ITPR3

  • Official Full Name

    inositol 1,4,5-trisphosphate receptor, type 3
  • Overview

    Inositol 1,4,5-triphosphate receptor, also known as IP3R or InsP3R, is a member of the intracellular calcium release channel family and is located in the endoplasmic reticulum. IP3R functions as a Ca2+ release channel for intracellular stores of calcium i
  • Synonyms

    ITPR3;inositol 1,4,5-trisphosphate receptor, type 3;inositol 1,4,5 triphosphate receptor, type 3;inositol 1,4,5-trisphosphate receptor type 3;IP3R3;insP3R3;IP3 receptor;type 3 InsP3 receptor;inositol 1,4,5-triphosphate receptor, type 3;IP3R;FLJ3

Recombinant Proteins

  • Rat
  • Zebrafish
  • Mouse
  • Human
  • Mammalian Cells
  • E.coli
  • HEK293
  • Yeast
  • Baculovirus
  • Mammalian cells
  • His
  • GST
  • Avi
  • Fc
  • Non
Cat.# Product name Source (Host) Species Tag Protein Length Price
ITPR3-3127R Recombinant Rat ITPR3 Protein Mammalian Cells Rat His
ITPR3-6830Z Recombinant Zebrafish ITPR3 Mammalian Cells Zebrafish His
ITPR3-8391M Recombinant Mouse ITPR3 Protein Mammalian Cells Mouse His
ITPR3-1701H Recombinant Human ITPR3 Protein, His&GST-tagged E.coli Human GST&His Phe2389-Asp2496
ITPR3-2783R Recombinant Rat ITPR3 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
ITPR3-2783R-B Recombinant Rat ITPR3 Protein Pre-coupled Magnetic Beads HEK293 Rat
ITPR3-4656M Recombinant Mouse ITPR3 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
ITPR3-4656M-B Recombinant Mouse ITPR3 Protein Pre-coupled Magnetic Beads HEK293 Mouse
Itpr3-5103M Recombinant Mouse Itpr3 protein Yeast Mouse Non
Itpr3-5104M Recombinant Mouse Itpr3 protein E.coli Mouse Non
Itpr3-5105M Recombinant Mouse Itpr3 protein, Avi-tagged, Biotinylated E.coli Mouse Avi
Itpr3-5106M Recombinant Mouse Itpr3 protein Baculovirus Mouse Non
Itpr3-5107M Recombinant Mouse Itpr3 protein Mammalian cells Mouse Non

    Involved Pathway

    ITPR3 involved in several pathways and played different roles in them. We selected most pathways ITPR3 participated on our site, such as Calcium signaling pathway,cGMP-PKG signaling pathway,Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITPR3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Insulin secretion CCKAR,GIP,ATP1A1,PRKACB,SNAP25,PRKCA,ATP1A2,CREB5,FFAR1,KCNMB2
    Retrograde endocannabinoid signaling GNG3,GNB1,GNAI3,PLCB3,MAPK3,GNAI2,SLC17A8,GNG12,GABRA6,PLCB4
    Phosphatidylinositol signaling system ITPKB,PPIP5K1,DGKAA,PIP4K2A,CALM2B,OCRL,MTMR2,PIK3CA,IPMK,INPP4A
    Circadian entrainment PRKACG,GNG7,GRIA4,PRKCA,GNAQ,MTNR1B,GNAI2,GNG4,NOS1,KCNJ9
    Oocyte meiosis IGF1RB,PPP3CCA,PPP1R2P9,PRKACA,YWHAB,PPP2CA,MOS,YWHAG1,PPP1CA,ITPR1
    Gap junction KRAS,TUBA2,MAP2K1,TUBA8L,CX35B,Pdgfa&Pdgfb,TUBA1L,TUBB1,TUBA1B,PRKG1
    Platelet activation PPP1CC,ARHGEF1,ARHGAP35,PLCB1,VASP,MYLK4,SNAP23,FCGR2A,PIK3R3,MYLK3
    Oxytocin signaling pathway MAPK1,PRKACG,KCNJ14,CACNA2D2,MYLK4,GNAO1,PLA2G4F,PRKAB2,CAMK1G,GNAI1
    Dopaminergic synapse MAPK13,GNAS,CALY,KCNJ5,ARRB2,PPP1CB,GNAO1,MAOB,PPP2R2D,ATF6B

    Protein Function

    ITPR3 has several biochemical functions, for example, calcium channel activity,calcium ion binding,inositol 1,3,4,5 tetrakisphosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITPR3 itself. We selected most functions ITPR3 had, and list some proteins which have the same functions with ITPR3. You can find most of the proteins on our site.

    Function Related Protein
    inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity ITPR2,AKR1C1,ITPR1
    inositol hexakisphosphate binding AKR1C1
    intracellular ligand-gated calcium channel activity TRPA1,ITPR1,RYR2,AKR1C1
    calcium channel activity MCU,GPM6A,TRPM1,SLC24A4A,AKR1C1,ORAI1B,PKD2L2,TRPC5A,CACNG2B,SLC24A5
    inositol 1,4,5 trisphosphate binding TRPC3,TRPC6,TRPC4,TRPC6A,TRPC2B,CYTH2,RPH3A,TRPC7,PLCL1,TRPC1
    phosphatidylinositol binding PASK,FES,CCDC88A,MTM1,SNX31,SNX6,FCHO2,TULP4A,PIK3C2B,SNX27A
    calcium ion binding SRR,TNNC1B,LDLRA,PADI2,PVALB9,PCDH2G6,GUCA1D,PROC,CAMKK2,TMEM8C
    inositol 1,3,4,5 tetrakisphosphate binding ADAP2,AKR1C1,SYT2,ADAP1
    protein binding ZAK,TIMP3,KIRREL3,MPZL1,CCDC112,MYO15,AGPS,APTX,BLOC1S1,TMEM86B

    Interacting Protein

    ITPR3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITPR3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITPR3.

    Abcf1;Lrmp

    Resources

    References

    • MARANTO, AR; et al. PRIMARY STRUCTURE, LIGAND-BINDING, AND LOCALIZATION OF THE HUMAN TYPE-3 INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR EXPRESSED IN INTESTINAL EPITHELIUM. JOURNAL OF BIOLOGICAL CHEMISTRY 269:1222-1230(1994).

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