LAT
-
Official Full Name
linker for activation of T cells
-
Overview
Linker for activation of T cells (LAT) is a 36 kDa transmembrane adapter protein that is tyrosine- phosphorylated following T-cell receptor (TCR) stimulation by ZAP-70 and Syk. Four distal tyrosine residues (#132, #171, #191 and #226 in human LAT) are cru -
Synonyms
LAT; linker for activation of T cells; linker for activation of T-cells family member 1; LAT1; transmembrane adaptor; p36-38; 36 kDa phospho-tyrosine adapter protein; 36 kDa phospho-tyrosine adaptor protein; linker for activation of T cells, transmembrane adaptor; pp36;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Rat
- Rattus norvegicus (Rat)
- Zebrafish
- E. coli
- E.coli
- E.coli expression system
- HEK293
- Mammalian Cell
- His
- Fc
- Avi
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
LAT involved in several pathways and played different roles in them. We selected most pathways LAT participated on our site, such as Ras signaling pathway, Rap signaling pathway, NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with LAT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ras signaling pathway | PDGFRA;KIT;MLLT4;FGF7;PLA2G10;PAK7;PAK1;FGF3;PLA2G2D |
| Rap signaling pathway | LPAR2;PDGFRA;RAF1;INS1;Adcy4;PRKCB;SRC;GNAI1;PRKD3 |
| NF-kappa B signaling pathway | UBE2I;CCL4L2;LTB;BLNK;NFKB1;TRAF6;TNFSF14;TRADD;NFKBIA |
| Natural killer cell mediated cytotoxicity | ARAF;Ifna11;PLCG1;PPP3CB;HLA-E;KIR2DL3;BRAF;PLCG2;PTK2B |
| T cell receptor signaling pathway | GRAPA;PIK3CG;PPP3CC;LCK;FOS;LAT;ICOS;MAPK9;GSK3B |
| Fc epsilon RI signaling pathway | PLCG1;VAV2;GAB2;MAP2K3;IL3;RAC3;PIK3R5;PLCG2;MAPK12 |
| Fc gamma R-mediated phagocytosis | WASF2;WASF1;PRKCG;PLA2G4F;NCF1;MAPK3;INPPL1;PIP5K1B;MAPK1 |
LAT has several biochemical functions, for example, SH3/SH2 adaptor activity, protein binding, protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LAT itself. We selected most functions LAT had, and list some proteins which have the same functions with LAT. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| SH3/SH2 adaptor activity | CRK;SLA;STAP1;PTPN11;SH2D3C;TOB1;HSH2D;GRB14;SHB |
| protein binding | PRKAR1A;RBKS;TRAPPC10;KPNA3;SPRY1;CRYGD;GOPC;LY96;RRAGB |
| protein kinase binding | SKAP1;CAMK2N1A;FAM83E;RAD9A;STK11IP;GRIN2A;CD4;CDKN2C;E2F1 |
LAT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LAT here. Most of them are supplied by our site. Hope this information will be useful for your research of LAT.
GRB2; PLCG1; PTPN1
Research Area
Related articles
- Reviews
- Q&As
Ask a Question for All LAT Products
Required fields are marked with *
My Review for All LAT Products
Required fields are marked with *
