ITPR3
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Official Full Name
inositol 1,4,5-trisphosphate receptor, type 3 -
Overview
Inositol 1,4,5-triphosphate receptor, also known as IP3R or InsP3R, is a member of the intracellular calcium release channel family and is located in the endoplasmic reticulum. IP3R functions as a Ca2+ release channel for intracellular stores of calcium i -
Synonyms
ITPR3;inositol 1,4,5-trisphosphate receptor, type 3;inositol 1,4,5 triphosphate receptor, type 3;inositol 1,4,5-trisphosphate receptor type 3;IP3R3;insP3R3;IP3 receptor;type 3 InsP3 receptor;inositol 1,4,5-triphosphate receptor, type 3;IP3R;FLJ3
Recombinant Proteins
- Rat
- Zebrafish
- Mouse
- Human
- Mammalian Cells
- E.coli
- HEK293
- Yeast
- Baculovirus
- Mammalian cells
- His
- GST
- Avi
- Fc
- Non
Involved Pathway
ITPR3 involved in several pathways and played different roles in them. We selected most pathways ITPR3 participated on our site, such as Calcium signaling pathway,cGMP-PKG signaling pathway,Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITPR3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Retrograde endocannabinoid signaling | MAPK8,GRIA2,GABRG3,GRM1,GRIA3,PLCB3,PRKCA,GABRR3,GNB2,GABRA2 |
| Platelet activation | MYLK2,PRKACA,GUCY1A3,RHOA,ITGA2B,MYLK3,PRKG1,FGA,LCP2,MAPK13 |
| Oxytocin signaling pathway | CACNB4,PRKACG,MYL9,PRKCA,PPP3CA,CAMKK1,TRPM2,PIK3R3,PPP1R12A,PRKACB |
| Alzheimers disease | COX8A,EIF2AK3,COX7B2,COX4I1,MT-ATP6,Casp3,PPP3CB,NDUFS4,MME,PLCB2 |
| Oocyte meiosis | PPP2R5E,PPP1CBL,YWHAG1,PPP3R1B,CALM2A,MAPK3,ANAPC7,PPP2R1B,CALML5,RPS6KAL |
| Gastric acid secretion | CALM4,CAMK2A,CALM3,GAST,CALM1,EZR,KCNK2,ATP1B1,SLC9A4,ACTB |
| Glutamatergic synapse | GRIA4,GRM1,SHANK3,SLC1A2,MAPK1,GNG7,GRIK5,PRKACA,GRM5,ADRBK2 |
| Renin secretion | GNAI1,AGTR1A,CALM2,CLCA2,GUCY1B3,CLCA3,PRKACA,REN2,PPP3R2,PDE3A |
| Vascular smooth muscle contraction | MYH11,PLA2G2D,PLCB4,KCNMB2,ARAF,MYLK,MAP2K2B,MAP2K2,ARHGEF12,MLCK2 |
Protein Function
ITPR3 has several biochemical functions, for example, calcium channel activity,calcium ion binding,inositol 1,3,4,5 tetrakisphosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITPR3 itself. We selected most functions ITPR3 had, and list some proteins which have the same functions with ITPR3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | KLHDC3,IFT27,MYOZ1,TBX22,AIMP1,LTC4S,RGS19,AP2M1,ACSS1,NUP35 |
| inositol 1,3,4,5 tetrakisphosphate binding | AKR1C1,ADAP2,SYT2,ADAP1 |
| calcium channel activity | TRPC6A,TRPM8,CACNA1C,CACNG7A,CACNG1A,UBXN6,AKR1C1,CACFD1,CACNB2,CHRNA9 |
| calcium ion binding | NOTCH2NL,DHH,PVALB2,PCDHGB4,EFCAB3,COMP,TNNC2,CDHR1,MMP30,MYL3 |
| inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity | ITPR1,ITPR2,AKR1C1 |
| phosphatidylinositol binding | SNX33,RAG2,SEPT12,SNX12,TULP2,NOXO1,SNX1B,SNX2,SGK3,HIP1RB |
| ion channel activity | TRPC7A,TRPV5,RYR1B,CNGA4,CACNA1DA,KCNH5,TPC3,CHRNB1L,SCN12AB,FXYD5 |
| inositol hexakisphosphate binding | AKR1C1 |
| intracellular ligand-gated calcium channel activity | ITPR1,AKR1C1,RYR2,TRPA1 |
Interacting Protein
ITPR3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITPR3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITPR3.
Abcf1;Lrmp
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References
- MARANTO, AR; et al. PRIMARY STRUCTURE, LIGAND-BINDING, AND LOCALIZATION OF THE HUMAN TYPE-3 INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR EXPRESSED IN INTESTINAL EPITHELIUM. JOURNAL OF BIOLOGICAL CHEMISTRY 269:1222-1230(1994).
