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Official Full Name interferon regulatory factor 1
Background IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppressoion. [provided by RefSeq, Jul 2008]
Synonyms IRF1; interferon regulatory factor 1; MAR; IRF-1; interferon regulatory factor 1 isoform d78;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • C-Myc/DDK
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IRF1-128H Recombinant Human IRF1 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human IRF1-243H Recombinant Human IRF1 Mammalian Cell His
    Human IRF1-25H Recombinant Human interferon regulatory factor 1, His-tagged E.coli His
    Human IRF1-29246TH Recombinant Human IRF1, His-tagged E.coli His
    Human IRF1-314H Recombinant Human IRF1 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Human IRF1-5046H Recombinant Human IRF1 Protein, GST-tagged Wheat Germ GST
    Human IRF1-5168HCL Recombinant Human IRF1 293 Cell Lysate HEK293 N/A
    Mouse Irf1-3572M Recombinant Mouse Irf1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse Irf1-7123M Recombinant Mouse Irf1 protein, His & GST-tagged E.coli His/GST
    Rat IRF1-3096R Recombinant Rat IRF1 Protein Mammalian Cell His
    Rhesus Macaque IRF1-2293R Recombinant Rhesus monkey IRF1 Protein, His-tagged Mammalian Cell His
    Chicken IRF1-6966C Recombinant Chicken IRF1 Mammalian Cell His

    irf1 involved in several pathways and played different roles in them. We selected most pathways irf1 participated on our site, such as Prolactin signaling pathway, Pertussis, Hepatitis C, which may be useful for your reference. Also, other proteins which involved in the same pathway with irf1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Prolactin signaling pathway TNFRSF11A; SHC2; SOCS3; PIK3CG; TNFSF11; PIK3R5; SHC1; PIK3R2; GALT; MAPK12
    Pertussis CXCL5; ITGB1; GNAI1; C1QB; CALM2; MAPK3; ITGA5; MAPK12; CALM1; C3
    Hepatitis C CD81; MAVS; DDX58; IFNA4; IFNA1; PIK3R3; TLR3; NRAS; SCARB1; CLDN16

    irf1 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by irf1 itself. We selected most functions irf1 had, and list some proteins which have the same functions with irf1. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding H1M; HDGF2; LCOR; CDX1A; NFIL3; HIST1H4J; EME1; PAX4; HER12; MIS18BP1
    RNA polymerase II core promoter proximal region sequence-specific DNA binding ZNF148; TFE3B; ELK3; HOXA10; RBPJB; PLAG1; MYC; POU4F3; MEF2B; MEF2A
    protein binding MAGEE1; DLA; PLN; PENK; VENTX; ARNTL; NOP10; SH3GL1; PPP1R16A; MSH4
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding FOS; WT1; NR5A2; POU3F2; TBX20; NR1H4; TTC6; RBPJ; ATF2; NEUROD1

    irf1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with irf1 here. Most of them are supplied by our site. Hope this information will be useful for your research of irf1.

    E7; 51094465; ULK2; E7; CDKN1B; QARS; foxp3_human_gene; ifnl1_human_gene

    Maruyama, S; Kanoh, M; et al. A novel function of interferon regulatory factor-1: inhibition of T(h)2 cells by down-regulating the Il4 gene during Listeria infection. INTERNATIONAL IMMUNOLOGY 27:143-152(2015).
    Bake, V; Roesler, S; et al. Synergistic interaction of Smac mimetic and IFN alpha to trigger apoptosis in acute myeloid leukemia cells. CANCER LETTERS 355:224-231(2014).

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