MPL

  • Official Full Name

    myeloproliferative leukemia virus oncogene

  • Overview

    In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.
  • Synonyms

    myeloproliferative leukemia virus oncogene; CD110; TPO-R; c-mpl; hlb219; c-mpl-I; c-mpl-II; MPLV; TPOR; THCYT2;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Cell & Tissue Lysates
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • C
  • His
  • Fc Chimera
  • GST
  • His (Fc)
  • Avi
  • His|T7
  • HlgG1 Fc
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MPL-7001H Recombinant Human MPL protein, His & T7-tagged E.coli His/T7 Ser311~Gln460 (Accession # P40238)
Human MPL-5504H Recombinant Human MPL Protein Wheat Germ N/A
Human MPL-102H Recombinant Human MPL Protein, C-His-tagged E.coli C-His
Human MPL-6324HF Recombinant Full Length Human MPL Protein In Vitro Cell Free System 407 amino acids
Human MPL-1460H Recombinant Human MPL Protein (26-491 aa), His-tagged Yeast His 26-491 aa
Human MPL-5505H Recombinant Human MPL Protein, GST-tagged Wheat Germ GST
Human MPL-1496H Recombinant Human MPL Protein (Ser311-Gln460), N-His tagged E.coli N-His Ser311-Gln460
Human MPL-1935H Active Recombinant Human MPL protein, His-tagged HEK293 His Gln 26 - Trp 491
Human MPL-4592H Recombinant Human MPL Protein (Met1-Trp491), C-His tagged Mammalian cells C-His Met1-Trp491
Human MPL-661H Recombinant Human MPL Protein (26-491 aa), His-tagged E.coli His 26-491 aa
Human MPL-6325HF Recombinant Full Length Human MPL Protein, GST-tagged In Vitro Cell Free System GST 635 amino acids
Mouse Mpl-496M Active Recombinant Mouse Mpl, Fc Chimera Mammalian cells Fc Chimera
Mouse Mpl-7002M Recombinant Mouse Mpl protein, His & T7-tagged E.coli His/T7 Leu66~Ser260 (Accession # Q08351)
Mouse Mpl-144M-B Recombinant Mouse Mpl Protein Pre-coupled Magnetic Beads HEK293
Mouse Mpl-144M Recombinant Mouse Mpl Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Mpl-35R Recombinant Rat Mpl, His tagged Insect Cell His
Rat MPL-001RCL Recombinant Rat MPL cell lysate Insect Cell N/A
Rat MPL-1132R Recombinant Rat MPL Protein (Met1-Ala500), HlgG1 Fc-tagged HEK293 HlgG1 Fc Met1-Ala500
Zebrafish MPL-1145Z Recombinant Zebrafish MPL Mammalian Cell His
Chicken MPL-1173C Recombinant Chicken MPL Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

MPL involved in several pathways and played different roles in them. We selected most pathways MPL participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MPL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionMET;LIFRA;TGFB1A;FLT1;TNF;ACVR2B;IL2RGA;TNFRSF9;LIFR
Jak-STAT signaling pathwaySTAT3;IL6;IFNB1;Il2;IL2RGA;IL13RA2;SOCS1;IFNA7;STAM2

MPL has several biochemical functions, for example, protein binding, thrombopoietin receptor activity, transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MPL itself. We selected most functions MPL had, and list some proteins which have the same functions with MPL. You can find most of the proteins on our site.

Function Related Protein
protein bindingLASP1;JUNB;UBE2O;IPO7;CUL4B;TSSK1;OCRL;OXA1L;KRTAP23-1
thrombopoietin receptor activity
transmembrane signaling receptor activityGIPR;RYK;OR4N4;FZD3A;CD72;TNFRSF10D;BAI2;IGSF6;IL27RA

MPL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MPL here. Most of them are supplied by our site. Hope this information will be useful for your research of MPL.

JAK2; ATXN2L

Research Area

Related articles

Bernstein, DI; Atmar, RL; et al. Norovirus Vaccine Against Experimental Human GII.4 Virus Illness: A Challenge Study in Healthy Adults. JOURNAL OF INFECTIOUS DISEASES 211:870-878(2015).
Leroux-Roels, G; Van Belle, P; et al. Vaccine Adjuvant Systems containing monophosphoryl lipid A and QS-21 induce strong humoral and cellular immune responses against hepatitis B surface antigen which persist for at least 4 years after vaccination. VACCINE 33:1084-1091(2015).
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