Recombinant Human LEFTY2 Protein, C-His tagged
| Cat.No. : |
LEFTY2-002H |
| Product Overview : |
Recombinant Human LEFTY2 Protein with C-His tag was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
| Description : |
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. This gene is closely linked to both a related family member and a related pseudogene. This gene encodes multiple isoforms that may undergo similar proteolytic processing. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
C-His |
| Molecular Mass : |
33.7 kDa |
| AA Sequence : |
RFSQSFREVAGRFLASEASTHLLVF GMEQRLPPNSELVQAVLRLFQEPVP KAALHRHGRLSPRSAQARVTVEWLR VRDDGSNRTSLIDSRLVSVHESGWK AFDVTEAVNFWQQLSRPRQPLLLQV SVQREHLGPLASGAHKLVRFASQGA PAGLGEPQLELHTLDLRDYGAQGDC DPEAPMTEGTRCCRQEMYIDLQGMK WAKNWVLEPPGFLAYECVGTCQQPP EALAFNWPFLGPRQCIASETASLPM IVSIKEGGRTRPQVVSLPNMRVQKC SCASDGALVPRRLQPDDDDKHHHHH H |
| Endotoxin : |
< 1 EU/μg by LAL |
| Purity : |
> 90% by SDS-PAGE |
| Storage : |
Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Concentration : |
0.28 mg/mL |
| Storage Buffer : |
PBS, pH 7.4 |
| Gene Name : |
LEFTY2 left-right determination factor 2 [ Homo sapiens (human) ] |
| Official Symbol : |
LEFTY2 |
| Synonyms : |
LEFTY2; left-right determination factor 2; EBAF, endometrial bleeding associated factor (left right determination, factor A; transforming growth factor beta superfamily) , TGFB4; LEFTA; LEFTYA; transforming growth factor; beta 4 (endometrial bleeding associated factor; LEFTY A); TGF-beta-4; protein lefty-2; protein lefty-A; left-right determination factor A; transforming growth factor beta-4; endometrial bleeding-associated factor; EBAF; TGFB4; MGC46222; |
| Gene ID : |
7044 |
| mRNA Refseq : |
NM_003240 |
| Protein Refseq : |
NP_003231 |
| MIM : |
601877 |
| UniProt ID : |
O00292 |
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
