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IRF1

  • Official Full Name

    interferon regulatory factor 1

  • Overview

    IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppressoion. [provided by RefSeq, Jul 2008]
  • Synonyms

    IRF1; interferon regulatory factor 1; MAR; IRF-1; interferon regulatory factor 1 isoform d78;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Mamanlian cells
  • Mammalian Cell
  • Wheat Germ
  • C
  • Myc
  • DDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • HA
  • Myc|DDK
  • N/A
  • N
  • SUMO
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IRF1-243H Recombinant Human IRF1 Mammalian Cell His
Human IRF1-25H Recombinant Human interferon regulatory factor 1, His-tagged E.coli His
Human IRF1-29246TH Recombinant Human IRF1, His-tagged E.coli His
Human IRF1-128H Recombinant Human IRF1 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human IRF1-5168HCL Recombinant Human IRF1 293 Cell Lysate HEK293 N/A
Human IRF1-5046H Recombinant Human IRF1 Protein, GST-tagged Wheat Germ GST
Human IRF1-314H Recombinant Human IRF1 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human IRF1-4332H Recombinant Human IRF1 protein, His&GST-tagged Insect Cell His/GST 1-325aa
Human IRF1-3114H Recombinant Human IRF1 protein, His-HA-tagged E.coli His-HA 1-325aa
Human IRF1-5735HF Recombinant Full Length Human IRF1 Protein, GST-tagged In Vitro Cell Free System GST 325 amino acids
Human IRF1-1133H Recombinant Human IRF1 protein, His&Myc-tagged E.coli His&Myc 1-325aa(C83S)
Human IRF1-1487H Recombinant Human IRF1 protein, His&Myc-tagged E.coli His&Myc 1-325aa(K29R)
Human IRF1-7512HFL Recombinant Full Length Human IRF1 protein, Flag-tagged Mamanlian cells Flag
Human IRF1-3169H Recombinant Human IRF1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human IRF1-5852H Recombinant Human IRF1 protein, His&Myc-tagged Insect Cell His&Myc 1-325aa(C83S)
Human IRF1-3169H-B Recombinant Human IRF1 Protein Pre-coupled Magnetic Beads HEK293
Human IRF1-3118H Recombinant Human IRF1 Protein (Trp11-Glu276), N-His tagged E.coli N-His Trp11-Glu276
Mouse Irf1-7123M Recombinant Mouse Irf1 protein, His & GST-tagged E.coli His/GST His44~Pro319 (Accession # P15314)
Mouse Irf1-3572M Recombinant Mouse Irf1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat IRF1-3096R Recombinant Rat IRF1 Protein Mammalian Cell His
Rat Irf1-1063R Recombinant Rat Irf1 Protein, His&SUMO-tagged E.coli N-His&SUMO Pro145-Pro328
Rat IRF1-2752R-B Recombinant Rat IRF1 Protein Pre-coupled Magnetic Beads HEK293
Rat IRF1-2752R Recombinant Rat IRF1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque IRF1-2293R Recombinant Rhesus monkey IRF1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque IRF1-2114R Recombinant Rhesus Macaque IRF1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque IRF1-2114R-B Recombinant Rhesus Macaque IRF1 Protein Pre-coupled Magnetic Beads HEK293
Chicken IRF1-6966C Recombinant Chicken IRF1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • IRF1 Related Articles
  • IRF1 Related Research Area

IRF1 involved in several pathways and played different roles in them. We selected most pathways IRF1 participated on our site, such as Prolactin signaling pathway, Pertussis, Hepatitis C, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Prolactin signaling pathwayMAP2K2;SOCS1;CCND2;MAPK10;TNFRSF11A;MAPK8;FOS;INS1;SHC4
PertussisTNF;C1R;RELA;CALML5;IL-8;AMCF-II;CALM1;TICAM2;C1S
Hepatitis CPIK3R1;AKT2;NFKB1;PIAS1;CLDN8;IFNA2;IFNA14;OAS1;PIK3R2

IRF1 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRF1 itself. We selected most functions IRF1 had, and list some proteins which have the same functions with IRF1. You can find most of the proteins on our site.

Function Related Protein
DNA bindingNUFIP1;POLA1;MYCLA;ZFAND5;ZNF785;BLZF1;DLX4B;FOXN1;PCBP3
RNA polymerase II core promoter proximal region sequence-specific DNA bindingCC2D1A;FOXA2;TTC6;ASCL2;BCL11A;SMAD6;ZNF680;TFE3B;RFX1
protein bindingCCER1;RPS11;STEAP3;UACA;MED22;GNGT1;SRF;MRPL11;RAB25
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingNR4A2;NRF1;NFIB;NFATC2;EPAS1;HEYL;CREB1;SMAD2;BARHL2

IRF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRF1.

E7; 51094465; ULK2; E7; CDKN1B; QARS; foxp3_human_gene; ifnl1_human_gene

Maruyama, S; Kanoh, M; et al. A novel function of interferon regulatory factor-1: inhibition of T(h)2 cells by down-regulating the Il4 gene during Listeria infection. INTERNATIONAL IMMUNOLOGY 27:143-152(2015).
Bake, V; Roesler, S; et al. Synergistic interaction of Smac mimetic and IFN alpha to trigger apoptosis in acute myeloid leukemia cells. CANCER LETTERS 355:224-231(2014).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
How do changes in IRF1 expression or function affect responses to bacterial infections? 06/19/2022

Variations in IRF1 impact the body's response to bacterial infections.

How does IRF1 impact the pathogenesis of autoimmune diseases? 08/01/2021

IRF1 may play a key role in the development of autoimmune diseases.

What role does IRF1 play in antiviral defense mechanisms? 02/09/2021

IRF1 is crucial in antiviral defenses, enhancing response to viral infections.

How does IRF1 regulate gene expression in the immune response? 12/13/2020

IRF1 activates immune response genes, especially interferon-responsive genes.

What is the effect of IRF1 on tumor suppression and cancer cell proliferation? 07/01/2019

IRF1 acts as a tumor suppressor, inhibiting cancer cell growth.

How does IRF1 influence the development and function of T cells and NK cells? 04/09/2018

IRF1 affects the development and function of T cells and NK cells.

How does IRF1 modulate inflammatory responses and cytokine production? 03/27/2018

IRF1 regulates inflammation and cytokine production.

Customer Reviews (3)

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Reviews
10/19/2021

    Swift protein expression optimization, boosts our research productivity.

    05/03/2020

      Accurate protein structural characterization, a cornerstone of our studies.

      11/01/2019

        High-quality protein sequencing, invaluable for our scientific work.

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