ITGB1

  • Official Full Name

    integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)

  • Overview

    Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene.
  • Synonyms

    CD29; FNRB; MDF2; VLAB; GPIIA; MSK12; VLA-BETA; integrin beta-1 (avian); ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Others
  • Protein Pre-coupled Magnetic Beads
  • Bos taurus (Bovine)
  • Camelus bactrianus (Bactrian camel)
  • Chicken
  • Felis catus (Cat) (Felis silvestris catus)
  • Gallus gallus (Chicken)
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Ovis aries (Sheep)
  • Pig
  • Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
  • Rat
  • Rattus norvegicus (Rat)
  • CHO
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human
  • Human Cell
  • Human cells
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • Myc
  • His|Avi
  • His|GST
  • His|SUMO
  • His|T7
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ITGA6&ITGB1-608H Active Recombinant Human ITGA6&ITGB1 CHO N/A
Human ITGB1-1484H Active Recombinant Human Integrin, Beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) Human N/A
Human ITGA10&ITGB1-1039H Active Recombinant Human ITGA10&ITGB1 CHO N/A
Human ITGA2&ITGB1-738H Active Recombinant Human ITGA2&ITGB1 CHO N/A
Human ITGAV&ITGB1-740H Active Recombinant Human ITGAV&ITGB1 CHO N/A
Human ITGB1-26860TH Recombinant Human ITGB1 protein Wheat Germ N/A
Human ITGA4-161H Recombinant Human ITGA4 & ITGB1, Flag & His tagged Human Cell His
Human ITGB1-1181H Recombinant Human Integrin, Beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12), GST-tagged E.coli GST
Human ITGB1-2484H Recombinant human ITGB1, His-tagged E.coli His
Human ITGB1-233H Recombinant Human ITGB1 Protein, His-tagged HEK293 His
Human ITGB1-5770H Recombinant Human ITGB1 protein, His & GST-tagged E.coli His/GST Gln467~Thr635 (Accession # P05556)
Human ITGA6 & ITGB1-1878HCL Recombinant Human ITGA6 & ITGB1 cell lysate Human Cell N/A
Human ITGB1-5127HCL Recombinant Human ITGB1 293 Cell Lysate HEK293 N/A
Human ITGB1-5128HCL Recombinant Human ITGB1 293 Cell Lysate HEK293 N/A
Human ITGA8 & ITGB1-1876HCL Recombinant Human ITGA8 & ITGB1 cell lysate Human Cell N/A
Human ITGA5 & ITGB1-1877HCL Recombinant Human ITGA5 & ITGB1 cell lysate Human Cell N/A
Human ITGA6 & ITGB1-609H Recombinant Human ITGA6 & ITGB1 Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi
Human ITGB1-152H Recombinant Human ITGB1 Protein, His-tagged Human cells His
Human ITGB1-4986H Recombinant Human ITGB1 Protein, GST-tagged Wheat Germ GST
Human ITGB1-151H Recombinant Human ITGB1 Protein, His-tagged Human cells His
Human ITGAV & ITGB1-746H Active Recombinant Human ITGAV & ITGB1 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Phe31-Val992(ITGAV)&Gly27-Asp718(ITGB3)
Human CDA071P Recombinant Human CD29 E.coli N/A
Human ITGA4 & ITGB1-162H Active Recombinant Human ITGA4 & ITGB1 Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi
Human ITGB1-3007H Recombinant Human ITGB1 protein, His-tagged E.coli His 600-728 aa
Human ITGB1-4594H Recombinant Human ITGB1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ITGB1-4325H Recombinant Human ITGB1 Protein (Met1-Asp728), C-His tagged Mammalian cells C-His Met1-Asp728
Human ITGA5 & ITGB1-1877H Active Recombinant Human ITGA5 & ITGB1 Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi
Human ITGB1-266HF Recombinant Full Length Human ITGB1 Protein In Vitro Cell Free System
Human Itgb1 -1624H Active Recombinant Human Itgb1  protein, His-tagged HEK293 His Phe24-Gly1012|Asn28-Ser710
Human ITGB1-5754HF Recombinant Full Length Human ITGB1 Protein, GST-tagged In Vitro Cell Free System GST 798 amino acids
Human ITGB1-6195H Recombinant Human ITGB1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ITGB1-1295H Recombinant Human ITGB1 Protein (Gln21-Asp728), N-His tagged E.coli N-His Gln21-Asp728
Human ITGB1-6963HF Recombinant Full Length Human ITGB1 Protein In Vitro Cell Free System 798 amino acids
Mouse Itga10&Itgb1-664M Active Recombinant Mouse Itga10&Itgb1 CHO N/A
Mouse Itga4&Itgb1-347M Active Recombinant Mouse Itga4&Itgb1 CHO N/A
Mouse Itga9&Itgb1-516M Active Recombinant Mouse Itga9&Itgb1 CHO N/A
Mouse Itgb1-5771M Recombinant Mouse Itgb1 protein, His & T7-tagged E.coli His/T7 Val454~Ile714 (Accession # P09055)
Mouse ITGB1-8361M Recombinant Mouse ITGB1 Protein Mammalian Cell His
Mouse Itgb1-15M Recombinant Mouse Itgb1 protein, His-tagged E.coli His Val454~Ile714
Mouse ITGB1-4642M Recombinant Mouse ITGB1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Itgb1-3603M Recombinant Mouse Itgb1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Itgb1-3125M Recombinant Mouse Itgb1 protein, His-tagged E.coli His 21-728aa
Mouse ITGB1-4642M-B Recombinant Mouse ITGB1 Protein Pre-coupled Magnetic Beads HEK293
Rat ITGB1-3114R Recombinant Rat ITGB1 Protein Mammalian Cell His
Rat ITGB1-2770R Recombinant Rat ITGB1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ITGB1-2770R-B Recombinant Rat ITGB1 Protein Pre-coupled Magnetic Beads HEK293
Rat ITGB1-590R Recombinant Rat ITGB1 Protein (21-729 aa), His-SUMO-tagged E.coli His/SUMO 21-729 aa
Bos taurus (Bovine) RFL10882BF Recombinant Full Length Bovine Integrin Beta-1(Itgb1) Protein, His-Tagged E.coli expression system His Full Length (21-798)
Camelus bactrianus (Bactrian camel) RFL2580CF Recombinant Full Length Camelus Bactrianus Integrin Beta-1(Itgb1) Protein, His-Tagged E.coli expression system His Full Length (21-798)
Felis catus (Cat) (Felis silvestris catus) RFL21541FF Recombinant Full Length Cat Integrin Beta-1(Itgb1) Protein, His-Tagged E.coli expression system His Full Length (21-798)
Gallus gallus (Chicken) RFL3282GF Recombinant Full Length Chicken Integrin Beta-1(Itgb1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (25-803)
Homo sapiens (Human) RFL23428HF Recombinant Full Length Human Integrin Beta-1(Itgb1) Protein, His-Tagged E.coli expression system His Full Length (21-798)
Mus musculus (Mouse) RFL32665MF Recombinant Full Length Mouse Integrin Beta-1(Itgb1) Protein, His-Tagged E.coli expression system His Full Length (21-798)
Ovis aries (Sheep) RFL13472OF Recombinant Full Length Sheep Integrin Beta-1(Itgb1) Protein, His-Tagged E.coli expression system His Full Length (21-798)
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) RFL26356PF Recombinant Full Length Pongo Abelii Integrin Beta-1(Itgb1) Protein, His-Tagged E.coli expression system His Full Length (21-798)
Rattus norvegicus (Rat) RFL3854RF Recombinant Full Length Rat Integrin Beta-1(Itgb1) Protein, His-Tagged E.coli expression system His Full Length (21-798)
Pig ITGB1-4899P Recombinant Pig ITGB1 protein, His&Myc-tagged E.coli His&Myc 140-378aa
Chicken ITGB1-3321C Recombinant Chicken ITGB1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ITGB1 Related Articles

ITGB1 involved in several pathways and played different roles in them. We selected most pathways ITGB1 participated on our site, such as Rap signaling pathway, Phagosome, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Rap signaling pathwayFGF17;GRIN1;MAPK1;PIK3CB;RRAS;MLLT4;AKT2;ANGPT1;IGF1R
PhagosomeCALR;TUBA8L3;TUBA1B;TUBB1;ATP6V0A1A;ATP6V0A1;FCGR4;CTSSB.1;TLR2
PIK-Akt signaling pathwayPKN2;FN1;ANGPT2;FGF3;CCND1;IFNB1;LAMB4;PTK2;RAC1
Axon guidanceITGB3A;CFL2;EPHB4A;EPHA4A;FGFR1B;FRS2A;GNAI1;NCAN;ROBO1
Focal adhesionCOL5A2;MYL5;PRKCBA;VEGFB;PDGFRA;PIK3CD;ZYX;COL6A2;PAK2
ECM-receptor interactionTNW;LAMC1;COL27A1A;Npnt;THBS3;CD47;SDC4;LAMB2;CD44
Cell adhesion molecules (CAMs)MPZL1;CADM1A;CLDN19;PECAM1;CLDN3;ITGB1A;HLA-DRB4;VCAM1;HLA-E
Platelet activationGP6;RHOA;GNAI2;STIM1;GNAI3;PIK3R2;MAPK3;PRKACA;P2RX1
Leukocyte transendothelial migrationNCF1;GNAI3;RASSF5;ACTN2;EZR;VAV1;ACTN1;ACTN3;MYL10
Regulation of actin cytoskeletonITGB2L;CHRM5A;ARHGEF1;PIP5K1BA;Itga10&Itgb1;FGF17;PPP1CA;PIK3R1;BDKRB1
Bacterial invasion of epithelial cellsPIK3R5;ARPC1A;ELMO2;RHOA;PXN;SEPT9;SHC1;SRC;VCL
Pathogenic Escherichia coli infectionTUBA4A;ROCK1;ACTB;NCK2;ARHGEF2;TUBB1;NCK1;TUBA1B;ACTG1
ShigellosisPFN1;IL-8;MAPK10;MAD2L2;ITGA5;ACTG1;MAPK12;NFKB1;ELMO1
PertussisNLRP3;Casp3;C1RA;MAPK1;CFL2;C4BP;ITGAM;CALM3;ITGB2L
LeishmaniasisIL1B;MYD88;IL1A;CYBA;MAPK13;HLA-DQA2;FCGR1A;NCF4;HLA-DRA
ToxoplasmosisNFKBIB;GNAI2;RELA;GNAI1;PIK3R5;GNAI3;AKT1;IL10RB;MAPK11
Pathways in cancerIL-8;CXCR4;PLCB2;BIRC2;HDAC1;ITGA6;RAC1;GNG7;RXRG
Proteoglycans in cancerPRKACG;FAS;WNT2B;PTPN6;WNT9A;TP53;NANOG;ARHGEF1;CAV1
Small cell lung cancerPIAS2;PIK3CB;BIRC7;TRAF6;COL4A1;IKBKB;CKS2;BIRC3;ITGAV
Hypertrophic cardiomyopathy (HCM)Itga10&Itgb1;ITGA2B;ITGA4;ITGB5;TPM2;ATP2A2;ITGA10;CACNB2;ACTB
Arrhythmogenic right ventricular cardiomyopathy (ARVC)ITGA6;ITGA10;DSC2;CACNG8;CACNB2;ITGB5;ITGA1;ACTN4;Itga10&Itgb1
Dilated cardiomyopathyTPM4;PRKACG;CACNA2D2;SGCD;ITGA6;PLN;SLC8A1;ITGA2B;DES

ITGB1 has several biochemical functions, for example, actin binding, cell adhesion molecule binding, collagen binding involved in cell-matrix adhesion. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGB1 itself. We selected most functions ITGB1 had, and list some proteins which have the same functions with ITGB1. You can find most of the proteins on our site.

Function Related Protein
actin bindingMYO3B;MYH15;DAAM1B;WHAMM;HOOK1;CCDC88A;MYO5C;MICAL1;FLNC
cell adhesion molecule bindingCD1D;ITGB1;PKP3;GLYCAM1;EZR;CAML;NPTN;PVRL3;LPHN1
collagen binding involved in cell-matrix adhesionITGA2;ITGB1;ITGA10;Itga10&Itgb1;ITGA1
fibronectin bindingCTGF;ITGB1A;ITGB3;SFRP2;HSD17B12;MFAP2;CTSL1;MMP13;FSTL3
integrin bindingANXA7;CIB2;Tcam1;ICAM5;NF2;FBN1;NOV;PXN;WISP1
laminin bindingECM1;ITGA3;ACHE;BCAM;TINAGL1;PLEKHA2;ADAM9;LYPD5;RPSA
metal ion bindingZFP276;ZNF615;TOPAZ1;NT5C2A;PRKCHB;SLC2A4RG;ZNF812;ATP1A1A.2;NT5C2
protease bindingTNF;CD28;ITGB3;NFRKB;CFLAR;Cstb;SERPINB13;TIMP4;CST3
protein bindingCANX;RARRES3;KCNA3;MLLT6;GCC1;HNRNPC;ING2;DOHH;GRK5
protein heterodimerization activityCHRAC1;SYT5;HIST1H3H;HIST3H2BB;H2AFVB;ZHX3;MAFGB;BCL11A;CLCF1
virus receptor activityCLEC4G;IDE;DPP4;CD209A;ITGAV;ITGA2;CLEC4M;CD209;TNFRSF4

ITGB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGB1.

FLNA; ITGA5; VCAM1; ITGA4

Harati, K; Slodnik, P; et al. Pro-apoptotic effects of pycnogenol on HT1080 human fibrosarcoma cells. INTERNATIONAL JOURNAL OF ONCOLOGY 46:1629-1636(2015).
Tsai, YC; Hsiao, WH; et al. Genomic single nucleotide polymorphisms in the offspring of gastric cancer patients predispose to spasmolytic polypeptide-expressing metaplasia after H. pylori infection. JOURNAL OF BIOMEDICAL SCIENCE 22:-(2015).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
Are there have therapeutic strategies for ITGB1 protein? 08/20/2023

Therapeutic strategies for ITGB1 protein may include inhibiting its expression, blocking its binding to ligands, or regulating its associated signal transduction pathways. These methods may have potential applications in cancer treatment.

What are the interactions between ITGB1 protein and other proteins? 04/14/2023

The ITGB1 protein can interact with a variety of other proteins, including ligands, proteins in signal transduction pathways, etc. These interactions enable it to regulate processes such as cell growth, differentiation, and apoptosis.

How about the specific role of ITGB1 protein in cancer? 04/18/2022

In cancer, ITGB1 protein may play a role by promoting processes such as the proliferation, migration and invasion of tumor cells, thus promoting the occurrence and development of tumors. It could be a potential target for cancer treatment.

Which is the main function of ITGB1 protein in cells? 03/31/2022

The main function of ITGB1 protein in cells is to act as a cell adhesion receptor, participate in the interaction between cells and extracellular matrix, and play an important role in cell migration and signal transduction.

What is the relationship between ITGB1 protein structure and function? 12/05/2020

The structure of the ITGB1 protein determines its ability and stability to bind to ligands. The study of its structure can help us understand its function and mechanism of action.

How about the association between ITGB1 protein expression level and disease? 02/23/2020

Recent literature has shown that the expression level of ITGB1 protein is related to the occurrence and development of a variety of diseases, including cancer, cardiovascular diseases, neurodegenerative diseases, etc.

Customer Reviews (3)

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Reviews
06/24/2023

    The range of applications for ITGB1 is impressive, and it can play an important role in any field.

    04/19/2023

      ITGB1 performed very well in Western blot, with clear bands and improved experimental accuracy.

      05/29/2021

        ITGB1 has a strong desensitization potential for specific allergens.

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