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IRF3

  • Official Full Name

    interferon regulatory factor 3

  • Overview

    This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
  • Synonyms

    IRF3; interferon regulatory factor 3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • His|Myc
  • His|SUMO
  • His|T7
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IRF3-61H Recombinant Human IRF3 protein, His/T7-tagged E.coli His/T7 Met1~Lys360
Human IRF3-27H Recombinant Human Interferon Regulatory Factor 3 E.coli N/A
Human IRF3-62H Recombinant Human IRF3 protein, His/sumo-tagged E.coli His/SUMO 1-452 aa
Human IRF3-60H Recombinant Human IRF3 protein, His-tagged E.coli His 442aa(including fusion tag)
Human IRF3-5166HCL Recombinant Human IRF3 293 Cell Lysate HEK293 N/A
Human IRF3-4151H Recombinant Human IRF3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human IRF3-013H Recombinant Human IRF3 Protein, His-tagged E.coli His 1-427
Human IRF3-5041H Recombinant Human IRF3 Protein, GST-tagged Wheat Germ GST
Human IRF3-497HFL Recombinant Full Length Human IRF3 Protein, C-Flag-tagged Mammalian cells Flag
Human IRF3-072H Recombinant Human IRF3 Protein, His-tagged E. coli His 1-427
Human IRF3-5738HF Recombinant Full Length Human IRF3 Protein, GST-tagged In Vitro Cell Free System GST 452 amino acids
Human IRF3-1196H Recombinant Human IRF3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human IRF3-1196H-B Recombinant Human IRF3 Protein Pre-coupled Magnetic Beads HEK293
Human IRF3-2892H Recombinant Human IRF3 Protein (Met1-Ser123), N-His tagged E.coli N-His Met1-Ser123
Mouse Irf3-7149M Recombinant Mouse Irf3 protein, His & T7-tagged E.coli His/T7 Met1~Asp406 (Accession # P70671)
Mouse IRF3-8301M Recombinant Mouse IRF3 Protein Mammalian Cell His
Mouse IRF3-2146M Recombinant Mouse IRF3 Protein (1-419 aa), His-Myc-tagged Yeast His/Myc 1-419 aa
Mouse Irf3-3574M Recombinant Mouse Irf3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse IRF3-4603M Recombinant Mouse IRF3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse IRF3-4603M-B Recombinant Mouse IRF3 Protein Pre-coupled Magnetic Beads HEK293
Mouse Irf3-3115M Recombinant Mouse Irf3 protein, His&Myc-tagged E.coli His&Myc 1-419aa
Rhesus Macaque IRF3-2297R Recombinant Rhesus monkey IRF3 Protein, His-tagged Mammalian Cell His
Rhesus Macaque IRF3-2118R-B Recombinant Rhesus Macaque IRF3 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque IRF3-2118R Recombinant Rhesus Macaque IRF3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish IRF3-7262Z Recombinant Zebrafish IRF3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • IRF3 Related Articles
  • IRF3 Related Gene Family
  • IRF3 Related Research Area

IRF3 involved in several pathways and played different roles in them. We selected most pathways IRF3 participated on our site, such as Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Cytosolic DNA-sensing pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRF3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Toll-like receptor signaling pathwayAKT2;LY96;CD86;TBK1;MAP3K7;PIK3CG;MAPK8A;CCL4L2;TLR5
RIG-I-like receptor signaling pathwayMAP3K1;CXCL10;MAPK9;IL12B;IFNA16;OTUD5A;IFNA13;IL8L2;TNF
Cytosolic DNA-sensing pathwayIKBKB;NFKB1;IL1B;POLR2EB;IFNPHI3;IFNA10;NFKBIB;POLR3D;IL6
PertussisC4BPB;IRF1;GNAI1;MAPK12;RHOA;SERPING1;CFL2;IRAK4;C4BP
Hepatitis CPIAS1;PIK3R1;CLDN5;ARAF;OAS1A;GRB2;IFNA21;SOCS3;Ifna15
Hepatitis BMAPK8;DDB2;CXCL8;CCNE1;STAT3;PRKCB;IFNA1;CCNA1;NFATC3
MeaslesHSPA1B;Ifna11;TBK1;CD3E;TLR7;TLR4;PIK3CB;Il2;TP53
Influenza AIFNAR2;TMPRSS2;IFIH1;PRKCA;PIK3R2;PRKCB;HLA-DRB3;TNFRSF10B;HLA-DRB5
Herpes simplex infectionCUL1A;SKP1;OAS3;EIF2AK3;CDC34A;IFNA17;EIF2AK2;TRAF3;HLA-DQB1
Epstein-Barr virus infectionPIK3R1;CD19;POLR2C;EIF2AK1;YWHAZ;PSMD4;BCL2;AKT2;TRAF6
Viral carcinogenesisIL6ST;TBPL2;KRAS;TRP53;BAD;RHOA;YWHAE;HIST1H4N;PXN

IRF3 has several biochemical functions, for example, DNA binding, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRF3 itself. We selected most functions IRF3 had, and list some proteins which have the same functions with IRF3. You can find most of the proteins on our site.

Function Related Protein
DNA bindingTSN;ZNF684;RAG1;ZNF37A;CROP;TRNP1;TIGD5;DNMT3A;ZBTB26
identical protein bindingTGFB3;GLUD1;ROBO2;JMJD6;ALCAMA;PPP1R13L;SNX33;APOH;ORAI1
protein bindingCRIPT;TRAM1;NUP107;PTPN11A;RNF7;EIF4A1;SRMS;DDB1;TRIM69
protein homodimerization activityIRAK3;KCNE2;KCNH2;BAK1;ANXA6;ACTN3;PLEKHB1;ENO2;HELT
regulatory region DNA bindingIRF8;IRF3;IRF4A;HMGA2;IRF1B;NFKB1;IRF1A;IRF5;IRF6
transcription cofactor activityMXD1;LDB1B;MED1;NFE2L1;MED16;ELK4;LDB2B;TRIP13;TFB2M
transcription factor activity, sequence-specific DNA bindingRARGB;HES1;HLFA;ZNF287;TBX22;ZNF544;SP3A;CEBPA;TFDP1A

IRF3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRF3 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRF3.

TBK1; CREBBP

Wang, J; Vodovotz, Y; et al. Injury-induced MRP8/MRP14 stimulates IP-10/CXCL10 in monocytes/macrophages. FASEB JOURNAL 29:250-262(2015).
Thackray, LB; Shrestha, B; et al. Interferon Regulatory Factor 5-Dependent Immune Responses in the Draining Lymph Node Protect against West Nile Virus Infection. JOURNAL OF VIROLOGY 88:11007-11021(2014).
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