map2k4

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map2k4

Official Full Name mitogen-activated protein kinase kinase 4
Background SAPK/Erk kinase (SEK1), also known as MKK4 or Jun kinase kinase (JNKK), activates the MAP kinase homologues SAPK and JNK in response to various cellular stresses and inflamatory cytokines (1-3). Activation of SEK1 occurs through MEKK phosphorylation of se
Synonyms MAP2K4; mitogen-activated protein kinase kinase 4; SERK1; dual specificity mitogen-activated protein kinase kinase 4; JNKK1; MEK4; MKK4; PRKMK4; MEK 4; MAPKK 4; SAPK kinase 1; MAPK/ERK kinase 4; SAPK/ERK kinase 1; MAP kinase kinase 4; JNK-activated kinase
    • Species :
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human
    • Insect Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • MBP
    • SUMO
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAP2K4-105H Recombinant Human MAP2K4, His-tagged Sf9 Insect Cell His
    Human MAP2K4-17H Recombinant Human MAP2K4 Protein, GST-tagged E.coli GST
    Human MAP2K4-304H Recombinant Human MAP2K4 protein, His/MBP-tagged E.coli His/MBP
    Human MAP2K4-3115H Recombinant Human MAP2K4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human MAP2K4-33H Recombinant human biotinylated MAP2K4, His-tagged E.coli His
    Human MAP2K4-394H Recombinant Human MAP2K4 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human MAP2K4-597H Recombinant Human Mitogen-Activated Protein Kinase kinase 4, His-tagged Human His
    Human MAP2K4-8086H Recombinant Human MAP2K4 protein, His & GST-tagged E.coli His/GST
    Mouse Map2k4-1351M Recombinant Mouse Map2k4, His & GST tagged Insect Cell His/GST
    Mouse Map2k4-3923M Recombinant Mouse Map2k4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse MAP2K4-557MCL Recombinant Mouse MAP2K4 cell lysate Insect Cell N/A
    Mouse MAP2K4-641M Recombinant Mouse MAP2K4 Protein (2-397 aa), His-SUMO-tagged E.coli His/SUMO

    map2k4 involved in several pathways and played different roles in them. We selected most pathways map2k4 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with map2k4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway HSP70; MAP2K2; SRF; CDC42L; C11orf52; DUSP3; IL1R1; AKT3A; NGF; PAK2A
    ErbB signaling pathway SHC1; SHC2; CBL; CAMK2G1; PIK3R1; MAP2K2A; CBLC; ERBB3B; ERBB3A; NRAS
    Toll-like receptor signaling pathway TNF; Ifna11; TLR4; TLR8; IFNA3; MAPK14A; AKT1; MAPK12A; MAP2K4A; IRF5
    Fc epsilon RI signaling pathway FYN; GAB2; PIK3CD; NRAS; PRKCA; PIK3R1; PLCG2; RAC2; FCER1A; PLA2G4C
    TNF signaling pathway CREB3L1; PIK3R3; CASP8; TRAF5; PIK3CD; LIF; MAP3K7IP3; SOCS3; FAS; ICAM1
    GnRH signaling pathway CDC42L; MMP14A; MAP3K3; LHB; HRAS; CALM3; MAPK14A; CALM3B; CALM; ITPR1
    Epithelial cell signaling in Helicobacter pylori infection ATP6V0A4; CXCL1; ATP6V1B2; ATP6V1D; PLCG1; IKBKB; ATP6V1G2; NFKB1; MAPK8; CXCR2
    Chagas disease (American trypanosomiasis) PPP2CB; PPP2R1A; RELA; CXCL8; CCL3L1; TGFB3; TRAF6; IL6; NOS2; GNA14
    Hepatitis B PTEN; PRKCA; TP53; FASLG; CREB3L2; MAPK8; RELA; TIRAP; DDX3X; Ifna11
    Influenza A IFNA12; IFNA14; EIF2AK1; Fasl; STAT2; DDX39B; IFN-a; NLRX1; BLB1; OAS3
    HTLV-I infection MAPK8; CRTC3; NFATC2; WNT9A; STAT5B; WNT7A; WNT7B; RELB; HLA-DMA; TNFRSF13C
    Epstein-Barr virus infection MAPK11; MAP2K3; ICAM1; TRAF3; PIK3R2; CR2; SPI1; HLA-DPA1; HLA-DQB1; NFKBIA

    map2k4 has several biochemical functions, for example, ATP binding, protein binding, protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by map2k4 itself. We selected most functions map2k4 had, and list some proteins which have the same functions with map2k4. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding TAOK1; MAPK14A; MAPK1; EIF2AK2; GALK2; PRKCE; MCMDC2; SPG7; KIF20B; MET
    protein binding Ccl27a; OLFM1; TH; TSPAN12; TMEM190; C4BP; SEMA7A; SKP2; GBP5; AOC3
    protein kinase activity CDK7; NRBP1; MAP4K1; CCL3; SBK1; CCL8; PAK2A; EPHA4B; PTK2AA; EIF2AK3
    protein serine/threonine kinase activity MAPK1; MAPK11; CLK1; PAK3; STK32C; AKT1; CAMK1DB; NEK2; MAP2K2; STRC
    protein tyrosine kinase activity EGFRA; MAP2K4; TTK; DSTYK; FYN; BCR; AXL; JAK1; Aatk; KDRL

    map2k4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with map2k4 here. Most of them are supplied by our site. Hope this information will be useful for your research of map2k4.

    MAP3K1; ARRB2; MAPK8; ARRB1; CFLAR; yopP; Arrb2; TRIB1; FBP2; ALDOB; MAPK9; STX17; CYLC2; RBBP8; pi3p; npm_alk

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