Recombinant Human Linker For Activation Of T Cells, His-tagged
Cat.No. : | LAT-6882H |
Product Overview : | Recombinant human LAT protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques. MW: 24.4 kDa. |
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Description : | LAT is an integral membrane protein which is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. LAT is expressed in T lymphocytes in interstitial spaces, platelets and megakaryocytes. LAT is not expressed in B cells, macrophages, plasma cells, monocytes, epithelial histiocytes and dendritic cells. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Liquid. In 20mM Tris-HCl buffer(pH 8.0) containing 1mM DTT. |
Molecular Mass : | 24.4 kDa (227aa), confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher). |
Protein length : | 28-233aa |
AA Sequence : | MGSSHHHHHH SSGLVPRGSH MHCHRLPGSY DSTSSDSLYP RGIQFKRPHT VAPWPPAYPP VTSYPPLSQP DLLPIPRSPQ PLGGSHRTPS SRRDSDGANS VASYENEEPA CEDADEDEDD YHNPGYLVVL PDSTPATSTA APSAPALSTP GIRDSAFSME SIDDYVNVPE SGESAEASLD GSREYVNVSQ ELHPGAAKTE PAALSSQEAE EVEEEGAPDY ENLQELN |
Purity : | >95% by SDS - PAGE |
Applications : | SDS-PAGE |
Storage : | Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Concentration : | 1 mg/ml (determined by Bradford) |
Gene Name : | LAT linker for activation of T cells [ Homo sapiens ] |
Official Symbol : | LAT |
Synonyms : | LAT; linker for activation of T cells; linker for activation of T-cells family member 1; LAT1; transmembrane adaptor; p36-38; 36 kDa phospho-tyrosine adapter protein; 36 kDa phospho-tyrosine adaptor protein; linker for activation of T cells, transmembrane adaptor; pp36; |
Gene ID : | 27040 |
mRNA Refseq : | NM_001014987 |
Protein Refseq : | NP_001014987 |
MIM : | 602354 |
UniProt ID : | O43561 |
Chromosome Location : | 16q13 |
Pathway : | Adaptive Immune System, organism-specific biosystem; Fc epsilon RI signaling pathway, organism-specific biosystem; Fc epsilon RI signaling pathway, conserved biosystem; Fc gamma R-mediated phagocytosis, organism-specific biosystem; Fc gamma R-mediated phagocytosis, conserved biosystem; Fc-epsilon receptor I signaling in mast cells, organism-specific biosystem; GPVI-mediated activation cascade, organism-specific biosystem; |
Function : | SH3/SH2 adaptor activity; protein binding; protein kinase binding; |
Products Types
◆ Recombinant Protein | ||
LAT-5002M | Recombinant Mouse LAT Protein, His (Fc)-Avi-tagged | +Inquiry |
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LAT-29047TH | Recombinant Human LAT, His-tagged | +Inquiry |
LAT-335H | Recombinant Human LAT Protein, His-tagged | +Inquiry |
Lat-336M | Recombinant Mouse Lat Protein, His-tagged | +Inquiry |
◆ Lysates | ||
LAT-4816HCL | Recombinant Human LAT 293 Cell Lysate | +Inquiry |
LAT-4817HCL | Recombinant Human LAT 293 Cell Lysate | +Inquiry |
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Not For Human Consumption!
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