Recombinant Rhesus monkey MDM2 Protein, His-tagged

Cat.No. : MDM2-2711R
Product Overview : Recombinant Rhesus monkey MDM2 full length or partial length protein was expressed.
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Source : Mammalian Cells
Species : Rhesus monkey
Tag : His
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method.
Purity : >80%
Notes : This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
Storage : Store it at +4 ºC for short term. For long term storage, store it at -20 ºC~-80 ºC.
Storage Buffer : PBS buffer
Gene Name : MDM2 Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) [ Macaca mulatta (Rhesus monkey) ]
Official Symbol : MDM2
Synonyms : MDM2; E3 ubiquitin-protein ligase Mdm2; Mdm2 p53 binding protein homolog; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein;
Gene ID : 718284
mRNA Refseq : NM_001266402
Protein Refseq : NP_001253331
MIM :
UniProt ID : H9FUJ1

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does MDM2 regulate the tumor suppressor protein p53? 11/20/2022

MDM2 binds directly to p53, inhibiting its transcriptional activity. Additionally, MDM2 ubiquitinates p53, targeting it for proteasomal degradation, thus regulating p53 levels in the cell.

What is the significance of the MDM2-p53 feedback loop in cellular regulation? 11/19/2022

The MDM2-p53 feedback loop is crucial for cellular homeostasis. When DNA damage occurs, p53 levels rise, leading to cell cycle arrest or apoptosis. Elevated p53 can induce MDM2 expression, which in turn downregulates p53, ensuring that p53 activity is transient.

How do amplifications or overexpression of MDM2 contribute to cancer progression? 05/13/2022

Amplifications or overexpression of MDM2 can lead to reduced p53 activity, even in the presence of DNA damage or other stress signals, potentially contributing to uncontrolled cell proliferation and tumorigenesis.

Are there any known inhibitors targeting MDM2, and what are their therapeutic implications? 03/31/2022

Several small molecule inhibitors, like Nutlin-3 and RG7112, target MDM2 to prevent its interaction with p53, thereby stabilizing and activating p53. These inhibitors hold therapeutic potential, especially in tumors with wild-type p53 but overexpressed MDM2.

How does the interaction between MDM2 and other proteins influence cell cycle and apoptosis? 12/20/2021

Besides p53, MDM2 interacts with other proteins, including E2F1 and RB, influencing cell cycle progression and apoptosis. The balance of these interactions can determine cell fate.

What is the primary function of the MDM2 gene and its encoded protein? 02/18/2019

The MDM2 gene encodes a nuclear-localized E3 ubiquitin ligase. Its primary function is to regulate the p53 tumor suppressor protein's stability and activity.

What are the potential therapeutic strategies for targeting MDM2 in cancer treatment? 07/29/2018

Therapeutic strategies targeting MDM2 include the use of MDM2 inhibitors to reactivate p53, combination therapies with DNA-damaging agents, and strategies to disrupt MDM2's interaction with other proteins to modulate cell cycle and apoptosis.

Customer Reviews (3)

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Reviews
12/24/2021

    Validated in multiple assays.

    07/14/2019

      Great for cell culture.

      04/05/2019

        Consistent performance, highly reproducible.

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