LAT

  • Official Full Name

    linker for activation of T cells

  • Overview

    Linker for activation of T cells (LAT) is a 36 kDa transmembrane adapter protein that is tyrosine- phosphorylated following T-cell receptor (TCR) stimulation by ZAP-70 and Syk. Four distal tyrosine residues (#132, #171, #191 and #226 in human LAT) are cru
  • Synonyms

    LAT; linker for activation of T cells; linker for activation of T-cells family member 1; LAT1; transmembrane adaptor; p36-38; 36 kDa phospho-tyrosine adapter protein; 36 kDa phospho-tyrosine adaptor protein; linker for activation of T cells, transmembrane adaptor; pp36;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human LAT-335H Recombinant Human LAT Protein, His-tagged E.coli His Leu25~Glu221
Human LAT-6882H Recombinant Human Linker For Activation Of T Cells, His-tagged E.coli His 28-233aa
Human LAT-29047TH Recombinant Human LAT, His-tagged E.coli His 206 amino acids
Human LAT-4816HCL Recombinant Human LAT 293 Cell Lysate HEK293 N/A
Human LAT-4817HCL Recombinant Human LAT 293 Cell Lysate HEK293 N/A
Mouse Lat-336M Recombinant Mouse Lat Protein, His-tagged E.coli His Cys30~Asn237
Mouse LAT-8969M Recombinant Mouse LAT Protein Mammalian Cell His
Mouse LAT-5002M Recombinant Mouse LAT Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse LAT-5002M-B Recombinant Mouse LAT Protein Pre-coupled Magnetic Beads HEK293
Rat Lat-337R Recombinant Rat Lat Protein, His-tagged E.coli His Leu33~Asp227
Rat LAT-3359R Recombinant Rat LAT Protein Mammalian Cell His
Rat LAT-3015R-B Recombinant Rat LAT Protein Pre-coupled Magnetic Beads HEK293
Rat LAT-3015R Recombinant Rat LAT Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Homo sapiens (Human) RFL12746HF Recombinant Full Length Human Linker For Activation Of T-Cells Family Member 1(Lat) Protein, His-Tagged E.coli expression system His Full Length (1-262)
Mus musculus (Mouse) RFL20533MF Recombinant Full Length Mouse Linker For Activation Of T-Cells Family Member 1(Lat) Protein, His-Tagged E.coli expression system His Full Length (1-242)
Rattus norvegicus (Rat) RFL6498RF Recombinant Full Length Rat Linker For Activation Of T-Cells Family Member 1(Lat) Protein, His-Tagged E.coli expression system His Full Length (1-241)
Zebrafish LAT-7255Z Recombinant Zebrafish LAT Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

LAT involved in several pathways and played different roles in them. We selected most pathways LAT participated on our site, such as Ras signaling pathway, Rap signaling pathway, NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with LAT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ras signaling pathwayGNG2;GNG4;PLA2G3;FGF3;PLA2G4C;SOS1;GRIN1;MLLT4;PLA2G12B
Rap signaling pathwayAPBB1IP;RRAS;SKAP1;INS;CALM3;FLT1;PFN2;FGFR2;GNAQ
NF-kappa B signaling pathwayIL1B;CD40;ICAM1;LTB;TRAF1;LBP;GM13304;TNF;IRAK1
Natural killer cell mediated cytotoxicityVAV1;KIR2DS3;SOS1;PRKCB;KLRD1;KIR3DL1;PIK3CG;TNFRSF10C;NFATC2
T cell receptor signaling pathwayMAPK9;NCK1;PIK3R2;LAT;PTPN6;IFNG;RHOA;VAV2;MAPK13
Fc epsilon RI signaling pathwayMAP2K7;PIK3R3;LYN;GAB2;MAPK11;PLA2G4B;LAT;MAP2K2;VAV1
Fc gamma R-mediated phagocytosisAKT1;ARPC5L;SCIN;RAC2;CFL1;cgr2b;ASAP2;AMPH;ARPC1A

LAT has several biochemical functions, for example, SH3/SH2 adaptor activity, protein binding, protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LAT itself. We selected most functions LAT had, and list some proteins which have the same functions with LAT. You can find most of the proteins on our site.

Function Related Protein
SH3/SH2 adaptor activityARHGAP1;PTPN11;SH2B2;GRB14;GRB10;CHN2;SOCS2;GRAP;ARHGAP4
protein bindingRTKN;SPON1;EPM2A;IRS2;LIMK2;SLC26A6;DVL2;ZCCHC8;SNRNP25
protein kinase bindingSPDYA;PIH1D1;IRS2;H2AFY;CCND2;TRP53;MAPK6;JAK2;PLCG1

LAT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LAT here. Most of them are supplied by our site. Hope this information will be useful for your research of LAT.

GRB2; PLCG1; PTPN1

Research Area

Related articles

Finch, ML; Passman, AM; et al. Sub-Cellular Localisation Studies May Spuriously Detect the Yes-Associated Protein, YAP, in Nucleoli Leading to Potentially Invalid Conclusions of Its Function. PLOS ONE 10:-(2015).
Du, T; Han, ZY; et al. Patterns of accumulation of miRNAs encoded by herpes simplex virus during productive infection, latency, and on reactivation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112:E49-E55(2015).
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