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  • Official Full Name

    MDM2 oncogene, E3 ubiquitin protein ligase

  • Overview

    This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]
  • Synonyms

    MDM2; MDM2 oncogene, E3 ubiquitin protein ligase; HDMX; hdm2; ACTFS; E3 ubiquitin-protein ligase Mdm2; oncoprotein Mdm2; Mdm2, p53 E3 ubiquitin protein ligase homolog; double minute 2, human homolog of; p53-binding protein; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • Human
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • His|HA|SUMO
  • N/A
  • N
  • No tag
  • T7|His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MDM2-2320H Active Recombinant Human MDM2, GST-tagged E.coli GST
Human MDM2-105H Active Recombinant Human MDM2, His-tagged E.coli His
Human MDM2-2319H Active Recombinant Human MDM2 E.coli N/A
Human MDM2-350H Recombinant human MDM2, His-tagged E.coli His
Human MDM2-4858H Recombinant Human Mdm2 P53 Binding Protein Homolog (Mouse), GST-tagged E.coli GST
Human MDM2-1064H Recombinant Human Mdm2 p53 Binding Protein Homolog, His-tagged Human His
Human MDM2-6982H Recombinant Human MDM2, GST-tagged E.coli GST 202 aa-end
Human MDM2-29756TH Recombinant Human MDM2, His-tagged E.coli His
Human MDM2-1063H Recombinant Human Mdm2 p53 Binding Protein Homolog, GST-tagged Human GST
Human MDM2-1065H Recombinant Human MDM2, GST-tagged Wheat Germ GST
Human MDM2-1518H Recombinant Human MDM2 protein E.coli N/A
Human MDM2-134H Recombinant Human MDM2 protein, T7/His-tagged E.coli T7/His
Human MDM2-306H Recombinant Human MDM2 Mammalian Cell His
Human MDM2-110H Recombinant Human MDM2, His6-HA-SUMO-tagged E.coli His/HA/SUMO
Human MDM2-29009TH Recombinant Human MDM2 Insect Cell N/A 496 amino acids
Human MDM2-4404HCL Recombinant Human MDM2 293 Cell Lysate HEK293 N/A
Human MDM2-568H Recombinant Human MDM2 Protein, His-tagged E.coli His Met1~Pro218
Human MDM2-0426H Recombinant Human MDM2 Protein (S17-N111), Tag Free E.coli No tag S17-N111
Human MDM2-4527H Recombinant Human MDM2 Protein (Asn3-Pro491), N-His tagged E.coli N-His Asn3-Pro491
Human MDM2-6976HF Recombinant Full Length Human MDM2 Protein, GST-tagged In Vitro Cell Free System GST 491 amino acids
Human MDM236000H Recombinant Human Mdm2 (7-125) Protein
Human MDM2-3449H Recombinant Human MDM2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human MDM2-3449H-B Recombinant Human MDM2 Protein Pre-coupled Magnetic Beads HEK293
Human MDM2-0427H Recombinant Human MDM2 Protein (S17-N111), His tagged E.coli His S17-N111
Human MDM230829H Recombinant Human Mdm2 (11-125) Protein
Human MDM225650H Recombinant Human Mdm2 (1-125) Protein
Human MDM227372H Recombinant Human Mdm2 (17-125) Protein
Human MDM2-2814H Recombinant Human MDM2 protein(31-260 aa), C-His-tagged E.coli C-His 31-260 aa
Mouse MDM2-9667M Recombinant Mouse Mdm2 Protein, His-tagged Yeast His 1-489aa
Mouse MDM2-651M Recombinant Mouse MDM2 Protein (1-489 aa), His-tagged E.coli His 1-489 aa
Mouse Mdm2-1771M Recombinant Mouse Mdm2 Protein, His-tagged E.coli N-His Met1-Asn310
Rhesus Macaque MDM2-2711R Recombinant Rhesus monkey MDM2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque MDM2-2531R Recombinant Rhesus Macaque MDM2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque MDM2-2531R-B Recombinant Rhesus Macaque MDM2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish MDM2-8944Z Recombinant Zebrafish MDM2 Mammalian Cell His
Chicken MDM2-4264C Recombinant Chicken MDM2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • MDM2 Related Signal Pathway

MDM2 involved in several pathways and played different roles in them. We selected most pathways MDM2 participated on our site, such as FoxO signaling pathway, Cell cycle, p signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MDM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
p signaling pathwayMDM2;CCNG2;CCNE2;CCNB3;CASP3A;RFWD2;SIAH2L;CD82B;MDM4
Ubiquitin mediated proteolysisBIRC3;NEDD4;MDM2;UBE2D1A;UBE2E1;UBE2R2;ANAPC4;ERCC8;CDC16
PIK-Akt signaling pathwayPIK3R1;CD19;IFNAR1;PHLPP2;GNG13;ITGA1;YWHAH;HSP90B1;GNG2
Thyroid hormone signaling pathwayRCAN1;HRAS;PIK3R5;MTOR;PLCB4;AKT1;MAPK3;ATP1A3;PLCD4
Epstein-Barr virus infectionPSMD1;HSPB1;HDAC1;PSMD8;MAP3K14;XPO1;PLCG1;CD38;VIM
Transcriptional misregulation in cancerMLLT1;REL;PAX7;JMJD1C;HOXA9;CCNT1;EWSR1;FLT3;HIST1H3G
Proteoglycans in cancerERBB3;WNT2B;PIK3CG;ITGB1;WNT11;DDX5;CAMK2B;FAS;Fasl
Bladder cancerE2F3;ERBB2;TRP53;TP53;DAPK1;SRC;FGFR3;MMP2;RB1
Chronic myeloid leukemiaAKT1;CBL;CBLC;GAB2;PIK3CG;GRB2;IKBKB;PTPN11;KRAS

MDM2 has several biochemical functions, for example, enzyme binding, identical protein binding, ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MDM2 itself. We selected most functions MDM2 had, and list some proteins which have the same functions with MDM2. You can find most of the proteins on our site.

Function Related Protein
enzyme bindingCD40;ADORA2A;EHHADH;GOT2;C6orf211;CYP2A6;ATXN10;CBX1;UGT1A1
identical protein bindingHGF;CCDC91;KCNRG;HOMER1;GLUL;CHMP4B;CLDN8;IMPA1;AMELX
ligase activityGLULA;RBCK1;MSL2;TRIM5;CDC34A;RNF144B;TRIM39;TRIM2;RNF6
scaffold protein bindingCASP8;SHANK1;HOMER1;KCNA5;LRP4;KCNQ1;NOS3;CACNA1G;CAV2
ubiquitin protein ligase activityBFAR;MED24;RNF149;ARIH2;XIAP;UBE2N;MARCH1;CBLC;RNF126
ubiquitin protein ligase bindingUBE2J2;CUL9;UBE2Z;ASB4;UBE2S;CUL4B;RNF20;BAG4;DAXX
ubiquitin-protein transferase activityFBXO40.1;RNF130;RNF217;UBR1;UBE2C;TRAF4A;UHRF1;RCHY1;TRIM62
zinc ion bindingNR2E1;LHX9;BLVRA;LANCL1;ZNF276;ADAMTSL1;SIRT3;ZNF75D;NR4A2

MDM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MDM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MDM2.


Research Area

Related articles

Ruiz, C; Li, JL; et al. Limited genomic heterogeneity of circulating melanoma cells in advanced stage patients. PHYSICAL BIOLOGY 12:-(2015).
Herting, F; Herter, S; et al. Combination of the Glycoengineered Type II CD20 Antibody Obinutuzumab (GA101) and the MDM2 Selective Antagonist RG7388 Results in Superior Anti-Tumor Activity. BLOOD 124:-(2014).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
How does MDM2 regulate the tumor suppressor protein p53? 11/20/2022

MDM2 binds directly to p53, inhibiting its transcriptional activity. Additionally, MDM2 ubiquitinates p53, targeting it for proteasomal degradation, thus regulating p53 levels in the cell.

What is the significance of the MDM2-p53 feedback loop in cellular regulation? 11/19/2022

The MDM2-p53 feedback loop is crucial for cellular homeostasis. When DNA damage occurs, p53 levels rise, leading to cell cycle arrest or apoptosis. Elevated p53 can induce MDM2 expression, which in turn downregulates p53, ensuring that p53 activity is transient.

How do amplifications or overexpression of MDM2 contribute to cancer progression? 05/13/2022

Amplifications or overexpression of MDM2 can lead to reduced p53 activity, even in the presence of DNA damage or other stress signals, potentially contributing to uncontrolled cell proliferation and tumorigenesis.

Are there any known inhibitors targeting MDM2, and what are their therapeutic implications? 03/31/2022

Several small molecule inhibitors, like Nutlin-3 and RG7112, target MDM2 to prevent its interaction with p53, thereby stabilizing and activating p53. These inhibitors hold therapeutic potential, especially in tumors with wild-type p53 but overexpressed MDM2.

How does the interaction between MDM2 and other proteins influence cell cycle and apoptosis? 12/20/2021

Besides p53, MDM2 interacts with other proteins, including E2F1 and RB, influencing cell cycle progression and apoptosis. The balance of these interactions can determine cell fate.

What is the primary function of the MDM2 gene and its encoded protein? 02/18/2019

The MDM2 gene encodes a nuclear-localized E3 ubiquitin ligase. Its primary function is to regulate the p53 tumor suppressor protein's stability and activity.

What are the potential therapeutic strategies for targeting MDM2 in cancer treatment? 07/29/2018

Therapeutic strategies targeting MDM2 include the use of MDM2 inhibitors to reactivate p53, combination therapies with DNA-damaging agents, and strategies to disrupt MDM2's interaction with other proteins to modulate cell cycle and apoptosis.

Customer Reviews (3)

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    Validated in multiple assays.


      Great for cell culture.


        Consistent performance, highly reproducible.

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