LEFTY1
-
Official Full Name
left-right determination factor 1
-
Overview
This gene encodes a member of the TGF-beta family of proteins. A similar secreted protein in mouse plays a role in left-right asymmetry determination of organ systems during development. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. [provided by RefSeq, Jul 2008] -
Synonyms
LEFTY1; left-right determination factor 1; LEFTB; LEFTYB; protein lefty-1; protein lefty-B; left-right determination factor B; left-right determination, factor B;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cynomolgus Monkey
- Human
- Mouse
- Rat
- E.coli
- HEK293
- Mammalian Cell
- Mammalian cells
- Fc
- His
- His (Fc)
- Avi
- His|GST
- N/A
- Background
- Quality Guarantee
- Case Study
- Involved Pathway
- Protein Function
- Interacting Protein
What is lefty1 protein?
Lefty1 protein is a member of the transforming growth factor beta (TGF-β) superfamily, specifically belonging to the nodal-related subfamily. It is encoded by the LEFTY1 gene in humans. Lefty1 is involved in embryonic development and plays a critical role in establishing and maintaining embryo patterning and left-right asymmetry.
Lefty1 acts as an antagonist of Nodal, a TGF-β superfamily ligand, by binding to its receptors and inhibiting its signaling pathway. This has the effect of inhibiting the expression of Nodal target genes, which are crucial for specifying the left side of the embryo during development.
What is the function of lefty1 protein?
Lefty1 functions in establishing the anterior-posterior axis and is involved in regulating cell differentiation and proliferation. It is expressed in various tissues during early embryogenesis, including the anterior visceral endoderm, node, and left lateral plate mesoderm.
Lefty1 mutations or dysregulation have been associated with several developmental abnormalities, including congenital heart defects, situs inversus, and defects in left-right asymmetry establishment.
Lefty1 related signaling pathway
Stem cell biology: Lefty1 is involved in the regulation of pluripotency and self-renewal in embryonic stem cells. Studying its signaling mechanisms can provide insights into stem cell biology and potentially aid in the development of improved protocols for the generation and differentiation of stem cells for regenerative medicine.
Cancer therapy: Understanding the role of Lefty1 in tumor biology may have implications for the development of novel cancer therapies. Targeting the Lefty1 pathway could potentially help counteract the pro-tumorigenic effects of Nodal signaling in certain cancer types.
Tissue regeneration: Manipulating the activity of Lefty1 signaling may have implications for tissue regeneration and repair. By modulating the pathway, it may be possible to promote tissue-specific differentiation and regeneration in various organs and tissues.
Lefty1 Related Diseases
- Pregnancy-related complications: Lefty1 is involved in the regulation of embryonic development and implantation. Abnormal expression of Lefty1 has been associated with pregnancy-related complications such as recurrent miscarriage and preeclampsia.
- Cardiovascular diseases: Lefty1 has been implicated in cardiovascular diseases such as heart failure and myocardial infarction. It plays a role in regulating cardiac development and function, and dysregulation of Lefty1 expression may contribute to cardiac dysfunction.
- Wound healing and tissue regeneration: Lefty1 has been found to play a role in tissue repair and regeneration processes. It may have potential applications in promoting wound healing and tissue regeneration in various medical conditions, such as skin ulcers and tissue injuries.
Biomedical Application of lefty1 Protein
- Wound healing and tissue regeneration: Lefty1 has been found to play a role in tissue repair and regeneration processes. It may have potential applications in promoting wound healing and tissue regeneration in various medical conditions, such as skin ulcers and tissue injuries.
- Immune modulation: Lefty1 has been shown to regulate immune responses and inflammatory processes. It may have therapeutic potential in immune-related disorders, such as autoimmune diseases, where balancing immune responses is crucial for disease management.
High Purity
Fig1. SDS-PAGE (LEFTY1-367H)
(Yarong Zhao, 2022)
Fig3. Characterization of sEvs and sEvLs. RT-qPCR detection of relative levels of lefty1 mRNA in cells and vesicles to characterize the loading rate of lefty1 mRNA in Ctrl, CLs, sEvs and sEvLs.
(Yajie Qian, 2023)
Fig4. Optogenetic control of gene expression in zebrafish. Quantitative analysis of the development of zebrafish embryos incubated under light or dark conditions for 30 h. The zebrafish embryos injected with GAVPOLT and UASG-TATA-GFP transcription unit were used as the controls.
LEFTY1 involved in several pathways and played different roles in them. We selected most pathways LEFTY1 participated on our site, such as Developmental Biology, Integrated Pancreatic Cancer Pathway, Regulation of signaling by NODAL, which may be useful for your reference. Also, other proteins which involved in the same pathway with LEFTY1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Developmental Biology | CRMP1;SPNA1;RHOAE;BOC;PAQR3B;SEMA3AA;PHB;EPHB4B;EGR2 |
| Integrated Pancreatic Cancer Pathway | CD82;GPRC5A;FST;PPP1R13L;RB1CC1;MST1;TFF1;TOP2A;LEFTY1 |
| Regulation of signaling by NODAL | ACVR1C;LEFTY1;TDGF1;CFC1 |
| Signaling by NODAL | TDGF1;LEFTY1;DRAP1;CFC1;FOXH1;ACVR1C;GDF1;PCSK6 |
| TGF Beta Signaling Pathway | FOXH1;RUNX3;TGFBR3;NOG;LEFTY1;FST;ENG;ZNF423;ZFP423 |
| TGF-beta signaling pathway | AMHR2;RHOAB;BMPR2;TGFB1;SMAD1;PITX2;BMPR2B;LEFTY1;ROCK2B |
LEFTY1 has several biochemical functions, for example, cytokine activity, growth factor activity, transforming growth factor beta receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LEFTY1 itself. We selected most functions LEFTY1 had, and list some proteins which have the same functions with LEFTY1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytokine activity | TGFB2;HMGB1A;C1QTNF4;IL13;CSF1A;INHBB;Fasl;THPO;ILTIFB |
| growth factor activity | TGFB1;PDGFAB;ENDOU;AREG;GRN;THBS4B;TGFB3;THPO;GDF15 |
| transforming growth factor beta receptor binding | BMP10;LFT1;NODAL;INHBB;GDF6B;MSTNA;SPAW;BMP8B;INHBC |
LEFTY1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LEFTY1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LEFTY1.
- Q&As
- Reviews
Q&As (5)
Ask a questionCombination therapies involving LEFTY1 are being investigated to enhance treatment efficacy and reduce the risk of resistance development.
Some clinical trials are exploring the therapeutic potential of LEFTY1, particularly in cancer treatment and tissue regeneration.
LEFTY1 interacts with various signaling pathways, influencing cellular processes involved in development, immune response, and disease progression.
LEFTY1 has shown potential clinical applications in various fields, including cancer research and regenerative medicine.
LEFTY1 has demonstrated the ability to influence stem cell differentiation and tissue repair, making it a potential candidate for regenerative medicine.
Customer Reviews (3)
Write a reviewThe knowledgeable and experienced support team is readily available to address any questions or concerns that researchers may have throughout their experimental journey.
Its stability and reliability warrant its inclusion in my research protocols, leading to meaningful and conclusive results.
Their prompt and effective responses help ensure smooth and efficient progress, indeed solving any problem that arises.
Ask a Question for All LEFTY1 Products
Required fields are marked with *
My Review for All LEFTY1 Products
Required fields are marked with *
