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LEFTY2

Official Full Name

left-right determination factor 2
Overview

This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. Alternate splicing of this gene results in multiple transcript variants.
Synonyms

LEFTY2; left-right determination factor 2; EBAF, endometrial bleeding associated factor (left right determination, factor A; transforming growth factor beta superfamily) , TGFB4; LEFTA; LEFTYA; transforming growth factor; beta 4 (endometrial bleeding associated factor; LEFTY A); EBAF; Endometrial bleeding associated factor (left right determination factor A transforming growth factor beta superfamily); Endometrial bleeding associated factor; Endometrial bleeding-associated factor; LEFTY 2; TGF-beta-4; protein lefty-2; protein lefty-A; left-right determination factor A; transforming growth factor beta-4; TGFB4;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rat

Source

E. coli
E.coli
HEK293
Human Cell
Mammalian Cell
Mammalian cells

Tag

C
His
Fc
His (Fc)
Avi
Myc
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	LEFTY2-799H	Recombinant Human LEFTY2, Fc tagged	Human Cell	Fc		$498 / 20 µg
Human	LEFTY2-7972H	Recombinant Human LEFTY2 protein, His-tagged	E.coli	His	Tyr245~Asp356	Inquiry
Human	LEFTY2-2779HCL	Recombinant Human LEFTY2 cell lysate	Human Cell	N/A		Inquiry
Human	LEFTY2-501H	Recombinant Human LEFTY2 protein, His-tagged	E. coli	His	24-366 aa	$319 / 25ug
Human	LEFTY2-002H	Recombinant Human LEFTY2 Protein, C-His tagged	HEK293	C-His		Inquiry
Human	LEFTY2-3161H	Recombinant Human LEFTY2 protein, His&Myc-tagged	E.coli	His&Myc	77-366aa	Inquiry
Human	LEFTY2-5129H	Recombinant Human LEFTY2 Protein (Phe78-Pro366), N-His tagged	Mammalian cells	N-His	Phe78-Pro366	Inquiry
Mouse	LEFTY2-9037M	Recombinant Mouse LEFTY2 Protein	Mammalian Cell	His		Inquiry
Mouse	Lefty2-7973M	Recombinant Mouse Lefty2 protein, His-tagged	E.coli	His	Tyr247~Asp358 (Accession # P57785)	Inquiry
Mouse	LEFTY2-5034M-B	Recombinant Mouse LEFTY2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	Lefty2-3162M	Recombinant Mouse Lefty2 protein, His&Myc-tagged	E.coli	His&Myc	78-368aa	Inquiry
Mouse	LEFTY2-5034M	Recombinant Mouse LEFTY2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	Lefty2-7974R	Recombinant Rat Lefty2 protein, His-tagged	E.coli	His	Tyr245~Asp356 (Accession # Q5UCE3)	Inquiry
Chicken	LEFTY2-6328C	Recombinant Chicken LEFTY2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
LEFTY2 Related Articles

LEFTY2 involved in several pathways and played different roles in them. We selected most pathways LEFTY2 participated on our site, such as TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with LEFTY2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
TGF-beta signaling pathway	BMP2;BAMBI;ROCK1;CUL1A;ZFYVE16;SMURF1;ACVR1L;NOG2;SMAD3A
Signaling pathways regulating pluripotency of stem cells	LIFR;BMP2;ACVR2A;ISL1;LIF;INHBB;MAPK12;STAT3;BMI1

LEFTY2 has several biochemical functions, for example, cytokine activity, growth factor activity, transforming growth factor beta receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LEFTY2 itself. We selected most functions LEFTY2 had, and list some proteins which have the same functions with LEFTY2. You can find most of the proteins on our site.

Function	Related Protein
cytokine activity	BMP15;IFNA12;IL24;BMP6;VSTM1;BMP1;FGF2;IL5;IL26
growth factor activity	EREG;EPGN;GDF6;INHBAA;Fgf15;IL8L2;PRL2C3;FGF22;GDF6B
transforming growth factor beta receptor binding	GDF11;BMP10;AMH;TGFB2;GDF3;BMP5;INHBAB;INHBA;GDF2

LEFTY2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LEFTY2 here. Most of them are supplied by our site. Hope this information will be useful for your research of LEFTY2.

MAPK8IP2; ACSS3

Fresques, T; Zazueta-Novoa, V; et al. Selective Accumulation of Germ- Line Associated Gene Products in Early Development of the Sea Star and Distinct Differences From Germ- Line Development in the Sea Urchin. DEVELOPMENTAL DYNAMICS 243:568-587(2014).

Chen, LY; Austin, E; et al. A Common Variant in the Left-Right Determination Factor 2 Gene (LEFTY2) Interacts With Advancing Age to Modify the Risk of Atrial Fibrillation: The Atherosclerosis Risk in Communities (ARIC) and Cardiovascular Health Study (CHS). CIRCULATION 128:-(2013).