| Description : |
Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1 and recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma mbranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assbly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and GNB2L1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis. |
| Source : |
E. coli |
| Species : |
Rat |
| Tag : |
His-SUMO |
| Form : |
Tris-based buffer, 50% glycerol |
| Molecular Mass : |
94.4 kDa |
| Protein length : |
21-729 aa |
| AA Sequence : |
QTDKNRCLKANAKSCGECIQAGPNC GWCTNTTFLQEGMPTSARCDDLEAL KKKGCHPSDIENPRGSQTIKKNKNV TNRSKGMAEKLRPEDITQIQPQQLL LKLRSGEPQKFTLKFKRAEDYPIDL YYLMDLSYSMKDDLENVKSLGTDLM NEMRRITSDFRIGFGSFVEKTVMPY ISTTPAKLRNPCTSEQNCTSPFSYK NVLSLTDRGEFFNELVGQQRISGNL DSPEGGFDAIMQVAVCGSLIGWRNV TRLLVFSTDAGFHFAGDGKLGGIVL PNDGQCHLENNVYTMSHYYDYPSIA HLVQKLSENNIQTIFAVTEEFQPVY KELKNLIPKSAVGTLSGNSSNVIQL IIDAYNSLSSEVILENSKLPDGVTI NYKSYCKNGVNGTGENGRKCSNISI GDEVQFEISITANKCPNKESENQLK LNPLGFTEEVEVVLQFICKCNCQSH GIPASPKCHEGNGTFECGACRCNEG RVGRHCECSTDEVNSEDMDAYCRKE NSSEICSNNGECVCGQCVCRKRENT NEIYSGKFCECDNFNCDRSNGLICG GNGVCRCRVCECYPNYTGSACDCSL DTVPCVATNGQICNGRGICECGACK CTDPKFQGPTCETCQTCLGVCAEHK ECVQCRAFNKGEKKDTCAQECSHFN LTKVESREKLPQPVQVDPVTHCKEK DIDDCWFYFTYSVNSKGEAHVHVVE TPDCPTGPD |
| Purity : |
> 90% as determined by SDS-PAGE. |
| Notes : |
Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week. |
| Storage : |
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade. |
| Concentration : |
A hardcopy of COA with concentration instruction is sent along with the products. |
