Recombinant Human IRAK2, GST-tagged, Active

• Cat.No.: IRAK2-332H
• Product Overview: Recombinant full-length human IRAK2 was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW = 103 kDa.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Description: Interleukin-1 receptor-associated kinase 2 (IRAK2) is important downstream signaling components of Toll-like receptors (TLRs). IRAKs were first described as signal transducers for IL-1 and later have been implicated in signal transduction of other members of the Toll/IL-1 receptor family. The interleukin-1 receptor (IL-1R) signaling pathway leads to NFκB activation in mammals. To date, four mammalian IRAKs have been identified (IRAK-1, IRAK-2, IRAK-4, and IRAK-M). It is believed that IRAK-2 could be an additional therapeutic target for inhibiting IL-1-induced inflammation.
• Sequence: Full-length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: IRAK2 interleukin-1 receptor-associated kinase 2 [ Homo sapiens ]
• Synonyms: IRAK2; interleukin-1 receptor-associated kinase 2; IRAK-2; MGC150550;interleukin-1 receptor associated kinase-2; Interleukin-1 receptor-associated kinase-like 2
• Gene ID: 3656
• mRNA Refseq: NM_001570
• Protein Refseq: NP_001561
• MIM: 603304
• UniProt ID: O43187
• Chromosome Location: 3p25.3
• Pathway: Apoptosis; Neurotrophin signaling pathway
• Function: ATP binding; NF-kappaB-inducing kinase activity; protein heterodimerization activity; protein homodimerization activity; protein kinase activity