MAP2K4
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Official Full Name
mitogen-activated protein kinase kinase 4
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Overview
SAPK/Erk kinase (SEK1), also known as MKK4 or Jun kinase kinase (JNKK), activates the MAP kinase homologues SAPK and JNK in response to various cellular stresses and inflamatory cytokines (1-3). Activation of SEK1 occurs through MEKK phosphorylation of se -
Synonyms
MAP2K4; mitogen-activated protein kinase kinase 4; SERK1; dual specificity mitogen-activated protein kinase kinase 4; JNKK1; MEK4; MKK4; PRKMK4; MEK 4; MAPKK 4; SAPK kinase 1; MAPK/ERK kinase 4; SAPK/ERK kinase 1; MAP kinase kinase 4; JNK-activated kinase;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
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- GST
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- His|GST
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- Myc
- DDK
- Myc|DDK
- N/A
- N
- C
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
- MAP2K4 Related Signal Pathway
MAP2K4 involved in several pathways and played different roles in them. We selected most pathways MAP2K4 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP2K4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | FGF1A;MAP4K4;FGFR2;ARR3A;PRKACG;FLNA;CACNA1D;MAP4K1;MAPK8B |
| ErbB signaling pathway | RPS6KB1;SOS1;STAT5A;GSK3AA;ERBB3A;NCK2A;PIK3R5;HBEGFB;RAF1 |
| Toll-like receptor signaling pathway | RELA;MAP2K2;IFNA6;CCL3;RIPK1;IFNA10;IRAK1;MAPK12;IFNA17 |
| Fc epsilon RI signaling pathway | PIK3CB;MAPK1;LCP2;PIK3CA;PLA2G4F;IL5;SYK;INPP5D;PIK3R2 |
| TNF signaling pathway | NFKBIA;TNFAIP3;CCL20;DNM1L;Casp3;MAP3K7IP3;LIF;TRADD;PIK3R5 |
| GnRH signaling pathway | LHBETA1;GNRHR1;GNRHR2;GNA15.1;RAF1B;MAPK12;PLA2G4A;GNRHR;MMP14A |
| Epithelial cell signaling in Helicobacter pylori infection | IKBKB;ATP6V1C2;MAPK12;ATP6V1F;CDC42;MAP3K14;MAPK10;MAPK8;PTPN11 |
| Chagas disease (American trypanosomiasis) | PPP2R1B;IRAK1;ACE;IFNB1;RELA;CCL3L3;MAP2K4;TRAF6;CD247 |
| Hepatitis B | IFNA14;IFIH1;IFNA1;CCNA1;Ifna15;RELA;SMAD4;MYD88;BIRC5 |
| Influenza A | IFNA14;IRF9;PYCARD;IFNA3;IFN-a;IFNG;DNAJC3;CASP9;IFNA1 |
| HTLV-I infection | SLC2A1;WNT4;FZD8;SMAD3;FZD5;BAX;IL2RG;PIK3CG;ANAPC5 |
| Epstein-Barr virus infection | HDAC1;IKBKB;POLR2I;PSMD2;IFNG;ENTPD3;POLR2G;BCL2;CD40 |
MAP2K4 has several biochemical functions, for example, ATP binding, protein binding, protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP2K4 itself. We selected most functions MAP2K4 had, and list some proteins which have the same functions with MAP2K4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | IGF1R;UBE2NB;AK1;ATP11A;HSPA12A;ACTB1;TAF1;KIF16B;CAMKK1B |
| protein binding | RASSF5;LAMP2;HCLS1;HSCB;MEF2C;PBRM1;EP300;AMFR;FOXK2 |
| protein kinase activity | ANKK1;NPR1;GM711;PPP1R9B;PRKCBB;MKNK2B;PRKD2;STK35L;TRIO |
| protein serine/threonine kinase activity | MAP3K10;PHKG1B;ARAF;CAMK1DA;CSNK1G3;NEK10;PRKACBB;PRPF4B;MAP3K9 |
| protein tyrosine kinase activity | KDRL;EPHB3A;CLK3;FGFR1OP;FYNB;YES1;ZAP70;Aatk;DYRK3 |
MAP2K4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP2K4 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP2K4.
MAP3K1; ARRB2; MAPK8; ARRB1; CFLAR; yopP; Arrb2; TRIB1; FBP2; ALDOB; MAPK9; STX17; CYLC2; RBBP8; pi3p; npm_alk
Research Area
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Customer Reviews (3)
Write a reviewGood value, high quality.
Pure product, no issues.
Reliable, worked as described.
Q&As (7)
Ask a questionTargeting MAP2K4 may provide therapeutic benefits in cancer, modulating cell survival and response to stress.
MAP2K4 helps cells respond to stress, modulating survival and death pathways.
Dysregulation of MAP2K4 has been linked to cancer, affecting cell growth and resistance to apoptosis.
It phosphorylates and activates JNK and p38, transmitting signals in response to stress.
Its activity is regulated by phosphorylation and interaction with other signaling proteins.
MAP2K4 is involved in processes like cell growth, apoptosis, and stress response.
MAP2K4 is a kinase that plays a critical role in activating the JNK and p38 MAPK signaling pathways.
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