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Official Full Name interferon regulatory factor 3
Background This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Synonyms IRF3; interferon regulatory factor 3;
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • GST
    • His
    • Myc
    • SUMO
    • T7
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IRF3-072H Recombinant Human IRF3 Protein, His-tagged E. coli His
    Human IRF3-013H Recombinant Human IRF3 Protein, His-tagged E.coli His
    Human IRF3-27H Recombinant Human Interferon Regulatory Factor 3 E.coli N/A
    Human IRF3-4151H Recombinant Human IRF3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human IRF3-5041H Recombinant Human IRF3 Protein, GST-tagged Wheat Germ GST
    Human IRF3-5166HCL Recombinant Human IRF3 293 Cell Lysate HEK293 N/A
    Human IRF3-60H Recombinant Human IRF3 protein, His-tagged E.coli His
    Human IRF3-61H Recombinant Human IRF3 protein, His/T7-tagged E.coli His/T7
    Human IRF3-62H Recombinant Human IRF3 protein, His/sumo-tagged E.coli His/SUMO
    Mouse IRF3-2146M Recombinant Mouse IRF3 Protein (1-419 aa), His-Myc-tagged Yeast His/Myc
    Mouse Irf3-3574M Recombinant Mouse Irf3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse Irf3-7149M Recombinant Mouse Irf3 protein, His & T7-tagged E.coli His/T7
    Mouse IRF3-8301M Recombinant Mouse IRF3 Protein Mammalian Cell His
    Rhesus Macaque IRF3-2297R Recombinant Rhesus monkey IRF3 Protein, His-tagged Mammalian Cell His
    Zebrafish IRF3-7262Z Recombinant Zebrafish IRF3 Mammalian Cell His

    irf3 involved in several pathways and played different roles in them. We selected most pathways irf3 participated on our site, such as Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Cytosolic DNA-sensing pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with irf3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Toll-like receptor signaling pathway IL12B; IFNA6; IFNPHI1; MAP2K4; LY96; TRAF6; IL-8; PIK3R3A; IFNA14; IFNA12
    RIG-I-like receptor signaling pathway IFNPHI1; IKBKE; DAK; MAPK14A; MAPK8A; IFNA13; MAPK9; IFNK; DDX58; TP-1
    Cytosolic DNA-sensing pathway MAVS; POLR3C; NFKBIA; CCL5; RIPK3; POLR3H; ZBP1; POLR2K; IFNA14; PYCARD
    Pertussis SERPING1; IL1A; C4BPA; AMCF-II; C1S; CFL2; CALM2; CASP1; MAPK10; Il23a
    Hepatitis C EIF2AK4; CD81; SOS1; Ifna11; GRB2; CLDN4; BAD; IRF9; CLDN23; AKT2
    Measles IL13; PIK3CD; IL4; IFNA16; NFKBIB; IFNA1; STAT5B; BBC3; IRF3; RELA
    Influenza A IL1A; PIK3R3; HLA-DRB1; TNFSF10; HLA-DRB3; HSPA1L; PIK3R5; PRSS1; EIF2AK3; IFNA4
    Herpes simplex infection PVRL2; IRF3; SRPK1A; C3A.2; MYD88; TNFRSF1A; PVRL1B; HLA-DRB5; SRSF7; TRAF1
    Epstein-Barr virus infection PIK3R3; TRP53; ICAM1; HSPA1B; TRAF6; MDM2; HLA-B; TBPL1; EP300; FGR
    Viral carcinogenesis Casp3; HDAC8; TRAF5; TRAF1; HLA-C; ACTN2; PRKACB; CCND1; HLA-F; HIST1H2BJ

    irf3 has several biochemical functions, for example, DNA binding, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by irf3 itself. We selected most functions irf3 had, and list some proteins which have the same functions with irf3. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding TFCP2; ENG1A; ZFP64; IRX6A; ZBTB12; TET3; TERT; DRGX; H1M; ESRRA
    identical protein binding ATXN10; FAS; SMURF2; TRADD; MICU1; TPCN2; KCNH2; DYNLT1F; CEACAM16; CCDC155
    protein binding JAKMIP2; NOL12; HCFC1; ADAMTS5; VPS72; HTR6; MTAP; FANCC; FURIN; SSX1
    protein homodimerization activity DNM1L; RAB11FIP4A; TP53I3; MFF; CADM1B; AOC3; TYR; ABCG2; Trl; ATPIF1B
    regulatory region DNA binding HMGA2; IRF3; IRF8; IRF2A; IRF1A; IRF1B; IRF6; IRF4A; NFKB1; IRF5
    transcription cofactor activity MED1; SLC26A3; LDB1B; LDB2; ZNF710; ZFP710; MAX; NFE2L1; TAF13; HES6
    transcription factor activity, sequence-specific DNA binding ZNF567; ELK1; HOXB5A; IRF9; TEAD1A; FOXI3A; HSFX1; SREBF1; GLI3; ZEB1

    irf3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with irf3 here. Most of them are supplied by our site. Hope this information will be useful for your research of irf3.


    Wang, J; Vodovotz, Y; et al. Injury-induced MRP8/MRP14 stimulates IP-10/CXCL10 in monocytes/macrophages. FASEB JOURNAL 29:250-262(2015).
    Thackray, LB; Shrestha, B; et al. Interferon Regulatory Factor 5-Dependent Immune Responses in the Draining Lymph Node Protect against West Nile Virus Infection. JOURNAL OF VIROLOGY 88:11007-11021(2014).

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