Recombinant Mouse MDM2 Protein (1-489 aa), His-tagged
Cat.No. : | MDM2-651M |
Product Overview : | Recombinant Mouse MDM2 Protein (1-489 aa) is produced by E. coli expression system. This protein is fused with a 6xHis tag at the N-terminal. Protein Description: Full Length. |
- Specification
- Gene Information
- Related Products
Description : | E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes th to proteasomal degradation. |
Source : | E. coli |
Species : | Mouse |
Tag : | His |
Form : | Tris-based buffer, 50% glycerol |
Molecular Mass : | 58.6 kDa |
Protein length : | 1-489 aa |
AA Sequence : | MCNTNMSVSTEGAASTSQIPASEQE TLVRPKPLLLKLLKSVGAQNDTYTM KEIIFYIGQYIMTKRLYDEKQQHIV YCSNDLLGDVFGVPSFSVKEHRKIY AMIYRNLVAVSQQDSGTSLSESRRQ PEGGSDLKDPLQAPPEEKPSSSDLI SRLSTSSRRRSISETEENTDELPGE RHRKRRRSLSFDPSLGLCELREMCS GGSSSSSSSSSESTETPSHQDLDDG VSEHSGDCLDQDSVSDQFSVEFEVE SLDSEDYSLSDEGHELSDEDDEVYR VTVYQTGESDTDSFEGDPEISLADY WKCTSCNEMNPPLPSHCKRCWTLRE NWLPDDKGKDKVEISEKAKLENSAQ AEEGLDVPDGKKLTENDAKEPCAEE DSEEKAEQTPLSQESDDYSQPSTSS SIVYSSQESVKELKEETQDKDESVE SSFSLNAIEPCVICQGRPKNGCIVH GKTGHLMSCFTCAKKLKKRNKPCPV CRQPIQMIVLTYFN |
Purity : | > 90% as determined by SDS-PAGE. |
Notes : | Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week. |
Storage : | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade. |
Concentration : | A hardcopy of COA with concentration instruction is sent along with the products. |
Gene Name : | Mdm2 transformed mouse 3T3 cell double minute 2 [ Mus musculus ] |
Official Symbol : | MDM2 |
Synonyms : | MDM2; Mdm-2; AA415488; 1700007J15Rik; |
Gene ID : | 17246 |
mRNA Refseq : | NM_010786 |
Protein Refseq : | NP_034916 |
UniProt ID : | P23804 |
Products Types
◆ Recombinant Protein | ||
MDM2-2814H | Recombinant Human MDM2 protein(31-260 aa), C-His-tagged | +Inquiry |
MDM2-3449H | Recombinant Human MDM2 Protein, His (Fc)-Avi-tagged | +Inquiry |
Mdm2-1771M | Recombinant Mouse Mdm2 Protein, His-tagged | +Inquiry |
MDM2-0426H | Recombinant Human MDM2 Protein (S17-N111), Tag Free | +Inquiry |
MDM2-0427H | Recombinant Human MDM2 Protein (S17-N111), His tagged | +Inquiry |
◆ Lysates | ||
MDM2-4404HCL | Recombinant Human MDM2 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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