Recombinant Human MPL Protein (Met1-Trp491), C-His tagged

Cat.No. : MPL-4592H
Product Overview : Recombinant human MPL (Met1-Trp491) fused with the C-terminal His tag was expressed in Mammalian cells.
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Description : Thrombopoietin receptor (Tpo R), also known as myeloproliferative leukemia protein (c-mpl), is a 95 kDa type I transmembrane protein that is a member of the type I cytokine receptor family within the hematopoietin/cytokine receptor superfamily. The 635 amino acid (aa) full-length human Tpo R contains a 25 aa signal sequence, a 466 aa extracellular domain with a ligand binding domain and two fibronectin type III domains, a transmembrane (TM) domain and a cytoplasmic domain. The extracellular domain of human Tpo R shares 78%, 76%, 81%, 82% and 80% aa identity with mouse, rat, bovine, canine and equine Tpo R, respectively. Humans produce three distinct mRNA species; a P-form, a K-form, and a truncated form (Mpl-tr) lacking a TM domain. The P-form encodes the full-length receptor. The Mpl-tr form, which is expressed in both human and mouse, is intracellular and targets the P-form for degradation. The 579 aa K-form has an alternate cytoplasmic domain, but does not dimerize with, or inhibit, the P-form. Thrombopoietin (Tpo) is a key regulator of megakaryocytopoiesis, thrombopoiesis and hematopoietic stem cell self-renewal, as reflected by expression of the Tpo R on megakaryocytes, platelets and hematopoietic progenitors. Receptor dimerization occurs upon Tpo binding and initiates signaling through the Ras/MAP and JAK/STAT pathways. Internalization and degradation of Tpo following Tpo R binding serves to downregulate circulating Tpo. Tpo R expressed at low levels on endothelial cells does not appear to contribute to regulation of Tpo. Inactivating mutations of Tpo R cause thrombocytopenia, and absence of functional Tpo R is lethal in humans, but not mice. Other mutations, including an activating change in the TM domain, can cause thrombocytosis.
Source : Mammalian cells
Species : Human
Tag : His
Form : Lyophilized powder/frozen liquid
Molecular Mass : 54.01 kDa
Protein Length : Met1-Trp491
Endotoxin : < 1.0 EU/μg of the protein as determined by the LAL method.
Purity : >90% as determined by SDS-PAGE.
Notes : For research use only.
Storage : Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
Storage Buffer : Supplied as solution form in PBS or lyophilized from PBS.
Reconstitution : Reconstitute in sterile water for a stock solution.
Shipping : They are shipped out with dry ice/blue ice unless customers require otherwise.
Gene Name : MPL myeloproliferative leukemia virus oncogene [ Homo sapiens (human) ]
Official Symbol : MPL
Synonyms : MPL; myeloproliferative leukemia virus oncogene; thrombopoietin receptor; CD110; TPOR; TPO-R; proto-oncogene c-Mpl; myeloproliferative leukemia protein; MPLV; C-MPL; THCYT2;
Gene ID : 4352
mRNA Refseq : NM_005373
Protein Refseq : NP_005364
MIM : 159530
UniProt ID : P40238

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.


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