Recombinant Human IRAK2 Protein, GST-tagged

• Cat.No.: IRAK2-5053H
• Product Overview: Human IRAK2 full-length ORF (BAG35695.1, 1 a.a. - 590 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB. [provided by RefSeq
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 91.7 kDa
• AA Sequence: MACYIYQLPSWVLDDLCRNMDALSE WDWMEFASYVITDLTQLRKIKSMER VQGVSITRELLWWWGMRQATVQQLV DLLCRLELYRAAQIILNWKPAPEIR CPIPAFPDSVKPEKPLAASVRKAED EQEEGQPVRMATFPGPGSSPARAHQ PAFLQPPEEDAPHSLRSDLPTSSDS KDFSTSIPKQEKLLSLAGDSLFWSE ADVVQATDDFNQNRKISQGTFADVY RGHRHGKPFVFKKLRETACSSPGSI ERFFQAELQICLRCCHPNVLPVLGF CAARQFHSFIYPYMANGSLQDRLQG QGGSDPLPWPQRVSICSGLLCAVEY LHGLEIIHSNVKSSNVLLDQNLTPK LAHPMAHLCPVNKRSKYTMMKTHLL RTSAAYLPEDFIRVGQVTKRVDIFS CGIVLAEVLTGIPAMDNNRSPVYLK DLLLSEIPSSTASLCSRKTGVENVM AKEICQKYLEKGAGRLPEDCAEALA TAACLCLRRRNTSLQEVCGSVAAVE ERLRGRETLLPWSGLSEGTGSSSNT PEETDDVDNSSLDASSSMSVAPWAG AATPLLPTENGEGRLRVIVGREADS SSEACVGLEPPQDVT
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: IRAK2 interleukin-1 receptor-associated kinase 2 [ Homo sapiens ]
• Official Symbol: IRAK2
• Synonyms: IRAK2; interleukin-1 receptor-associated kinase 2; interleukin-1 receptor-associated kinase-like 2; interleukin-1 receptor associated kinase-2; IRAK-2; MGC150550
• Gene ID: 3656
• mRNA Refseq: NM_001570
• Protein Refseq: NP_001561
• MIM: 603304
• UniProt ID: O43187

Reviews

11/23/2021

Trusting in its consistent results, I am able to embark on my research with assurance and optimism.

08/22/2018

Its unwavering stability and functionality have significantly contributed to the success and validity of my experimental outcomes.

10/22/2016

I am profoundly impressed by the technical support rendered by the manufacturer.

Q&As

Are there any clinical trials targeting IRAK2?

Yes, there are ongoing clinical trials exploring IRAK2 inhibitors as potential treatments for autoimmune diseases and other conditions.

Is there a diagnostic test for IRAK2-related conditions?

Currently, there are no widely available diagnostic tests specifically for IRAK2-related conditions. Diagnosis often relies on clinical symptoms and other tests.

How is IRAK2 involved in inflammatory responses?

IRAK2 is a key player in the inflammatory signaling pathway, which can lead to the production of pro-inflammatory cytokines.

Are there any cancer treatments targeting IRAK2?

How can gene mutations in IRAK2 affect human health?

Gene mutations in IRAK2 can disrupt the normal immune response, leading to susceptibility to infections and autoimmune diseases.