein Mammalian Cell His
Mouse IRAK2-4596M-B Recombinant Mouse IRAK2 Protein Pre-coupled Magnetic Beads HEK293
Mouse IRAK2-4596M Recombinant Mouse IRAK2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Irak2-7071R Recombinant Rat Irak2 protein, His-tagged E.coli His Asp211~His458 (Accession # Q4QQS0)
Rat IRAK2-3094R Recombinant Rat IRAK2 Protein Mammalian Cell His
Rat IRAK2-2750R Recombinant Rat IRAK2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat IRAK2-2750R-B Recombinant Rat IRAK2 Protein Pre-coupled Magnetic Beads HEK293
Chicken IRAK2-2317C Recombinant Chicken IRAK2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • IRAK2 Related Articles
  • IRAK2 Related Research Area

IRAK2 involved in several pathways and played different roles in them. We selected most pathways IRAK2 participated on our site, such as Apoptosis, Neurotrophin signaling pathway, Tuberculosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRAK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Neurotrophin signaling pathwayMAPK13;SH2B3;MAP2K1;NFKBIE;RAP1B;AKT1;MAPK3;GSK3B;PRKCD

IRAK2 has several biochemical functions, for example, ATP binding, protein binding, protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IRAK2 itself. We selected most functions IRAK2 had, and list some proteins which have the same functions with IRAK2. You can find most of the proteins on our site.

Function Related Protein
protein heterodimerization activityTXLNG;NTSR1;BMP2B;SNX2;SRI;SNX1;TTR;CLNS1A;CREB3L3
protein homodimerization activityNR4A2;HSD17B4;ZHX3;XBP1;GSTM4;RNF40;GSTM7;GM5506;OXA1L
protein serine/threonine kinase activityRPS6KA2;MAPK8;PLK2B;NEK8;PHKG2;SMOK3A;CLK2;ROCK2A;GAK

IRAK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRAK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRAK2.


Furi, I; Sipos, F; et al. Association of Self-DNA Mediated TLR9-Related Gene, DNA Methyltransferase, and Cytokeratin Protein Expression Alterations in HT29-Cells to DNA Fragment Length and Methylation Status. SCIENTIFIC WORLD JOURNAL :-(2013).
Rosenbaek, LL; Assentoft, M; et al. Characterization of a novel phosphorylation site in the sodium-chloride cotransporter, NCC. JOURNAL OF PHYSIOLOGY-LONDON 590:6121-6139(2012).
Ovsyannikova, I; Haralambieva, I; et al. The role of polymorphisms in Toll-like receptors and their associated intracellular signaling genes in measles vaccine immunity. HUMAN GENETICS 130:547-561(2011).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Are there any clinical trials targeting IRAK2? 03/07/2022

Yes, there are ongoing clinical trials exploring IRAK2 inhibitors as potential treatments for autoimmune diseases and other conditions.

Is there a diagnostic test for IRAK2-related conditions? 08/28/2021

Currently, there are no widely available diagnostic tests specifically for IRAK2-related conditions. Diagnosis often relies on clinical symptoms and other tests.

How is IRAK2 involved in inflammatory responses? 10/07/2016

IRAK2 is a key player in the inflammatory signaling pathway, which can lead to the production of pro-inflammatory cytokines.

Are there any cancer treatments targeting IRAK2? 07/10/2016

How can gene mutations in IRAK2 affect human health? 04/26/2016

Gene mutations in IRAK2 can disrupt the normal immune response, leading to susceptibility to infections and autoimmune diseases.

Customer Reviews (3)

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    Trusting in its consistent results, I am able to embark on my research with assurance and optimism.


      Its unwavering stability and functionality have significantly contributed to the success and validity of my experimental outcomes.


        I am profoundly impressed by the technical support rendered by the manufacturer.

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