MDM2

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MDM2

Official Full Name MDM2 oncogene, E3 ubiquitin protein ligase
Background This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]
Synonyms MDM2; MDM2 oncogene, E3 ubiquitin protein ligase; HDMX; hdm2; ACTFS; E3 ubiquitin-protein ligase Mdm2; oncoprotein Mdm2; Mdm2, p53 E3 ubiquitin protein ligase homolog; double minute 2, human homolog of; p53-binding protein; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • Human
    • Insect Cell
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • GST
    • His
    • HA
    • SUMO
    • N/A
    • T7
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MDM2-105H Recombinant Human MDM2, His-tagged E.coli His
    Human MDM2-1063H Recombinant Human Mdm2 p53 Binding Protein Homolog, GST-tagged Human GST
    Human MDM2-1064H Recombinant Human Mdm2 p53 Binding Protein Homolog, His-tagged Human His
    Human MDM2-1065H Recombinant Human MDM2, GST-tagged Wheat Germ GST
    Human MDM2-110H Recombinant Human MDM2, His6-HA-SUMO-tagged E.coli His/HA/SUMO
    Human MDM2-134H Recombinant Human MDM2 protein, T7/His-tagged E.coli T7/His
    Human MDM2-1518H Recombinant Human MDM2 protein E.coli N/A
    Human MDM2-2319H Recombinant Human MDM2 E.coli N/A
    Human MDM2-2320H Recombinant Human MDM2, GST-tagged E.coli GST
    Human MDM2-29009TH Recombinant Human MDM2 Insect Cell N/A
    Human MDM2-29756TH Recombinant Human MDM2, His-tagged E.coli His
    Human MDM2-306H Recombinant Human MDM2 Mammalian Cell His
    Human MDM2-350H Recombinant human MDM2, His-tagged E.coli His
    Human MDM2-4404HCL Recombinant Human MDM2 293 Cell Lysate HEK293 N/A
    Human MDM2-4858H Recombinant Human Mdm2 P53 Binding Protein Homolog (Mouse), GST-tagged E.coli GST
    Human MDM2-568H Recombinant Human MDM2 Protein, His-tagged E. coli His
    Human MDM2-6982H Recombinant Human MDM2, GST-tagged E.coli GST
    Mouse MDM2-651M Recombinant Mouse MDM2 Protein (1-489 aa), His-tagged E.coli His
    Mouse MDM2-9667M Recombinant Mouse Mdm2 Protein, His-tagged Yeast His
    Rhesus Macaque MDM2-2711R Recombinant Rhesus monkey MDM2 Protein, His-tagged Mammalian Cell His
    Chicken MDM2-4264C Recombinant Chicken MDM2 Mammalian Cell His
    Zebrafish MDM2-8944Z Recombinant Zebrafish MDM2 Mammalian Cell His

    MDM2 involved in several pathways and played different roles in them. We selected most pathways MDM2 participated on our site, such as FoxO signaling pathway, Cell cycle, p signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MDM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    FoxO signaling pathway MAPK3; SMAD3; KRAS; MAPK14B; RAF1B; PDPK1B; TGFB1; PIK3R1; GADD45B; MAPK8
    Cell cycle CENPW; DPF1; AURKB; CDKN2C; TOP2A; TMEM188; SET; CUL1A; CKAP5; SKP2
    p signaling pathway CCNE1; FAS; GADD45BB; CASP8; CCNB2; PTENB; APAF1; BAI1; CD82A; CCND2A
    Ubiquitin mediated proteolysis ITCHA; UBE2K; RNF7; ERCC8; CUL3B; UBE2D4; UBE2N; FBXW8; UBE2B; KEAP1
    Endocytosis IGF2R; RAB11FIP1; ARAP1; PSD4; IGF1RB; PLD1; SMAP2; GIT2B; CLINT1A; STAM
    PIK-Akt signaling pathway Gh; PPP2R2B; PDPK1; GNG3; MCL1; PIK3CB; TSC2; FGF8; THBS3; MLST8
    Thyroid hormone signaling pathway KAT2A; MED17; GSK3B; ATP1B4; WNT4; GATA4; PFKFB2; SRC; ATP1A4; PLCD4
    Epstein-Barr virus infection PSMD3; SPN; HSPA1B; GTF2E1; CSNK2A2; RAN; TBPL1; HLA-F; POLR3F; YWHAZ
    Pathways in cancer FOS; RAD51; AXIN1; HDAC1; PTGER2; LPAR6; LAMA1; BMP4; VEGFC; EGLN2
    Transcriptional misregulation in cancer TFE3; KDM6A; H3F3B; NFKBIZ; CEBPE; IGF1; ZBTB17; PTK2; PAX7; PDGFA
    Viral carcinogenesis BAK1; RAC1; CCND2; STAT5A; TRAF5; PRKACB; DNAJA3; PIK3CD; TRAF3; PKM
    Proteoglycans in cancer RPS6KB2; NANOG; MAP2K2; PTPN11; TIMP3; SRC; PRKCG; ELK1; HSPG2; FZD9
    MicroRNAs in cancer DNMT3B; SOX4; NOTCH2; MMP9; ABCB1A; EZH2; CDC25A; FSCN1; ZEB2; TPM1
    Glioma CALML3; MAP2K2; ARAF; CCND1; AKT2; PIK3R2; NRAS; PIK3CD; PIK3CB; CALM1
    Prostate cancer ARAF; CREB5; NKX3; SMARCC2; Pdgfa&Pdgfb; PDGFRA; IKBKG; PIK3CD; INS2; INS
    Melanoma FGF13; FGF5; RB1; AKT1; FGF22; MET; IGF1R; TRP53; FGF3; PIK3R2
    Bladder cancer SRC; CDK4; MAPK1; ERBB2; KRAS; THBS1; RPS6KA5; ARAF; MDM2; RASSF1
    Chronic myeloid leukemia AKT2; ABL1; TRP53; CTBP2; RUNX1; PTPN11; RB1; MECOM; SOS1; TP53

    MDM2 has several biochemical functions, for example, enzyme binding, identical protein binding, ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MDM2 itself. We selected most functions MDM2 had, and list some proteins which have the same functions with MDM2. You can find most of the proteins on our site.

    Function Related Protein
    enzyme binding NOS1; BRCA1; A2M; LAMP1; UBE2I; VAPB; PPARG; HMOX1; MAP2K7; UGT1A3
    identical protein binding BAG2; MTSS1; C10orf88; PCNA; E2F7; APIP; Serpina1c; STIM1; SH2B2; PIK3AP1
    ligase activity UBE2D1A; ZFP91; CDC34B; CBL; TRIM23; TRIM38; RAG1; RNF4; UBE2CBP; NHLRC1
    p53 binding AAAS; SMARCB1; MSX1; CDKN2AIP; GATA1; RCHY1; TP53RK; SMYD2; PLK3; CDKN2A
    protein binding NDUFB10; STAC; TRIM27; MAPK6; VHLL; SOX7; SEC61B; LYRM2; TNPO3; ARAF
    scaffold protein binding HOMER1; LRP4; SHANK3; GRIN2A; CACNA1H; P2RY1; SRC; NLRP1; NLGN1; CHUK
    ubiquitin protein ligase activity RNF144AA; HECW1; AMFR; RNF24; HACE1; RNF220; NEDD4L; RNF121; RNF175; UBR5
    ubiquitin protein ligase binding USP2; MC1R; EGR2; DNM1L; HSPA8; MID1; YWHAE; BAG4; GABARAP; UCHL1
    ubiquitin-protein transferase activity FBXO7; UBE2W; PDZRN3; PDZRN3B; RNF4; ZNRF3; RNF20; SMURF1; SMURF2; RNF139
    zinc ion binding TRIM48; CTCF; RBM20; TRPS1; RNF2; ZDHHC4; MARCH6; ZCCHC6; PCGF5B; ZRANB1B

    MDM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MDM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MDM2.

    TP53

    Ruiz, C; Li, JL; et al. Limited genomic heterogeneity of circulating melanoma cells in advanced stage patients. PHYSICAL BIOLOGY 12:-(2015).
    Herting, F; Herter, S; et al. Combination of the Glycoengineered Type II CD20 Antibody Obinutuzumab (GA101) and the MDM2 Selective Antagonist RG7388 Results in Superior Anti-Tumor Activity. BLOOD 124:-(2014).

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