mdm2
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  • Official Full Name
  • MDM2 oncogene, E3 ubiquitin protein ligase
  • Background
  • This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]
  • Synonyms
  • MDM2; MDM2 oncogene, E3 ubiquitin protein ligase; HDMX; hdm2; ACTFS; E3 ubiquitin-protein ligase Mdm2; oncoprotein Mdm2; Mdm2, p53 E3 ubiquitin protein ligase homolog; double minute 2, human homolog of; p53-binding protein; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein;
Cat.#:MDM2-651MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse MDM2 Protein (1-489 aa), His-tagged
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Cat.#:MDM2-568HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MDM2 Protein, His-tagged
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Cat.#:MDM2-105HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MDM2, His-tagged
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Cat.#:MDM2-1063HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mdm2 p53 Binding Protein Homolog, GST-tagged
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Cat.#:MDM2-1064HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mdm2 p53 Binding Protein Homolog, His-tagged
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Cat.#:MDM2-1065HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human MDM2, GST-tagged
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Cat.#:MDM2-110HTag:His6-HA-SUMO
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human MDM2, His6-HA-SUMO-tagged
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Cat.#:MDM2-134HTag:T7/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MDM2 protein, T7/His-tagged
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Cat.#:MDM2-1518HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinent Human MDM2 protein
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Cat.#:MDM2-2319HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MDM2
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Cat.#:MDM2-2320HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MDM2, GST-tagged
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Cat.#:MDM2-29009THTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human MDM2
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Cat.#:MDM2-29756THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MDM2, His-tagged
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Cat.#:MDM2-306HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human MDM2
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Cat.#:MDM2-350HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant human MDM2, His-tagged
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Cat.#:MDM2-4858HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mdm2 P53 Binding Protein Homolog (Mouse), GST-tagged
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Cat.#:MDM2-6982HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MDM2, GST-tagged
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Cat.#:MDM2-9667MTag:His
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse Mdm2 Protein, His-tagged
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Cat.#:MDM2-2711RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey MDM2 Protein, His-tagged
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Cat.#:MDM2-4264CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MDM2
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Cat.#:MDM2-8944ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MDM2
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Cat.#:MDM2-4404HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MDM2 293 Cell Lysate
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Involved Pathway

MDM2 involved in several pathways and played different roles in them. We selected most pathways MDM2 participated on our site, such as FoxO signaling pathway, Cell cycle, p signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MDM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
FoxO signaling pathway
INS1; PIK3CB; CCND2; SGK2B; SMAD3A; PRKAG2A; MAPK3; MAPK13; CDKN2B; SKP2
Cell cycle
TUBB4A; WEE1; NEK6; PMF1; THRSP; SETA; CDK2; CCND2; MAPRE1B; TUBG1
p signaling pathway
SIAH1A; BAI1; CCND1; THBS1; CYCS; CCNG2; CDK1; RPRM; SIAH1; RRM2B
Ubiquitin mediated proteolysis
TCEB1; PRPF19; KLHL9; CDC34; KEAP1B; FBXW7; FBXW8; UBE2E1; FZR1A; SOCS1
Endocytosis
VPS35; HLA-B; RAB11FIP1; SMURF1; TRAF6; TGFB3; ERBB4A; RAB11B; IL2RA; CXCR4
PIK-Akt signaling pathway
PPP2R5E; PIK3R1; IFNA17; ITGA4; PDGFA; HSP90AB1; VEGFC; MTCP1; PDGFRA; GNG10
Thyroid hormone signaling pathway
PLCZ1; MED12L; SLC16A10; MED14; PRKCA; NOTCH1; PIK3CA; PFKP; HDAC2; HDAC3
Epstein-Barr virus infection
PRKACG; HSPA6; NFKBIB; PSMD3; PIK3CA; PSMC4; TYK2; PIK3R1; POLR3GL; POLR1D
Pathways in cancer
ARNT; HIF1A; PIK3R2; SLC2A1; MSH6; GSTP1; WNT7A; WNT11; PLCB4; PTGER3
Transcriptional misregulation in cancer
BIRC3; HIST1H3D; NTRK1; GZMB; WHSC1; PPARG; CEBPE; PAX7; BMI1; H3F3B
Viral carcinogenesis
HIST2H4A; CCND2; HDAC3; TBP; H2-Q10; HIST1H2BH; PIK3CB; C3; HIST1H2BG; IRF3
Proteoglycans in cancer
ITPR3; PTK2; ACTG1; PLCG1; Fasl; PLAUR; PIK3CA; IGF2; IGF1; FGFR1
MicroRNAs in cancer
NOTCH2; MMP16; MAPK1; PRKCG; EZH2; HRAS; BMPR2; CCND2; PIK3R2; BCL2
Glioma
MAPK3; MAPK1; SHC4; AKT1; PDGFRB; CALML3; PLCG1; MAP2K2; PIK3CG; CAMK2G
Prostate cancer
SOS1; RB1; FOXO1; PIK3R1; CREB3L3; CREB5; BRAF; ACTL6B; EP300; RELA
Melanoma
PDGFC; PDGFD; BRAF; IGF1R; FGF6; CCND1; MAPK1; FGF11; FGF20; FGF21
Bladder cancer
MMP9; MMP2; MAPK1; IL-8; MAPK3; TYMP; SRC; CDK4; ARAF; FGFR3
Chronic myeloid leukemia
CDK6; TP53; CCND1; MAP2K1; PIK3R2; AKT2; TGFBR1; RELA; CBLC; KRAS

Protein Function

MDM2 has several biochemical functions, for example, enzyme binding, identical protein binding, ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MDM2 itself. We selected most functions MDM2 had, and list some proteins which have the same functions with MDM2. You can find most of the proteins on our site.
Function
Related Protein
Function enzyme binding
Related Protein RCOR2; UBE2L3; CYP1A1; NOTCH1; STUB1; APP; SORT1; PRKCD; GSTM7; UGT1A2
Function identical protein binding
Related Protein HOOK1; MDM2; AGXT2L2; JMJD6; PFKM; STXBP1; SH3GL3; S100A1; P2RX6; TPCN2
Function ligase activity
Related Protein RNF13; RTCB; RNF43; LTN1; RANBP2; NSMCE1; UHRF1; HECTD2; RNF180; DTX3L
Function p53 binding
Related Protein CREBBP; DAXX; BRD7; MSX1; ZFP385C; ANKRD1; TRP63; ZMAT4; SIRT1; CDKN2AIP
Function protein binding
Related Protein EYA2; NTN1; GTF2H1; CAPG; COMT; HELZ2; CD274; NRADD; RBBP4; POGZ
Function scaffold protein binding
Related Protein CHRNA7; NLGN4Y; GRIN2A; GRID2; CASP8; NLGN3; KCNH2; CRIPT; PARK7; KCNQ1
Function ubiquitin protein ligase activity
Related Protein RNF19B; MDM2; C18orf25; XIAP; SIAH1; MED23; FBXW11; RNF144A; RNF13; TRIM72
Function ubiquitin protein ligase binding
Related Protein LC3; UQCRC1; UBE2V2; BCL2; DERL1; WFS1; SCN5A; GPR19; YWHAE; PRKACB
Function ubiquitin-protein transferase activity
Related Protein MUL1A; ZER1; TNFAIP3; RNF130; RNF43; NEDD4L; RNF13; UBE2M; ZNRF3; MYLIP
Function zinc ion binding
Related Protein ZDHHC8B; GATA5; TRIM35-22; TEX13A; ESRRGB; ENPEP; MGRN1A; MMP9; BTR30; ZNF331

Interacting Protein

MDM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MDM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MDM2.
TP53

MDM2 Related Articles

Ruiz, C; Li, JL; et al. Limited genomic heterogeneity of circulating melanoma cells in advanced stage patients. PHYSICAL BIOLOGY 12:-(2015).
Herting, F; Herter, S; et al. Combination of the Glycoengineered Type II CD20 Antibody Obinutuzumab (GA101) and the MDM2 Selective Antagonist RG7388 Results in Superior Anti-Tumor Activity. BLOOD 124:-(2014).