KDM1A
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Official Full Name
lysine (K)-specific demethylase 1A -
Overview
This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009] -
Synonyms
KDM1A;lysine (K)-specific demethylase 1A;AOF2;KDM1;LSD1;BHC110;lysine-specific histone demethylase 1A;lysine (K)-specific demethylase 1;BRAF35-HDAC complex protein BHC110;lysine-specific histone demethylase 1;amine oxidase (flavin containing) domain 2;FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit;flavin-containing amine oxidase domain-containing protein 2
Recombinant Proteins
- Human
- Rhesus macaque
- Zebrafish
- Mouse
- E.coli
- Sf9 Cells
- Mammalian Cells
- Insect Cells
- In Vitro Cell Free System
- HEK293
- E. coli
- GST
- Non
- Flag
- His
- Avi
- Fc
- DDK
- Myc
Involved Pathway
KDM1A involved in several pathways and played different roles in them. We selected most pathways KDM1A participated on our site, such as Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3,Androgen receptor signaling pathway,Chromatin modifying enzymes, which may be useful for your reference. Also, other proteins which involved in the same pathway with KDM1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Androgen receptor signaling pathway | PSMC3IP,SMAD3B,CTNNB2,HTATIP,NR2C2,EFCAB6,CDKN1A,DAXX,NCOA2,STUB1 |
| HDACs deacetylate histones | CHD4,MBD3B,MTA2,ARID4A,GATAD2AB,MTA1,SAP30L,CHD4A,SAP18,SAP30 |
| Factors involved in megakaryocyte development and platelet production | KIF2B,MAFGB,HBBE2,HBBE3,KIFC1,MFN1,DOCK11,GATA5,D-AKAP2,BA2 |
| Chromatin modifying enzymes | SAP130,MORF4L1,PADI4,SETD3,MSL2B,PHF17,ING5,KDM2B,KIAA1267,ELP3 |
| HDMs demethylate histones | KDM3A,KDM5B,KDM3B,KDM5BB,KDM5D,KDM2A,KDM1B,KDM6B,KDM5C,KDM7AB |
| Coregulation of Androgen receptor activity | CMTM2A,MAK,SVIL,KDM4C,PIAS3,TMF1,PATZ1,TGFB1I1,SNURF,CARM1 |
| Chromatin organization | PADI3,PHF20B,KAT7B,ING5,ACTL6B,CSRP2BP,PRMT5,C3orf75,KDM4D,SMYD2 |
| Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | KDM4C,HIST2H3C,HIST4H4,NCOA2,HIST3H2BB |
Protein Function
KDM1A has several biochemical functions, for example, MRF binding,RNA polymerase II transcription factor binding,androgen receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KDM1A itself. We selected most functions KDM1A had, and list some proteins which have the same functions with KDM1A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| histone demethylase activity | KDM4C,PHF8,KDM2B |
| transcription regulatory region DNA binding | FOXA3,ZNF174,ZFP161,RNF10,BCOR,HMGB2,HNF1A,ATF3,Ar,ETV5 |
| oxidoreductase activity | DAO.1,C10orf33,OSGIN2,CYP4T8,C1orf43,ADI1,CYP3A41B,CYP46A1.1,CYP46A1.2,Scd1 |
| transcription factor binding | PPP1R13BA,PARP1,NR0B1,IRF4,NAB1,PPARGC1B,TAF7L,ESRRB,SOX17,SMAD2 |
| protein binding | NCOA5,NUAK1,RBBP5,ZNF581,C2orf88,CTF1,CLDN2,WDR74,CCDC109A,RPH3AL |
| enzyme binding | Il6ra,RXRA,HMGA1-RS1,ERN1,MTA1,CRB2,BLZF1,ZNHIT6,MARCH6,CPSF1 |
| MRF binding | CREBBP,BHLHE40,TSC22D3 |
| chromatin binding | GM606,SSRP1,PRMT6,RAD51,HMGB2,PSIP1,KDM5A,TWIST2,STAG1,ARNTL1B |
| histone demethylase activity (H3-K4 specific) | KDM5C,KDM5B,C14orf169,KDM5D |
Interacting Protein
KDM1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KDM1A here. Most of them are supplied by our site. Hope this information will be useful for your research of KDM1A.
SNAI1
KDM1A Related Signal Pathway
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