MAP2K4 Protein


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Official Full Name mitogen-activated protein kinase kinase 4
Background SAPK/Erk kinase (SEK1), also known as MKK4 or Jun kinase kinase (JNKK), activates the MAP kinase homologues SAPK and JNK in response to various cellular stresses and inflamatory cytokines (1-3). Activation of SEK1 occurs through MEKK phosphorylation of se
Synonyms MAP2K4; mitogen-activated protein kinase kinase 4; SERK1; dual specificity mitogen-activated protein kinase kinase 4; JNKK1; MEK4; MKK4; PRKMK4; MEK 4; MAPKK 4; SAPK kinase 1; MAPK/ERK kinase 4; SAPK/ERK kinase 1; MAP kinase kinase 4; JNK-activated kinase;
    • Species :
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human
    • Insect (sf21)
    • Insect Cell
    • Mammalian cells
    • Sf9 Insect Cell
    • Tag :
    • Flag
    • GST
    • His
    • His (Fc)-Avi
    • MBP
    • SUMO
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAP2K4-105H Active Recombinant Human MAP2K4, His-tagged Sf9 Insect Cell His Inquiry
    Human MAP2K4-304H Recombinant Human MAP2K4 protein, His/MBP-tagged E.coli His/MBP Inquiry
    Human MAP2K4-33H Recombinant human biotinylated MAP2K4, His-tagged E.coli His Inquiry
    Human MAP2K4-597H Recombinant Human Mitogen-Activated Protein Kinase kinase 4, His-tagged Human His Inquiry
    Human MAP2K4-8086H Recombinant Human MAP2K4 protein, His & GST-tagged E.coli His/GST Inquiry
    Mouse Map2k4-1351M Recombinant Mouse Map2k4, His & GST tagged Insect Cell His/GST
    Mouse MAP2K4-557MCL Recombinant Mouse MAP2K4 cell lysate Insect Cell N/A Inquiry
    Human MAP2K4-1091HFL Recombinant Full Length Human MAP2K4 Protein, C-Flag-tagged Mammalian cells Flag Inquiry
    Human MAP2K4-1354H Recombinant Human MAP2K4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi Inquiry
    Human MAP2K4-5287HF Recombinant Full Length Human MAP2K4 Protein, GST-tagged Insect (sf21) GST Inquiry
    Human MAP2K4-17H Recombinant Human MAP2K4 Protein, GST-tagged E.coli GST Inquiry
    Human MAP2K4-3115H Recombinant Human MAP2K4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK Inquiry
    Human MAP2K4-394H Recombinant Human MAP2K4 Protein, MYC/DDK-tagged HEK293 Myc/DDK Inquiry
    Mouse Map2k4-3923M Recombinant Mouse Map2k4 Protein, Myc/DDK-tagged HEK293T Myc/DDK Inquiry
    Mouse MAP2K4-641M Recombinant Mouse MAP2K4 Protein (2-397 aa), His-SUMO-tagged E.coli His/SUMO Inquiry

    MAP2K4 involved in several pathways and played different roles in them. We selected most pathways MAP2K4 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP2K4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway FGF6B; MAPK13; HRASB; MAP4K3; MAP3K3; NLK1; TGFBR1B; CACNA2D2; CACNG6; MAP2K4
    ErbB signaling pathway HRASB; RPS6KB1; PAK3; MAP2K2B; CAMK2G; PRKCG; ELK1; STAT5A; BADB; PIK3R3
    Toll-like receptor signaling pathway MAPK12; MAP2K4; CXCL8B.3; IFNA14; TLR1LB; CD80; IL6; RIPK1L; MAPK3; NFKBIA
    Fc epsilon RI signaling pathway RAC2; NRAS; IL13; MAP2K6; FCER1A; RAC3; BTK; PIK3R3; LCP2; RAC1
    TNF signaling pathway MAP2K4; TNFRSF1A; MAGI2; BCL3; PIK3CD; PIK3CG; AKT2; MMP14; LTA; MAPK8
    Epithelial cell signaling in Helicobacter pylori infection ATP6V1G2; ATP6V0A4; ATP6V1G3; ATP6AP1; ATP6V0D2; ATP6V1D; TJP1; SRC; CXCR1; PAK1
    Chagas disease (American trypanosomiasis) SMAD3; IRAK4; IKBKG; Il2; AKT1; PIK3R1; IFNGR1; PPP2R2A; TNF; C1QB
    Hepatitis B TGFB1; IRF3; DDX58; TGFB2; IFNA1; CREB3L3; PRKCG; CASP9; FOS; BAX
    HTLV-I infection SMAD3; CD3E; HLA-DRA; CDC27; WNT16; ANAPC5; GPS2; VDAC3; NFKB1; FZD7
    Epstein-Barr virus infection HLA-DQB1; POLR2G; NFKBIA; HDAC2; TBK1; H2-Q10; CCNA2; EIF2AK3; YWHAB; CDK1

    MAP2K4 has several biochemical functions, for example, ATP binding, protein binding, protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP2K4 itself. We selected most functions MAP2K4 had, and list some proteins which have the same functions with MAP2K4. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding CLCN3; MAP3K3; SMARCA4; ATP9A; PGS1; FUK; FLT4; ABL1; DDX17; DDX5
    protein binding FER; SPATC1; NPHP3; SEC22C; BCAS2; FBXL15; IRF4; RPS6KA4; EIF4EBP1; AZIN1
    protein kinase activity VRK1; EIF2AK3; TBRG4; CDK13; CDK8; JAK2B; NTRK3A; EGFRA; MAP3K5; CAMK2G1
    protein serine/threonine kinase activity SIK2A; NEK3; MAP2K5; ADCK5; TNK2; ARAF; RIPK1; PHKG1A; STK32C; MAPK12B
    protein tyrosine kinase activity JAK2A; JAK2B; INSR; ERBB3B; SRMS; PTK2; FYNB; ZAP70; JAK1; Fert2

    MAP2K4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP2K4 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP2K4.

    MAP3K1; ARRB2; MAPK8; ARRB1; CFLAR; yopP; Arrb2; TRIB1; FBP2; ALDOB; MAPK9; STX17; CYLC2; RBBP8; pi3p; npm_alk

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