MAP2K4

  • Official Full Name

    mitogen-activated protein kinase kinase 4

  • Overview

    SAPK/Erk kinase (SEK1), also known as MKK4 or Jun kinase kinase (JNKK), activates the MAP kinase homologues SAPK and JNK in response to various cellular stresses and inflamatory cytokines (1-3). Activation of SEK1 occurs through MEKK phosphorylation of se
  • Synonyms

    MAP2K4; mitogen-activated protein kinase kinase 4; SERK1; dual specificity mitogen-activated protein kinase kinase 4; JNKK1; MEK4; MKK4; PRKMK4; MEK 4; MAPKK 4; SAPK kinase 1; MAPK/ERK kinase 4; SAPK/ERK kinase 1; MAP kinase kinase 4; JNK-activated kinase;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Cell & Tissue Lysates
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • Insect (sf21)
  • Insect Cell
  • Insect Cells
  • Mammalian cells
  • Sf9 Insect Cell
  • Yeast
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • His|MBP
  • His|SUMO
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • C
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MAP2K4-105H Active Recombinant Human MAP2K4, His-tagged Sf9 Insect Cell His
Human MAP2K4-597H Recombinant Human Mitogen-Activated Protein Kinase kinase 4, His-tagged Human His
Human MAP2K4-33H Recombinant human biotinylated MAP2K4, His-tagged E.coli His
Human MAP2K4-304H Recombinant Human MAP2K4 protein, His/MBP-tagged E.coli His/MBP 218-362 aa
Human MAP2K4-8086H Recombinant Human MAP2K4 protein, His & GST-tagged E.coli His/GST Val137~Ser394 (Accession # P45985)
Human MAP2K4-394H Recombinant Human MAP2K4 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human MAP2K4-17H Recombinant Human MAP2K4 Protein, GST-tagged E.coli GST
Human MAP2K4-1354H Recombinant Human MAP2K4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human MAP2K4-5287HF Active Recombinant Full Length Human MAP2K4 Protein, GST-tagged Insect (sf21) GST 1-399
Human MAP2K4-3332H Recombinant Human MAP2K4 protein, His&Myc-tagged E.coli N-His&C-Myc 2-399aa
Human MAP2K4-3115H Recombinant Human MAP2K4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MAP2K4-1091HFL Recombinant Full Length Human MAP2K4 Protein, C-Flag-tagged Mammalian cells Flag
Human MAP2K4-1354H-B Recombinant Human MAP2K4 Protein Pre-coupled Magnetic Beads HEK293
Human MAP2K4-643H Recombinant Human MAP2K4 protein, His-GST-tagged Yeast N-His-GST 2-399aa
Mouse MAP2K4-145M Active Recombinant Mouse MAP2K4(34-end) Protein, N-GST-tagged E.coli GST 34-end
Mouse MAP2K4-146M Unactive Recombinant Mouse MAP2K4(35-397) Protein, N-GST-tagged E.coli GST 35-397 aa
Mouse Map2k4-1351M Recombinant Mouse Map2k4 protein(Ala2-Asp397), His&GST-tagged Insect Cells N-His&GST Ala2-Asp397
Mouse MAP2K4-557MCL Recombinant Mouse MAP2K4 cell lysate Insect Cell N/A
Mouse MAP2K4-641M Recombinant Mouse MAP2K4 Protein (2-397 aa), His-SUMO-tagged E.coli His/SUMO 2-397 aa
Mouse Map2k4-3923M Recombinant Mouse Map2k4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • MAP2K4 Related Signal Pathway

MAP2K4 involved in several pathways and played different roles in them. We selected most pathways MAP2K4 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP2K4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayFGF1A;MAP4K4;FGFR2;ARR3A;PRKACG;FLNA;CACNA1D;MAP4K1;MAPK8B
ErbB signaling pathwayRPS6KB1;SOS1;STAT5A;GSK3AA;ERBB3A;NCK2A;PIK3R5;HBEGFB;RAF1
Toll-like receptor signaling pathwayRELA;MAP2K2;IFNA6;CCL3;RIPK1;IFNA10;IRAK1;MAPK12;IFNA17
Fc epsilon RI signaling pathwayPIK3CB;MAPK1;LCP2;PIK3CA;PLA2G4F;IL5;SYK;INPP5D;PIK3R2
TNF signaling pathwayNFKBIA;TNFAIP3;CCL20;DNM1L;Casp3;MAP3K7IP3;LIF;TRADD;PIK3R5
GnRH signaling pathwayLHBETA1;GNRHR1;GNRHR2;GNA15.1;RAF1B;MAPK12;PLA2G4A;GNRHR;MMP14A
Epithelial cell signaling in Helicobacter pylori infectionIKBKB;ATP6V1C2;MAPK12;ATP6V1F;CDC42;MAP3K14;MAPK10;MAPK8;PTPN11
Chagas disease (American trypanosomiasis)PPP2R1B;IRAK1;ACE;IFNB1;RELA;CCL3L3;MAP2K4;TRAF6;CD247
Hepatitis BIFNA14;IFIH1;IFNA1;CCNA1;Ifna15;RELA;SMAD4;MYD88;BIRC5
Influenza AIFNA14;IRF9;PYCARD;IFNA3;IFN-a;IFNG;DNAJC3;CASP9;IFNA1
HTLV-I infectionSLC2A1;WNT4;FZD8;SMAD3;FZD5;BAX;IL2RG;PIK3CG;ANAPC5
Epstein-Barr virus infectionHDAC1;IKBKB;POLR2I;PSMD2;IFNG;ENTPD3;POLR2G;BCL2;CD40

MAP2K4 has several biochemical functions, for example, ATP binding, protein binding, protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP2K4 itself. We selected most functions MAP2K4 had, and list some proteins which have the same functions with MAP2K4. You can find most of the proteins on our site.

Function Related Protein
ATP bindingIGF1R;UBE2NB;AK1;ATP11A;HSPA12A;ACTB1;TAF1;KIF16B;CAMKK1B
protein bindingRASSF5;LAMP2;HCLS1;HSCB;MEF2C;PBRM1;EP300;AMFR;FOXK2
protein kinase activityANKK1;NPR1;GM711;PPP1R9B;PRKCBB;MKNK2B;PRKD2;STK35L;TRIO
protein serine/threonine kinase activityMAP3K10;PHKG1B;ARAF;CAMK1DA;CSNK1G3;NEK10;PRKACBB;PRPF4B;MAP3K9
protein tyrosine kinase activityKDRL;EPHB3A;CLK3;FGFR1OP;FYNB;YES1;ZAP70;Aatk;DYRK3

MAP2K4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP2K4 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP2K4.

MAP3K1; ARRB2; MAPK8; ARRB1; CFLAR; yopP; Arrb2; TRIB1; FBP2; ALDOB; MAPK9; STX17; CYLC2; RBBP8; pi3p; npm_alk

  • Q&As
  • Reviews

Q&As (7)

Ask a question
Are there existing or potential therapeutic strategies targeting MAP2K4? 06/12/2022

Targeting MAP2K4 may provide therapeutic benefits in cancer, modulating cell survival and response to stress.

What role does MAP2K4 play in cellular stress response? 03/24/2022

MAP2K4 helps cells respond to stress, modulating survival and death pathways.

How is MAP2K4 implicated in cancer development and progression? 04/28/2020

Dysregulation of MAP2K4 has been linked to cancer, affecting cell growth and resistance to apoptosis.

How does MAP2K4 contribute to the JNK and p38 MAPK pathways? 02/25/2020

It phosphorylates and activates JNK and p38, transmitting signals in response to stress.

How is the activity of MAP2K4 regulated within cells? 10/29/2019

Its activity is regulated by phosphorylation and interaction with other signaling proteins.

In which cellular processes is MAP2K4 involved? 10/07/2019

MAP2K4 is involved in processes like cell growth, apoptosis, and stress response.

What is the primary biological function of MAP2K4 in cellular signaling? 11/23/2018

MAP2K4 is a kinase that plays a critical role in activating the JNK and p38 MAPK signaling pathways.

Customer Reviews (3)

Write a review
Reviews
10/25/2021

    Good value, high quality.

    04/03/2021

      Pure product, no issues.

      03/13/2021

        Reliable, worked as described.

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