Recombinant Human interferon regulatory factor 1, His-tagged

• Cat.No.: IRF1-25H
• Product Overview: Recombinant Human Interferon Regulatory Factor-1 produced inE.Coliis a single, non-glycosylated, polypeptide chain containing 134 amino acids (1-114) with a His Tag of 20 aa, and having a molecular mass of 15 kDa. The IRF-1 is purified by proprietary chromatographic techniques.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: IRF1, Interferon regulatory factor 1, is a member of the interferon regulatory transcription factor (IRF) family which regulates gene expression critical to immune response, hematopoiesis and proliferation. IRF-1 is a transcriptional activator for IFN-A, IFN-B, and IFN-G stimulated genes. IRF1 is also a tumor suppressor transcription factor inducing apoptosis of tumorigenic cell lines.
• Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MPITRMRMRP WLEMQINSNQ IPGLIWINKE EMIFQIPWKHAAKHGWDINK DACLFRSWAI HTGRYKAGEK EPDPKTWKAN FRCAMNSLPD IEEVKDQSRN KGSSAVRVYR MLPP
• Physical Appearance: Sterile Filtered colorless solution.
• Purity: Greater than 90.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
• Formulation: 1 mg/ml in 20mM Tris pH-8 and 10% glycerol.
• Storage: Liquid Interferon although stable at 10°Cfor 1 week, should be stored below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Gene Information

• Gene Name: IRF1 interferon regulatory factor 1 [ Homo sapiens ]
• Synonyms: IRF1; interferon regulatory factor 1; MAR; IRF-1; OTTHUMP00000198266; interferon regulatory factor-1
• Gene ID: 3659
• mRNA Refseq: NM_002198
• Protein Refseq: NP_002189
• MIM: 147575
• UniProt ID: P10914
• Chromosome Location: 5q23-q31
• Function: sequence-specific DNA binding; transcription factor activity