Recombinant Human IRAK2, GST-tagged, Active IRAK2-332H

Recombinant Human IRAK2, GST-tagged, Active


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Cat.No. : IRAK2-332H Optional Service: Optional requirements on this protein
Product Overview : Recombinant full-length human IRAK2 was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW = 103 kDa.
Description : Interleukin-1 receptor-associated kinase 2 (IRAK2) is important downstream signaling components of Toll-like receptors (TLRs). IRAKs were first described as signal transducers for IL-1 and later have been implicated in signal transduction of other members of the Toll/IL-1 receptor family. The interleukin-1 receptor (IL-1R) signaling pathway leads to NFκB activation in mammals. To date, four mammalian IRAKs have been identified (IRAK-1, IRAK-2, IRAK-4, and IRAK-M). It is believed that IRAK-2 could be an additional therapeutic target for inhibiting IL-1-induced inflammation.
Source : Sf9 insect cells using baculovirus.
Sequence : Full-length.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : IRAK2 interleukin-1 receptor-associated kinase 2 [ Homo sapiens ]
Synonyms : IRAK2; interleukin-1 receptor-associated kinase 2; IRAK-2; MGC150550;interleukin-1 receptor associated kinase-2; Interleukin-1 receptor-associated kinase-like 2
Gene ID : 3656
mRNA Refseq : NM_001570
Protein Refseq : NP_001561
MIM : 603304
UniProt ID : O43187
Chromosome Location : 3p25.3
Pathway : Apoptosis; Neurotrophin signaling pathway
Function : ATP binding; NF-kappaB-inducing kinase activity; protein heterodimerization activity; protein homodimerization activity; protein kinase activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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