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Official Full Name kallikrein-related peptidase 7
Background This gene encodes a member of the kallikrein subfamily of serine proteases. These enzymes have diverse physiological functions and many kallikrein genes are biomarkers for cancer. The encoded protein has chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes desquamation, the shedding of the outermost layer of the epidermis. The encoded protein may play a role in cancer invasion and metastasis, and increased expression of this gene is associated with unfavorable prognosis and progression of several types of cancer. Polymorphisms in this gene may play a role in the development of atopic dermatitis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, which is one of fifteen kallikrein subfamily members located in a gene cluster on chromosome 19. [provided by RefSeq, May 2011]
Synonyms KLK7; kallikrein-related peptidase 7; hK7; SCCE; PRSS6; kallikrein-7; signal protein; serine protease 6; stratum corneum chymotryptic enzyme; kallikrein 7 (chymotryptic, stratum corneum)
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human
    • Human Cell
    • Mammalian cells
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human KLK7-3139H Recombinant Human KLK7 protein, GST-tagged E.coli GST
    Rat Klk7-3140R Recombinant Rat Klk7 protein, His-tagged E.coli His
    Human KLK7-1359H Recombinant Human Kallikrein-Related Peptidase 7 Human N/A
    Human KLK7-1959H Recombinant Human KLK7 protein, His & GST-tagged E.coli His/GST
    Human KLK7-2428HCL Recombinant Human KLK7 cell lysate Human Cell N/A
    Human KLK7-26893TH Recombinant Human KLK7 Wheat Germ N/A
    Human KLK7-4930H Recombinant Human KLK7 Protein, GST-tagged Wheat Germ GST
    Human KLK7-689H Recombinant Human KLK7 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human KLK7-7169H Recombinant Human Kallikrein-Related Peptidase 7, His-tagged E.coli His
    Human KLK7-889H Recombinant Human KLK7 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human KLK7-893H Recombinant Human KLK7, His tagged Human Cell His
    Human KLK7-894H Recombinant Human KLK7 HEK293 N/A
    Mouse KLK7-1421MCL Recombinant Mouse KLK7 cell lysate Human Cell N/A
    Mouse Klk7-1960M Recombinant Mouse Klk7 protein, His & GST-tagged E.coli His/GST
    Mouse Klk7-3726M Recombinant Mouse Klk7 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse KLK7-564M Recombinant Mouse KLK7 Protein, His-tagged Mammalian cells His
    Mouse Klk7-7405M Recombinant Mouse Klk7, His-tagged Human Cell His
    Rat Klk7-1961R Recombinant Rat Klk7 protein, His & GST-tagged E.coli His/GST

    KLK7 involved in several pathways and played different roles in them. We selected most pathways KLK7 participated on our site, such as Degradation of the extracellular matrix, Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with KLK7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Degradation of the extracellular matrix TIMP2; CTSD; MMP19; MMP12; ACAN; EMID2; ADAMTS5; KLK7; TIMP2B; MGC174152
    Extracellular matrix organization JAM2B; PRP; COL10A1; FAM49BA; COL6A1; COL1A1; COL4A6; PCOLCE2B; COL11A1B; HAPLN1

    KLK7 has several biochemical functions, for example, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KLK7 itself. We selected most functions KLK7 had, and list some proteins which have the same functions with KLK7. You can find most of the proteins on our site.

    Function Related Protein
    peptidase activity CELA3B; KLK5; HM13; PRSS42; IHH; MMP14A; MBTPS2; USP12A; OTUD4; KLK1B5
    serine-type endopeptidase activity GZMA; CTSG; PRSS59.1; PCSK4; F12; APEH; PRSS44; TPP1; PRSS7; PROCA
    serine-type peptidase activity TMPRSS7; F9A; PRSS59.2; KEX2; TMPRSS11E; TRY; GZMK; GM5077; KLK1B5; MCPT9

    KLK7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLK7 here. Most of them are supplied by our site. Hope this information will be useful for your research of KLK7.


    Yamamuro, T; Hori, M; et al. Tickling stimulation causes the up-regulation of the kallikrein family in the submandibular gland of the rat. BEHAVIOURAL BRAIN RESEARCH 236:236-243(2013).
    Yamamoto, M; Miyai, M; et al. Kallikrein-related Peptidase-7 Regulates Caspase-14 Maturation during Keratinocyte Terminal Differentiation by Generating an Intermediate Form. JOURNAL OF BIOLOGICAL CHEMISTRY 287:32825-32834(2012).

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