Recombinant Human MDM2 protein(31-260 aa), C-His-tagged

Cat.No. : MDM2-2814H
Product Overview : Recombinant Human MDM2 protein(Q00987)(31-260 aa), fused with C-terminal His tag, was expressed in E. coli.
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Source : E. coli
Species : Human
Tag : C-His
Protein length : 31-260 aa
Form : 0.15 M Phosphate buffered saline
AASequence : KPLLLKLLKSVGAQKDTYTMKEVLF YLGQYIMTKRLYDEKQQHIVYCSND LLGDLFGVPSFSVKEHRKIYTMIYR NLVVVNQQESSDSGTSVSENRCHLE GGSDQKDLVQELQEEKPSSSHLVSR PSTSSRRRAISETEENSDELSGERQ RKRHKSDSISLSFDESLALCVIREI CCERSSSSESTGTPSNPDLDAGVSE HSGDWLDQDSVSDQFSVEFEVESLD SEDYS
Storage : Shipped on dry ice. Avoid repeated freeze-thaw cycles. Upon receipt, 2 days when stored at 2 to 8 °C after thawing.
Up to 12 months when aliquoted and stored at -20 to -80°C.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.
Gene Name : MDM2 Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) [ Homo sapiens ]
Official Symbol : MDM2
Synonyms : MDM2; Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse); Mdm2 p53 binding protein homolog (mouse) , Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) , mouse double minute 2, human homolog of; p53 binding protein; E3 ubiquitin-protein ligase Mdm2; HDM2; HDMX; MGC5370; oncoprotein Mdm2; MDM2 variant FB28; MDM2 variant FB30; double minute 2, human homolog of; p53-binding protein; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein; hdm2; ACTFS; MGC71221;
Gene ID : 4193
mRNA Refseq : NM_002392
Protein Refseq : NP_002383
MIM : 164785
UniProt ID : Q00987

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does MDM2 regulate the tumor suppressor protein p53? 11/20/2022

MDM2 binds directly to p53, inhibiting its transcriptional activity. Additionally, MDM2 ubiquitinates p53, targeting it for proteasomal degradation, thus regulating p53 levels in the cell.

What is the significance of the MDM2-p53 feedback loop in cellular regulation? 11/19/2022

The MDM2-p53 feedback loop is crucial for cellular homeostasis. When DNA damage occurs, p53 levels rise, leading to cell cycle arrest or apoptosis. Elevated p53 can induce MDM2 expression, which in turn downregulates p53, ensuring that p53 activity is transient.

How do amplifications or overexpression of MDM2 contribute to cancer progression? 05/13/2022

Amplifications or overexpression of MDM2 can lead to reduced p53 activity, even in the presence of DNA damage or other stress signals, potentially contributing to uncontrolled cell proliferation and tumorigenesis.

Are there any known inhibitors targeting MDM2, and what are their therapeutic implications? 03/31/2022

Several small molecule inhibitors, like Nutlin-3 and RG7112, target MDM2 to prevent its interaction with p53, thereby stabilizing and activating p53. These inhibitors hold therapeutic potential, especially in tumors with wild-type p53 but overexpressed MDM2.

How does the interaction between MDM2 and other proteins influence cell cycle and apoptosis? 12/20/2021

Besides p53, MDM2 interacts with other proteins, including E2F1 and RB, influencing cell cycle progression and apoptosis. The balance of these interactions can determine cell fate.

What is the primary function of the MDM2 gene and its encoded protein? 02/18/2019

The MDM2 gene encodes a nuclear-localized E3 ubiquitin ligase. Its primary function is to regulate the p53 tumor suppressor protein's stability and activity.

What are the potential therapeutic strategies for targeting MDM2 in cancer treatment? 07/29/2018

Therapeutic strategies targeting MDM2 include the use of MDM2 inhibitors to reactivate p53, combination therapies with DNA-damaging agents, and strategies to disrupt MDM2's interaction with other proteins to modulate cell cycle and apoptosis.

Customer Reviews (3)

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Reviews
12/24/2021

    Validated in multiple assays.

    07/14/2019

      Great for cell culture.

      04/05/2019

        Consistent performance, highly reproducible.

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